Q7K5N4
Gene name |
calypso (CG8445) |
Protein name |
Ubiquitin carboxyl-terminal hydrolase calypso |
Names |
BAP1 homolog |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG8445 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q7K5N4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6CGA | X-ray | 350 A | A/C | 43-404 | PDB |
| 6HGC | X-ray | 302 A | PDB | ||
| AF-Q7K5N4-F1 | Predicted | AlphaFoldDB |
No variants for Q7K5N4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7K5N4 | |||||
No associated diseases with Q7K5N4
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PR-DUB complex | A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| heterochromatin assembly | An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. |
| monoubiquitinated histone H2A deubiquitination | The removal of the ubiquitin group from a monoubiquitinated histone H2A protein. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| specification of segmental identity, abdomen | The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9XSJ0 | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Bos taurus (Bovine) | PR |
| Q9Y5K5 | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Homo sapiens (Human) | PR |
| Q9WUP7 | Uchl5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Mus musculus (Mouse) | PR |
| Q06AT3 | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Sus scrofa (Pig) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNAAGGGSGA | QAAAVAAGNN | SLSHNALLST | ASGATTMPMA | QLADGWLELE | SDPGLFTLLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDFGCHDVQV | EEVYDLQKPI | ESPYGFIFLF | RWIEERRARR | KIVETTAEIF | VKDEEAISSI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FFAQQVVPNS | CATHALLSVL | LNCNENNLQL | GDTLSRLKTH | TKGMSPENKG | LAIGNTPELA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CAHNSHAMPQ | ARRRLERTGA | GVSSCRFTGE | AFHFVSFVPI | NGQLFELDGL | KPYPMNHGGW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDSEDWTDKF | RRVMAERLGI | ATGEQDIRFN | LMAVVPDRRI | AITHKLKMLR | TNQAIVSGTL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QKLLKADEQG | ESGNGDSQRP | DTPTTLLEPS | AFTARDLQSL | LKNLDTEIAI | NEQHLADEND |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RRHMFKVDAS | RRTHNYDKFI | CTFLSMLAHQ | GVLGELVSQH | LLPSKKVSGQ | GAANRISKQS |
| 430 | 440 | 450 | 460 | 470 | |
| TTASAGGSTA | AGTASTPKTQ | QQQAAAAKNG | KSPSKTPGRR | RKGRNKCRKR | K |