AiPD: Autoinhibited Protein Database

Q9Y5K5

Gene name	UCHL5 (UCH37, AD-019, CGI-70)
Protein name	Ubiquitin carboxyl-terminal hydrolase isozyme L5
Names	UCH-L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51377
EC number	3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

212-329 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

212-329 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

11 structures for Q9Y5K5

Entry ID	Method	Resolution	Chain	Position	Source
3A7S	X-ray	220 A	A	1-228	PDB
3IHR	X-ray	295 A	A	1-329	PDB
3RII	X-ray	200 A	A/B	1-228	PDB
3RIS	X-ray	240 A	A/B/C/D	1-240	PDB
3TB3	X-ray	230 A	A/B	1-227	PDB
4UEL	X-ray	230 A	A	1-329	PDB
4UEM	X-ray	282 A	A	1-329	PDB
4UF5	X-ray	370 A	A	1-329	PDB
4UF6	X-ray	369 A	A/D/G/J	1-329	PDB
4WLP	X-ray	310 A	A	5-322	PDB
AF-Q9Y5K5-F1	Predicted				AlphaFoldDB

210 variants for Q9Y5K5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1421640856 CA344076372	2	T>M		No	ClinGen TOPMed
rs144390300 CA1302320	4	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1572022946 CA344076336	8	W>G		No	ClinGen Ensembl
rs1474300215 CA344076312	11	M>R		No	ClinGen gnomAD
CA1302318 rs751924395	13	S>G		No	ClinGen ExAC gnomAD
TCGA novel	16	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1558210404 CA344076252	19	T>I		No	ClinGen Ensembl
rs1188660418 CA344076220	24	G>*		No	ClinGen gnomAD
CA344076222 rs1188660418	24	G>R		No	ClinGen gnomAD
rs1476325898 CA344076218	24	G>V		No	ClinGen gnomAD
CA344076050 rs1215076306	28	R>*		No	ClinGen TOPMed gnomAD
rs770894191 CA1302309 COSM901362	28	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA344076039 rs1259842003	30	A>T		No	ClinGen gnomAD
CA1302308 rs760569217	30	A>V		No	ClinGen ExAC gnomAD
TCGA novel	34	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA35095658 rs201468959	35	I>M		No	ClinGen Ensembl
rs771715311 CA1302306	36	W>*		No	ClinGen ExAC gnomAD
CA1302307 rs773036600	36	W>R		No	ClinGen ExAC gnomAD
rs965461972 CA35095657	37	S>N		No	ClinGen TOPMed gnomAD
CA344075988 rs1370967170	37	S>R		No	ClinGen gnomAD
rs867696559 CA344075970	40	P>A		No	ClinGen TOPMed
rs867696559 CA35095656	40	P>T		No	ClinGen TOPMed
CA344075966 rs1443286529	41	E>K		No	ClinGen gnomAD
rs780193187 CA1302304	45	K>E		No	ClinGen ExAC gnomAD
CA1302303 rs770059388	46	L>S		No	ClinGen ExAC gnomAD
TCGA novel	47	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1379254977 CA344075897	48	P>S		No	ClinGen TOPMed
rs746140815 CA1302281	50	H>L		No	ClinGen ExAC gnomAD
rs746140815 CA1302280	50	H>R		No	ClinGen ExAC gnomAD
CA35095479 rs949826349	50	H>Y		No	ClinGen Ensembl
TCGA novel	51	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344075854 rs1193339729	55	L>I		No	ClinGen gnomAD
TCGA novel	55	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866279561 CA35095478	56	F>L		No	ClinGen Ensembl
rs1558156791 CA344075789	63	E>D		No	ClinGen Ensembl
rs1420609149 CA344075787	64	P>S		No	ClinGen TOPMed
rs1420609149 CA344075786	64	P>T		No	ClinGen TOPMed
rs747120010 CA1302276	67	S>C		No	ClinGen ExAC gnomAD
rs747120010 CA344075767	67	S>F		No	ClinGen ExAC gnomAD
CA1302277 rs770879529	67	S>P		No	ClinGen ExAC gnomAD
CA344075755 rs1571890173	69	V>G		No	ClinGen Ensembl
CA344075749 rs1365594464	70	Q>L		No	ClinGen TOPMed
COSM1337363 CA35095475 rs930538472	73	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
COSM1337362 CA35095474 rs920511079	73	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1270108114 CA344075727	74	L>F		No	ClinGen gnomAD
rs1342449791 CA344075721 COSM1337361	75	D>G	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA1302275 rs778080751 COSM73192	75	D>H	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs759028109 CA1302274	76	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1335960005 CA344075705	77	I>M		No	ClinGen gnomAD
rs1376245770 CA344075710	77	I>V		No	ClinGen gnomAD
CA1302271 rs140990934	78	F>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA35095473 rs79965312	79	F>L		No	ClinGen Ensembl
TCGA novel	85	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344075616 rs1232666387	88	C>Y		No	ClinGen gnomAD
rs748711153 CA1302253	90	T>A		No	ClinGen ExAC gnomAD
CA1302251 rs78945752	91	Q>K		No	ClinGen ExAC gnomAD
CA344075589 rs1558051571	92	A>G		No	ClinGen Ensembl
CA1302250 rs749668609	94	V>M		No	ClinGen ExAC gnomAD
rs1558051278 CA344075523	102	H>L		No	ClinGen Ensembl
CA344075518 rs1571600194	103	Q>E		No	ClinGen Ensembl
rs767106872 CA1302246	103	Q>H		No	ClinGen ExAC gnomAD
CA35093359 rs904558279	103	Q>R		No	ClinGen TOPMed gnomAD
CA344075509 rs1368765689	104	D>G		No	ClinGen TOPMed gnomAD
rs1448658923 CA344075511	104	D>H		No	ClinGen gnomAD
CA344075505 rs1325106270	105	V>I		No	ClinGen gnomAD
rs756784986 CA1302245	106	H>R		No	ClinGen ExAC TOPMed gnomAD
CA1302243 rs375196985	109	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	109	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370635844 CA1302242	110	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1159675234 CA344075452	113	E>*		No	ClinGen gnomAD
CA1302241 rs775409012	113	E>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	113	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344075436 rs1304349083	115	K>R		No	ClinGen TOPMed
rs1404672046 CA344075406	119	Q>R		No	ClinGen TOPMed
TCGA novel	120	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344075374 rs1193542022	123	A>V		No	ClinGen gnomAD
CA344075371 rs1571598991	124	A>T		No	ClinGen Ensembl
rs1297036136 CA344075366	124	A>V		No	ClinGen TOPMed
CA1302228 rs745477602	125	M>V		No	ClinGen ExAC TOPMed
CA344075324 rs1286632171	129	A>T		No	ClinGen gnomAD
TCGA novel	132	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1421965148 CA344075280	135	V>E		No	ClinGen gnomAD
CA344075264 rs1178049411	138	Q>E		No	ClinGen TOPMed
CA344075253 rs1211721310	139	V>A		No	ClinGen gnomAD
rs1434286375 CA344075257	139	V>I		No	ClinGen gnomAD
CA344075232 rs1313956355	142	S>N		No	ClinGen gnomAD
CA35093354 rs375167412	143	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs2275445 CA35093353	144	A>P		No	ClinGen ExAC TOPMed gnomAD
rs2275445 CA1302223	144	A>S		No	ClinGen ExAC TOPMed gnomAD
rs2275445 CA1302224	144	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1484109138 CA344075196	146	Q>*		No	ClinGen gnomAD
TCGA novel	146	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA35093350 rs941683161	147	Q>K		No	ClinGen TOPMed gnomAD
CA344075182 rs1553247236	148	M>V		No	ClinGen Ensembl
rs746514604 CA1302205	149	F>L		No	ClinGen ExAC gnomAD
rs865934027 CA35093349	150	E>Q		No	ClinGen Ensembl
rs35505005 CA1302203	153	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	154	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344075131 rs1293496055	155	T>P		No	ClinGen gnomAD
CA344075125 rs1413037512	156	S>T		No	ClinGen TOPMed
CA1302201 rs778745204	157	A>P		No	ClinGen ExAC gnomAD
rs754733947 CA1302200	160	E>D		No	ClinGen ExAC gnomAD
rs767838915 CA344075083	162	A>P		No	ClinGen ExAC TOPMed gnomAD
rs767838915 CA1302198	162	A>T		No	ClinGen ExAC TOPMed gnomAD
CA344075047 rs773702442	167	S>C		No	ClinGen ExAC TOPMed gnomAD
CA1302197 rs773702442	167	S>G		No	ClinGen ExAC TOPMed gnomAD
rs139595729 CA1302196	169	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1302195 rs764221741	171	V>A		No	ClinGen ExAC gnomAD
rs1188491342 CA344075001	174	R>K		No	ClinGen gnomAD
rs770352804 CA35093348	179	D>G		No	ClinGen Ensembl
TCGA novel	184	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344074931 rs1458177690	184	G>R		No	ClinGen gnomAD
rs910453913 CA35093347	186	I>T		No	ClinGen TOPMed gnomAD
CA1302175 rs752781635	190	A>G		No	ClinGen ExAC TOPMed gnomAD
CA35093251 rs111500245	190	A>T		No	ClinGen TOPMed gnomAD
rs890591356 CA35093250	192	N>D		No	ClinGen Ensembl
rs140645938 CA1302174	192	N>S		No	ClinGen ESP ExAC gnomAD
rs1311843534 CA344074862	193	Q>*		No	ClinGen gnomAD
CA1302173 rs760071291	195	D>Y		No	ClinGen ExAC gnomAD
rs867951836 CA35093249	196	W>L		No	ClinGen Ensembl
VAR_011613	197	I>F		No	UniProt
rs993773906 CA35093248	198	S>G		No	ClinGen TOPMed gnomAD
rs1270520382 CA344074817	199	A>S		No	ClinGen TOPMed gnomAD
CA344074798 rs1285545680	202	P>S		No	ClinGen TOPMed
rs201071799 CA1302172	203	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	207	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761056431 CA1302170	207	R>S		No	ClinGen ExAC gnomAD
rs1010174152 CA35093247	208	I>V		No	ClinGen Ensembl
TCGA novel	209	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1420141414 CA344074741	210	K>R		No	ClinGen gnomAD
CA344074532 rs1571508171	211	Y>H		No	ClinGen Ensembl
CA1302126 rs762268546	212	S>R		No	ClinGen ExAC gnomAD
rs775430311 CA35092790	212	S>T		No	ClinGen Ensembl
CA344074519 rs1409102370	213	E>K		No	ClinGen TOPMed
CA1302125 rs751104681	214	G>V		No	ClinGen ExAC TOPMed gnomAD
CA35092787 rs375856662	217	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA35092788 rs375856662	217	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1292950928 CA344074490	217	R>P		No	ClinGen gnomAD
TCGA novel	217	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	222	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1457950788 CA344074454	222	A>T		No	ClinGen TOPMed
rs1360290648 CA344074449	223	I>V		No	ClinGen gnomAD
TCGA novel	224	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1159584163 CA344074405	229	M>K		No	ClinGen TOPMed gnomAD
CA344074404 rs1159584163	229	M>T		No	ClinGen TOPMed gnomAD
CA1302123 rs762535915	230	I>M		No	ClinGen ExAC gnomAD
rs967509934 CA35092785	232	E>K		No	ClinGen TOPMed gnomAD
rs1248734076 CA344074361	235	I>V		No	ClinGen gnomAD
rs1213930637 CA344074355	236	A>T		No	ClinGen gnomAD
rs1488048601	236	A>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA1302120 rs759436892	242	L>F		No	ClinGen ExAC gnomAD
CA344074310 rs759436892	242	L>V		No	ClinGen ExAC gnomAD
rs200881380 CA1302119	243	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1558012682 CA344074264	247	P>T		No	ClinGen Ensembl
CA1302102 rs185520390	248	M>L		No	ClinGen 1000Genomes ExAC gnomAD
CA344074254 rs1279694709	248	M>R		No	ClinGen gnomAD
CA1302101 rs776369356	250	T>A		No	ClinGen ExAC gnomAD
CA344074233 rs1377451362	251	D>G		No	ClinGen gnomAD
COSM3803245 COSM3803244 COSM3803243 rs1302564487 CA344074227 COSM3803246	252	Q>E	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs760377013 CA1302099	253	G>D		No	ClinGen ExAC TOPMed gnomAD
CA1302100 rs766355155	253	G>R		No	ClinGen ExAC gnomAD
rs1281270229 CA344074208	254	N>D		No	ClinGen TOPMed
rs773059734 CA1302098	255	S>G		No	ClinGen ExAC TOPMed gnomAD
CA1302097 rs768836329	255	S>N		No	ClinGen ExAC gnomAD
TCGA novel	255	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA35092708 rs368049598	256	M>I		No	ClinGen ESP TOPMed gnomAD
rs749561076 CA1302096	256	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	257	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344074151 rs1173082318	259	A>T		No	ClinGen gnomAD
rs1027291966 CA35092707	260	I>V		No	ClinGen Ensembl
TCGA novel	261	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775721003 CA1302095	266	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1558011697	267	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1376309370 CA344074038	269	M>T		No	ClinGen TOPMed
rs769696158 CA35092706	271	I>L		No	ClinGen ExAC TOPMed gnomAD
CA344074016 rs1268610155 COSM901354	271	I>T	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs769696158 CA1302094	271	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1193317807 CA344074010	272	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA35092705 rs938353590	281	Y>F		No	ClinGen TOPMed
rs1197531329 CA344073904	281	Y>N		No	ClinGen gnomAD
rs766225024 CA1302083	283	I>V		No	ClinGen ExAC gnomAD
rs1571462464 CA344073793	284	E>G		No	ClinGen Ensembl
rs760708096 CA1302082	285	N>D		No	ClinGen ExAC gnomAD
rs1378466262 CA344073783	285	N>S		No	ClinGen TOPMed gnomAD
rs1228983394 CA344073697	292	Y>S		No	ClinGen TOPMed
rs770111232 CA1302077	296	I>V		No	ClinGen ExAC TOPMed gnomAD
CA35092515 rs1007767123	298	E>K		No	ClinGen Ensembl
rs1226750299 CA344073635	298	E>V		No	ClinGen Ensembl
rs745929302 CA344073621	299	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1246077586 CA344073616	300	L>*		No	ClinGen TOPMed gnomAD
rs1330468927 CA344073601	301	K>R		No	ClinGen gnomAD
CA35092514 rs953770729	302	T>S		No	ClinGen gnomAD
CA344073579 rs1452428046	303	L>V		No	ClinGen TOPMed
CA35092513 rs868716595	306	H>Y		No	ClinGen Ensembl
rs776809591 CA1302075	307	Q>*		No	ClinGen ExAC gnomAD
CA1302074 rs771316883	308	Q>K		No	ClinGen ExAC
TCGA novel	310	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371022300 CA1302072	311	P>A		No	ClinGen ESP ExAC gnomAD
rs371022300 CA1302073	311	P>T		No	ClinGen ESP ExAC gnomAD
rs367543822 CA35092511	314	E>K		No	ClinGen ESP TOPMed gnomAD
TCGA novel	318	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1302030 rs769500827	320	Q>H		No	ClinGen ExAC gnomAD
CA1302031 rs775195550	320	Q>K		No	ClinGen ExAC gnomAD
CA1302029 rs75981031	321	N>I		No	ClinGen ExAC gnomAD
CA35092049 rs75981031	321	N>S		No	ClinGen ExAC gnomAD
CA1302027 rs146351256 COSM173824	322	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	323	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	324	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200139872 CA1302025	327	E>A		No	ClinGen 1000Genomes ExAC TOPMed
rs200139872 CA35092048	327	E>G		No	ClinGen 1000Genomes ExAC TOPMed

No associated diseases with Q9Y5K5

3 regional properties for Q9Y5K5

Type	Name	Position	InterPro Accession
domain	Peptidase C12, ubiquitin carboxyl-terminal hydrolase	6 - 226	IPR001578
domain	Ubiquitinyl hydrolase-L5	8 - 223	IPR033837
domain	Peptidase C12, C-terminal domain	265 - 309	IPR041507

Functions

		Description
EC Number	3.4.19.12	Omega peptidases
Subcellular Localization	Cytoplasm Nucleus	Associates with the proteasome 19S subunit in the cytoplasm Associates with the INO80 complex in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic proteasome complex	A proteasome complex found in the cytosol of a cell.
Ino80 complex	A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
cysteine-type deubiquitinase activity	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
endopeptidase inhibitor activity	Binds to and stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
proteasome binding	Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
RNA binding	Binding to an RNA molecule or a portion thereof.

20 GO annotations of biological process

Name	Definition
chromatin remodeling	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
DNA recombination	Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
forebrain morphogenesis	The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
lateral ventricle development	The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.
midbrain development	The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
positive regulation of DNA repair	Any process that activates or increases the frequency, rate or extent of DNA repair.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of smoothened signaling pathway	Any process that activates or increases the frequency, rate or extent of smoothened signaling.
positive regulation of telomere maintenance in response to DNA damage	Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage.
protein deubiquitination	The removal of one or more ubiquitin groups from a protein.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of chromosome organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.
regulation of DNA replication	Any process that modulates the frequency, rate or extent of DNA replication.
regulation of DNA strand elongation	Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand.
regulation of embryonic development	Any process that modulates the frequency, rate or extent of embryonic development.
regulation of proteasomal protein catabolic process	Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
telomere maintenance	Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9XSJ0	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Bos taurus (Bovine)	PR
Q7K5N4	calypso	Ubiquitin carboxyl-terminal hydrolase calypso	Drosophila melanogaster (Fruit fly)	PR
Q9WUP7	Uchl5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Mus musculus (Mouse)	PR
Q06AT3	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Sus scrofa (Pig)	PR

10	20	30	40	50	60
MTGNAGEWCL	MESDPGVFTE	LIKGFGCRGA	QVEEIWSLEP	ENFEKLKPVH	GLIFLFKWQP
70	80	90	100	110	120
GEEPAGSVVQ	DSRLDTIFFA	KQVINNACAT	QAIVSVLLNC	THQDVHLGET	LSEFKEFSQS
130	140	150	160	170	180
FDAAMKGLAL	SNSDVIRQVH	NSFARQQMFE	FDTKTSAKEE	DAFHFVSYVP	VNGRLYELDG
190	200	210	220	230	240
LREGPIDLGA	CNQDDWISAV	RPVIEKRIQK	YSEGEIRFNL	MAIVSDRKMI	YEQKIAELQR
250	260	270	280	290	300
QLAEEEPMDT	DQGNSMLSAI	QSEVAKNQML	IEEEVQKLKR	YKIENIRRKH	NYLPFIMELL
310	320
KTLAEHQQLI	PLVEKAKEKQ	NAKKAQETK