AiPD: Autoinhibited Protein Database

P11441

Gene name	UBL4A
Protein name	Ubiquitin-like protein 4A
Names	Ubiquitin-like protein GDX
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8266
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

46-139 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

46-139 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for P11441

Entry ID	Method	Resolution	Chain	Position	Source
2DZI	NMR	-	A	1-74	PDB
4WWR	X-ray	200 A	B/D/F/H	93-139	PDB
4X86	X-ray	185 A	A	95-147	PDB
7RU9	EM	330 A	E/H	1-157	PDB
7RUA	EM	340 A	E/H	1-157	PDB
7RUC	EM	360 A	H	1-157	PDB
AF-P11441-F1	Predicted				AlphaFoldDB

84 variants for P11441

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1557212992 CA415202099	4	T>M		No	ClinGen gnomAD
CA415202017 rs1557212987	8	L>P		No	ClinGen gnomAD
rs1557212984 CA415201940	12	E>*		No	ClinGen Ensembl
CA415201860 rs1382005748	14	S>R		No	ClinGen TOPMed gnomAD
rs1557212921 CA415201743	17	V>L		No	ClinGen gnomAD
CA415201701 rs1557212915	19	E>K		No	ClinGen TOPMed
CA10565465 rs782165041	24	S>Y		No	ClinGen ExAC gnomAD
rs1557212912 CA415201456	28	Q>H		No	ClinGen gnomAD
rs1238393189 CA415201434	29	L>Q		No	ClinGen TOPMed
CA10565464 rs782024019	33	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1557212911 CA415201376	33	K>R		No	ClinGen gnomAD
CA10565462 rs782254388	39	R>C		No	ClinGen ExAC gnomAD
rs1557212901 CA415201173	40	Q>H		No	ClinGen gnomAD
TCGA novel	45	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1603397391 CA415201090	45	F>V		No	ClinGen Ensembl
rs370563061 CA337293683	53	G>E		No	ClinGen ESP TOPMed gnomAD
rs1401707201 CA415200740	56	L>F		No	ClinGen TOPMed
rs782531758 CA10565428 COSM1118072	57	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1354344061 CA415200611	61	I>V		No	ClinGen TOPMed
CA10565426 rs782758096	62	G>E		No	ClinGen ExAC gnomAD
CA415200586 rs1412366328	62	G>R		No	ClinGen TOPMed
rs1557212765 CA415200476	65	S>Y		No	ClinGen gnomAD
CA415200453 rs1285641732	66	K>R		No	ClinGen TOPMed gnomAD
rs1285641732 CA415200455	66	K>T		No	ClinGen TOPMed gnomAD
rs1356573812 CA415200357	70	V>L		No	ClinGen TOPMed
rs782495618 CA10565425	71	V>I		No	ClinGen ExAC gnomAD
rs913973365 CA337293629	73	P>S		No	ClinGen Ensembl
rs374503557 CA10565420	82	G>D		No	ClinGen ESP ExAC gnomAD
CA415200186 rs1603397299	82	G>S		No	ClinGen Ensembl
CA415200176 rs782359606	83	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10565417 rs782359606	83	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs782215116 CA10565416	85	Q>*		No	ClinGen ExAC gnomAD
CA415200156 rs1557212746	85	Q>R		No	ClinGen gnomAD
TCGA novel	86	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781921631 CA10565415	88	A>P		No	ClinGen ExAC TOPMed gnomAD
rs781921631 CA337293546	88	A>T		No	ClinGen ExAC TOPMed gnomAD
rs782643777 CA10565412	89	D>A		No	ClinGen ExAC gnomAD
CA10565413 rs782283486 COSM1118070	89	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs782517386 CA10565411	90	S>P		No	ClinGen ExAC gnomAD
rs782230135 CA10565410	91	P>L		No	ClinGen ExAC gnomAD
CA10565407 rs781782880	93	P>A		No	ClinGen ExAC TOPMed gnomAD
rs782174250 CA10565406	93	P>L		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	93	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10565408 rs781782880	93	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1557212734 CA415200085	94	Q>R		No	ClinGen gnomAD
CA415200051 rs1557212726	98	L>V		No	ClinGen gnomAD
CA415200020 rs1557212718	101	K>E		No	ClinGen gnomAD
CA415200022 rs1557212718	101	K>Q		No	ClinGen gnomAD
rs781866836 CA10565404	102	V>I		No	ClinGen ExAC gnomAD
rs377663564 CA10565402	104	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs377663564 CA10565403	104	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs150392222 CA10565401	105	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs782405603 CA10565399	108	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782395991 CA10565397 COSM1118068	109	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1374745394 CA415199887	110	A>V		No	ClinGen TOPMed
rs1557212699 CA415199876	111	D>H		No	ClinGen gnomAD
COSM1118067 rs1557212699 CA415199874	111	D>Y	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs782247131 CA337293490	112	A>V		No	ClinGen 1000Genomes
rs1557212697 CA415199841	113	S>G		No	ClinGen gnomAD
rs1569554977 CA415199598	122	D>V		No	ClinGen Ensembl
rs781895687 CA415199568	124	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs781895687 CA10565359	124	E>Q		No	ClinGen ExAC gnomAD
rs372299383 CA337293253	126	S>Y		No	ClinGen ESP gnomAD
CA415199487 rs1557212620	129	R>C		No	ClinGen gnomAD
CA10565357 rs782123473	129	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	130	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781978076 CA10565356	131	T>M		No	ClinGen ExAC gnomAD
CA10565354 rs782387958	132	L>M		No	ClinGen ExAC TOPMed gnomAD
rs782305376 CA10565351	134	D>N		No	ClinGen ExAC gnomAD
CA415199401 rs1394297342	136	E>*		No	ClinGen TOPMed
rs1385439085 CA415199377	137	R>L		No	ClinGen TOPMed gnomAD
rs1385439085 CA415199379	137	R>Q		No	ClinGen TOPMed gnomAD
CA10565349 rs141549549	141	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA337293201 rs202239760	143	L>V		No	ClinGen 1000Genomes
rs782371138 CA10565348	145	P>L		No	ClinGen ExAC
rs976111106 CA337293192	148	T>I		No	ClinGen Ensembl
CA415199147 rs1276330802	151	M>T		No	ClinGen TOPMed
rs782604846 CA10565346	151	M>V		No	ClinGen ExAC gnomAD
rs782191064 CA415199097	154	G>C		No	ClinGen ExAC gnomAD
rs782191064 CA10565344	154	G>S		No	ClinGen ExAC gnomAD
CA10565343 rs782682012	156	S>F		No	ClinGen ExAC gnomAD
rs782819598 CA415199025	157	K>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs782819598 CA337293188	157	K>T		No	ClinGen 1000Genomes TOPMed gnomAD
TCGA novel	158	K>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P11441

7 regional properties for P11441

Type	Name	Position	InterPro Accession
domain	Ubiquitin-like domain	1 - 73	IPR000626
conserved_site	Ubiquitin conserved site	27 - 52	IPR019954
domain	Ubiquitin domain	11 - 31	IPR019956-1
domain	Ubiquitin domain	32 - 52	IPR019956-2
domain	Ubiquitin domain	53 - 74	IPR019956-3
domain	Ubl4, C-terminal TUGS domain	96 - 142	IPR041421
domain	UBL4A-like, ubiquitin-like domain	1 - 72	IPR044724

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
BAT3 complex	A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
ubiquitin-like protein transferase activity	Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.

5 GO annotations of biological process

Name	Definition
post-translational protein targeting to endoplasmic reticulum membrane	The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
protein modification process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
regulation of protein stability	Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
tail-anchored membrane protein insertion into ER membrane	A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2T9Q2	UBL4B	Ubiquitin-like protein 4B	Bos taurus (Bovine)	PR
Q9Z2F2	Oasl2	2'-5'-oligoadenylate synthase-like protein 2	Mus musculus (Mouse)	PR
P11928	Oas1a	2'-5'-oligoadenylate synthase 1A	Mus musculus (Mouse)	PR
Q9CQ84	Ubl4b	Ubiquitin-like protein 4B	Mus musculus (Mouse)	PR
Q5MYT9	Oasl2	2'-5'-oligoadenylate synthase-like protein 2	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MQLTVKALQG	RECSLQVPED	ELVSTLKQLV	SEKLNVPVRQ	QRLLFKGKAL	ADGKRLSDYS
70	80	90	100	110	120
IGPNSKLNLV	VKPLEKVLLE	EGEAQRLADS	PPPQVWQLIS	KVLARHFSAA	DASRVLEQLQ
130	140	150
RDYERSLSRL	TLDDIERLAS	RFLHPEVTET	MEKGFSK