Q5MYT9

PR
Gene name
Oasl2
Protein name
2'-5'-oligoadenylate synthase-like protein 2
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:304549
EC number
2.7.7.84: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

96-169 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5MYT9

Entry ID Method Resolution Chain Position Source
AF-Q5MYT9-F1 Predicted AlphaFoldDB

No variants for Q5MYT9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5MYT9

No associated diseases with Q5MYT9

6 regional properties for Q5MYT9

Type Name Position InterPro Accession
domain Ubiquitin-like domain 359 - 434 IPR000626-1
domain Ubiquitin-like domain 439 - 510 IPR000626-2
domain 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain 29 - 214 IPR006116
conserved_site 2-5-oligoadenylate synthetase, C-terminal conserved site 302 - 312 IPR006117
domain 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal 170 - 345 IPR018952
conserved_site 2-5-oligoadenylate synthetase, N-terminal conserved site 68 - 87 IPR043518

Functions

Description
EC Number 2.7.7.84 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name Definition
2'-5'-oligoadenylate synthetase activity Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
double-stranded RNA binding Binding to double-stranded RNA.
metal ion binding Binding to a metal ion.

5 GO annotations of biological process

Name Definition
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of viral genome replication Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
regulation of ribonuclease activity Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
response to virus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2T9Q2 UBL4B Ubiquitin-like protein 4B Bos taurus (Bovine) PR
P11441 UBL4A Ubiquitin-like protein 4A Homo sapiens (Human) PR
P11928 Oas1a 2'-5'-oligoadenylate synthase 1A Mus musculus (Mouse) PR
Q9CQ84 Ubl4b Ubiquitin-like protein 4B Mus musculus (Mouse) PR
Q9Z2F2 Oasl2 2'-5'-oligoadenylate synthase-like protein 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MDTLPDLYGT VGDSLDYFLE HSLQPQRDWK EEGKDAWERI ERFFREKCFC DELLLDQEVR
70 80 90 100 110 120
VLKVVKGGSS GKGTALNHRS DQDMILFLSC FSSFKQQARD RKAVIDFIKS KLIHCRKSLA
130 140 150 160 170 180
YNITVRQHKE GKRTPRSLTL EIQSRKSNDI ICMDILPAYN ALGSFSRDCK PEPEIYENLI
190 200 210 220 230 240
RCKGYPGDFS PSFAELQRHF VKSRPVKLKN LLRLVKFWHL KYLRHKYRRA VLPSKYALEL
250 260 270 280 290 300
LTIYAWEMGT DSSDNFNLDE GFVAVMELLR DYQDICIYWT KYYDFQNEVV RNFLKEQLKG
310 320 330 340 350 360
DRPIILDPAD PTNNLGRRGK WELVAKEATY CLLQLCCVTA DRWNVQVSIA HYLRGARDVQ
370 380 390 400 410 420
VTVKQTGREE WILLTNPHSP IRKLKAKIKK RMNLCGELRI SFQEPGGERQ PLSGRKTLSD
430 440 450 460 470 480
YGIFSKVNIR VMETFPPEIQ VFVRYPGGQN KPFAIDPDAT ILSLWEKIEE DGGPCTEDWV
490 500 510
LLFEGEELDD DDNLAELQIK DCDTIQLSRV S