AiPD: Autoinhibited Protein Database

Gene name	Oasl2
Protein name	2'-5'-oligoadenylate synthase-like protein 2
Names	54 kDa 2'-5'-oligoadenylate synthase-like protein, p54 OASL, M1204
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:23962
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-54 (Predicted disordered autoinhibitory region) PR

1-54 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Z2F2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388789562	52	E>K	No	EVA
rs3396196387	73	G>V	No	EVA
rs32140123	75	T>M	No	EVA
rs3388784292	81	D>V	No	EVA
rs32141034	95	E>K	No	EVA
rs13463536	102	E>D	No	EVA
rs3388774781	120	A>D	No	EVA
rs32141035	124	I>F	No	EVA
rs3388772133	128	H>Q	No	EVA
rs3395682302	130	E>G	No	EVA
rs29822904	134	A>P	No	EVA
rs29822904	134	A>T	No	EVA
rs3388789618	177	E>D	No	EVA
rs32141038	185	Y>H	No	EVA
rs3388772104	206	V>I	No	EVA
rs3388789605	221	Q>L	No	EVA
rs3388789572	241	L>M	No	EVA
rs3388753746	256	S>N	No	EVA
rs3388753725	257	F>I	No	EVA
rs3388777495	273	Y>F	No	EVA
rs32142001	274	R>H	No	EVA
rs3388753724	282	K>N	No	EVA
rs3388786221	288	N>Y	No	EVA
rs246493875	320	K>N	No	EVA
rs3388776392	330	A>D	No	EVA
rs3388783931	335	Q>*	No	EVA
rs32142969	339	T>R	No	EVA
rs229463169	345	E>K	No	EVA
rs3396091067	351	R>G	No	EVA
rs245249232	351	R>P	No	EVA
rs265278756	352	A>S	No	EVA
rs3396029785	353	R>K	No	EVA
rs255682007	431	F>I	No	EVA
rs3388776328	433	P>H	No	EVA
rs32145416	450	T>A	No	EVA
rs3388764463	456	T>I	No	EVA
rs3388783375	469	G>D	No	EVA
rs218463708	472	A>V	No	EVA
rs252740003	476	V>I	No	EVA
rs3388774829	479	L>*	No	EVA
rs32145417	491	K>E	No	EVA
rs13463538	508	D>H	No	EVA

Type	Name	Position	InterPro Accession
domain	Ubiquitin-like domain	435 - 506	IPR000626
domain	2-5OAS/ClassI-CCAase, nucleotidyltransferase domain	29 - 214	IPR006116
conserved_site	2-5-oligoadenylate synthetase, C-terminal conserved site	303 - 313	IPR006117
domain	2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal	170 - 351	IPR018952
conserved_site	2-5-oligoadenylate synthetase, N-terminal conserved site	68 - 87	IPR043518

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
2'-5'-oligoadenylate synthetase activity	Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
double-stranded RNA binding	Binding to double-stranded RNA.
metal ion binding	Binding to a metal ion.

Name	Definition
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
interleukin-27-mediated signaling pathway	The series of molecular signals initiated by interleukin-27 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
negative regulation of viral genome replication	Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
purine nucleotide biosynthetic process	The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
regulation of ribonuclease activity	Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
response to virus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2T9Q2	UBL4B	Ubiquitin-like protein 4B	Bos taurus (Bovine)	PR
P11441	UBL4A	Ubiquitin-like protein 4A	Homo sapiens (Human)	PR
Q9CQ84	Ubl4b	Ubiquitin-like protein 4B	Mus musculus (Mouse)	PR
P11928	Oas1a	2'-5'-oligoadenylate synthase 1A	Mus musculus (Mouse)	PR
Q5MYT9	Oasl2	2'-5'-oligoadenylate synthase-like protein 2	Rattus norvegicus (Rat)	PR