Q9DB73

PR
Gene name
Cyb5r1 (Nqo3a2)
Protein name
NADH-cytochrome b5 reductase 1
Names
b5R.1, NAD(P)H:quinone oxidoreductase type 3 polypeptide A2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72017
EC number
1.6.2.2: With a heme protein as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9DB73

Entry ID Method Resolution Chain Position Source
AF-Q9DB73-F1 Predicted AlphaFoldDB

11 variants for Q9DB73

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3390612517 29 L>M No EVA
rs3388497338 32 R>* No EVA
rs3388502213 61 T>S No EVA
rs3388497325 122 H>L No EVA
rs13474519 143 M>V No EVA
rs30875255 147 R>W No EVA
rs3388501840 151 G>R No EVA
rs3388498707 199 L>F No EVA
rs3390675097 215 Q>L No EVA
rs30872491 245 S>Y No EVA
rs3388502161 297 Y>H No EVA

No associated diseases with Q9DB73

10 regional properties for Q9DB73

Type Name Position InterPro Accession
domain UVR domain 511 - 546 IPR001943
domain AAA+ ATPase domain 294 - 434 IPR003593-1
domain AAA+ ATPase domain 638 - 785 IPR003593-2
domain ATPase, AAA-type, core 299 - 415 IPR003959-1
domain ATPase, AAA-type, core 637 - 811 IPR003959-2
domain Clp, repeat (R) domain 94 - 236 IPR004176
conserved_site ClpA/B, conserved site 1 389 - 401 IPR018368
domain Clp ATPase, C-terminal 818 - 908 IPR019489
conserved_site ClpA/B, conserved site 2 672 - 690 IPR028299
domain ClpA/ClpB, AAA lid domain 437 - 538 IPR041546

Functions

Description
EC Number 1.6.2.2 With a heme protein as acceptor
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
cytochrome-b5 reductase activity, acting on NAD(P)H Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

1 GO annotations of biological process

Name Definition
sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHW9 CYB5R1 NADH-cytochrome b5 reductase 1 Bos taurus (Bovine) PR
Q96HP4 OXNAD1 Oxidoreductase NAD-binding domain-containing protein 1 Homo sapiens (Human) PR
Q9UHQ9 CYB5R1 NADH-cytochrome b5 reductase 1 Homo sapiens (Human) PR
Q5EB81 Cyb5r1 NADH-cytochrome b5 reductase 1 Rattus norvegicus (Rat) PR
Q9ZNT1 CBR1 NADH--cytochrome b5 reductase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGIQPSPVLL ASLGVGLLTL LGLALGTYLV RRSRRPQVTL QDPDEKYLLR LLDKTTVSHN
70 80 90 100 110 120
TRRFRFALPT AHHILGLPVG KHVYLSARID GSLVIRPYTP VTSDEDQGYV DLVIKVYLKG
130 140 150 160 170 180
VHPKFPEGGK MSQYLDSLKI GDMVEFRGPS GLLSYAGKGN FNIQPNKKSP PELRVAKKLG
190 200 210 220 230 240
MIAGGTGITP MLQLIRAILK VPEDPTQCFL LFANQTERDI ILREDLEELQ AQYPNRFKLW
250 260 270 280 290 300
FTLDSPPEDW TYSKGFVTAD MIQEHLPAPA EDVLLLLCGP PPMVQLACHP NLDKLGYSQK
MRFTY