Q3MHW9
Gene name |
CYB5R1 |
Protein name |
NADH-cytochrome b5 reductase 1 |
Names |
b5R.1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:516287 |
EC number |
1.6.2.2: With a heme protein as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3MHW9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3MHW9-F1 | Predicted | AlphaFoldDB |
105 variants for Q3MHW9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs458119861 | 6 | S>G | No | EVA | |
| rs478108188 | 7 | P>R | No | EVA | |
| rs450023221 | 8 | V>G | No | EVA | |
| rs480621233 | 16 | G>E | No | EVA | |
| rs470184460 | 16 | G>R | No | EVA | |
| rs449502829 | 17 | L>M | No | EVA | |
| rs466442937 | 18 | L>V | No | EVA | |
| rs445454760 | 22 | G>S | No | EVA | |
| rs436876684 | 27 | A>T | No | EVA | |
| rs456989435 | 27 | A>V | No | EVA | |
| rs137388115 | 28 | Y>S | No | EVA | |
| rs435943903 | 29 | L>R | No | EVA | |
| rs453140494 | 30 | V>A | No | EVA | |
| rs473320465 | 32 | R>G | No | EVA | |
| rs438609033 | 33 | S>A | No | EVA | |
| rs438609033 | 33 | S>P | No | EVA | |
| rs443712616 | 34 | R>L | No | EVA | |
| rs475372089 | 34 | R>S | No | EVA | |
| rs449256425 | 36 | P>S | No | EVA | |
| rs480086973 | 41 | L>M | No | EVA | |
| rs445491801 | 42 | D>A | No | EVA | |
| rs465581890 | 44 | N>T | No | EVA | |
| rs450505547 | 45 | E>G | No | EVA | |
| rs437367677 | 45 | E>Q | No | EVA | |
| rs450505547 | 45 | E>V | No | EVA | |
| rs436028403 | 47 | Y>* | No | EVA | |
| rs467452382 | 47 | Y>S | No | EVA | |
| rs452870564 | 48 | Q>H | No | EVA | |
| rs432236728 | 49 | L>Q | No | EVA | |
| rs473137033 | 49 | L>V | No | EVA | |
| rs452262877 | 51 | L>P | No | EVA | |
| rs452262877 | 51 | L>R | No | EVA | |
| rs444179243 | 53 | D>A | No | EVA | |
| rs463857635 | 54 | K>Q | No | EVA | |
| rs461560767 | 56 | T>A | No | EVA | |
| rs461560767 | 56 | T>S | No | EVA | |
| rs481675656 | 62 | K>R | No | EVA | |
| rs476882102 | 72 | H>D | No | EVA | |
| rs462397510 | 75 | L>M | No | EVA | |
| rs450060419 | 81 | K>N | No | EVA | |
| rs480935525 | 86 | S>A | No | EVA | |
| rs449566981 | 87 | A>T | No | EVA | |
| rs434927340 | 94 | V>A | No | EVA | |
| rs465056995 | 96 | R>S | No | EVA | |
| rs436824544 | 98 | Y>C | No | EVA | |
| rs456899474 | 99 | T>A | No | EVA | |
| rs467679655 | 99 | T>I | No | EVA | |
| rs436267779 | 103 | S>I | No | EVA | |
| rs453062369 | 105 | E>G | No | EVA | |
| rs471611047 | 163 | I>S | No | EVA | |
| rs463039848 | 175 | V>M | No | EVA | |
| rs448457840 | 181 | M>R | No | EVA | |
| rs462000532 | 183 | A>G | No | EVA | |
| rs474479590 | 189 | T>I | No | EVA | |
| rs459955314 | 190 | P>S | No | EVA | |
| rs481531130 | 217 | E>D | No | EVA | |
| rs446913451 | 218 | K>T | No | EVA | |
| rs466935343 | 222 | L>* | No | EVA | |
| rs432318209 | 231 | A>V | No | EVA | |
| rs452767880 | 233 | H>P | No | EVA | |
| rs469508808 | 233 | H>Q | No | EVA | |
| rs452767880 | 233 | H>R | No | EVA | |
| rs438190709 | 239 | L>R | No | EVA | |
| rs454987618 | 241 | F>V | No | EVA | |
| rs474979332 | 242 | T>P | No | EVA | |
| rs470611142 | 245 | H>R | No | EVA | |
| rs462881024 | 246 | P>H | No | EVA | |
| rs439184212 | 246 | P>T | No | EVA | |
| rs442029028 | 250 | W>S | No | EVA | |
| rs462158260 | 251 | A>G | No | EVA | |
| rs479020792 | 252 | Y>D | No | EVA | |
| rs441518690 | 253 | S>I | No | EVA | |
| rs458360027 | 254 | K>N | No | EVA | |
| rs478428781 | 256 | F>V | No | EVA | |
| rs450308102 | 257 | V>G | No | EVA | |
| rs463488450 | 264 | E>D | No | EVA | |
| rs480318138 | 266 | L>Q | No | EVA | |
| rs435772448 | 268 | A>T | No | EVA | |
| rs448857715 | 273 | V>A | No | EVA | |
| rs434365657 | 274 | L>P | No | EVA | |
| rs456983584 | 281 | P>H | No | EVA | |
| rs435673586 | 283 | M>I | No | EVA | |
| rs472667148 | 284 | V>G | No | EVA | |
| rs455719544 | 284 | V>L | No | EVA | |
| rs441166803 | 285 | Q>P | No | EVA | |
| rs458495519 | 286 | L>P | No | EVA | |
| rs458495519 | 286 | L>R | No | EVA | |
| rs472076482 | 287 | A>P | No | EVA | |
| rs443900017 | 288 | C>G | No | EVA | |
| rs480784261 | 289 | H>R | No | EVA | |
| rs463978550 | 289 | H>Y | No | EVA | |
| rs449007021 | 290 | P>R | No | EVA | |
| rs459359258 | 292 | L>M | No | EVA | |
| rs479508815 | 292 | L>R | No | EVA | |
| rs459359258 | 292 | L>V | No | EVA | |
| rs444785371 | 294 | K>I | No | EVA | |
| rs464755665 | 295 | L>M | No | EVA | |
| rs437061815 | 295 | L>R | No | EVA | |
| rs450670798 | 297 | Y>C | No | EVA | |
| rs467417234 | 298 | S>* | No | EVA | |
| rs455845240 | 300 | K>T | No | EVA | |
| rs472674783 | 301 | M>L | No | EVA | |
| rs434816002 | 302 | R>G | No | EVA | |
| rs451730848 | 302 | R>L | No | EVA | |
| rs471742452 | 305 | Y>D | No | EVA |
No associated diseases with Q3MHW9
Functions
| Description | ||
|---|---|---|
| EC Number | 1.6.2.2 | With a heme protein as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytochrome-b5 reductase activity, acting on NAD(P)H | Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5). |
| FAD binding | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96HP4 | OXNAD1 | Oxidoreductase NAD-binding domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q9UHQ9 | CYB5R1 | NADH-cytochrome b5 reductase 1 | Homo sapiens (Human) | PR |
| Q9DB73 | Cyb5r1 | NADH-cytochrome b5 reductase 1 | Mus musculus (Mouse) | PR |
| Q5EB81 | Cyb5r1 | NADH-cytochrome b5 reductase 1 | Rattus norvegicus (Rat) | PR |
| Q9ZNT1 | CBR1 | NADH--cytochrome b5 reductase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLQPSPVLL | ASLGVGLLTL | LGVALGAYLV | RRSRRPPVTL | LDPNEKYQLR | LLDKTTVNHN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TKRFRFALPT | AHHVLGLPVG | KHVYLSARID | GSLVIRPYTP | VTSDEDQGYV | DLVIKVYLKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VHPKFPEGGK | MSQYLDSLKI | GDVVEFRGPS | GLLTYAGKGK | FNIQPNKKAP | PEARVARNLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MIAGGTGITP | MLQLIRAILK | DPEDPTQCFL | LFANQTEKDI | ILREDLEELQ | ARHPGRFKLW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FTLDHPPEGW | AYSKGFVSVD | MIREHLPAPG | EDVLLLLCGP | PPMVQLACHP | SLDKLGYSPK |
| MRFTY |