Q5EB81
Gene name |
Cyb5r1 |
Protein name |
NADH-cytochrome b5 reductase 1 |
Names |
b5R.1 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:304805 |
EC number |
1.6.2.2: With a heme protein as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5EB81
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5EB81-F1 | Predicted | AlphaFoldDB |
No variants for Q5EB81
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5EB81 | |||||
No associated diseases with Q5EB81
5 regional properties for Q5EB81
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 22 - 85 | IPR002048-1 |
| domain | EF-hand domain | 87 - 163 | IPR002048-2 |
| binding_site | EF-Hand 1, calcium-binding site | 63 - 75 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 100 - 112 | IPR018247-2 |
| binding_site | EF-Hand 1, calcium-binding site | 141 - 153 | IPR018247-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.6.2.2 | With a heme protein as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytochrome-b5 reductase activity, acting on NAD(P)H | Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5). |
| FAD binding | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHW9 | CYB5R1 | NADH-cytochrome b5 reductase 1 | Bos taurus (Bovine) | PR |
| Q96HP4 | OXNAD1 | Oxidoreductase NAD-binding domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q9UHQ9 | CYB5R1 | NADH-cytochrome b5 reductase 1 | Homo sapiens (Human) | PR |
| Q9DB73 | Cyb5r1 | NADH-cytochrome b5 reductase 1 | Mus musculus (Mouse) | PR |
| Q9ZNT1 | CBR1 | NADH--cytochrome b5 reductase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGIQPSPVLL | ASLGVGLFTL | FGLALGTYLV | RRSRRPQVTL | QDPDEKYLLR | LLDKTTVSHN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TRRFRFALPT | AHHILGLPVG | KHVYLSARID | GSQVIRPYTP | VTSDEDQGYV | DLVIKVYLKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VHPKFSEGGK | MSQYLDSLKI | GDVVEFRGPS | GLLSYAGKGN | FNIQPNKKSP | PELRVAKKLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MIAGGTGITP | MLQLIRAILK | VPEDPTQCFL | LFANQTEKDI | ILREDLEELQ | AQYPIRFKLW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FTLDYPPEDW | TYSKGFVTAD | MIQEHLPAPA | EDVLLLLCGP | PPMVQLACHP | NLDKLGYSQK |
| MRFTY |