Q9XSK7

PR
Gene name
HDGF
Protein name
Hepatoma-derived growth factor
Names
HDGF
Species
Bos taurus (Bovine)
KEGG Pathway
bta:327953
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

171-239 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9XSK7

Entry ID Method Resolution Chain Position Source
AF-Q9XSK7-F1 Predicted AlphaFoldDB

81 variants for Q9XSK7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs471392166 5 N>K No EVA
rs451435944 5 N>S No EVA
rs451435944 5 N>T No EVA
rs433278843 10 Y>D No EVA
rs473447161 23 Y>S No EVA
rs441956234 26 W>G No EVA
rs462453521 27 P>R No EVA
rs476152021 28 A>P No EVA
rs464178865 32 E>K No EVA
rs459175056 35 E>G No EVA
rs432711135 38 V>E No EVA
rs446743935 40 S>L No EVA
rs135504603 41 T>P No EVA
rs466782143 45 Y>N No EVA
rs466567558 59 G>A No EVA
rs480601518 62 D>G No EVA
rs469021103 64 F>L No EVA
rs437715642 69 S>P No EVA
rs457275825 72 K>* No EVA
rs464538862 72 K>N No EVA
rs453272373 82 F>V No EVA
rs473408207 84 E>V No EVA
rs442313373 85 G>R No EVA
rs455997827 88 E>A No EVA
rs476012989 89 I>F No EVA
rs444600972 89 I>M No EVA
rs458328179 90 E>G No EVA
rs477988640 91 N>D No EVA
rs460119435 91 N>K No EVA
rs440064731 91 N>T No EVA
rs480210559 97 A>V No EVA
rs469060210 100 Y>F No EVA
rs469060210 100 Y>S No EVA
rs482720283 101 Q>R No EVA
rs465870734 102 S>C No EVA
rs437321921 104 Q>E No EVA
rs437321921 104 Q>K No EVA
rs448119454 111 E>D No EVA
rs437116336 129 A>P No EVA
rs457194446 138 K>N No EVA
rs432931105 148 K>Q No EVA
rs472720436 158 A>S No EVA
rs441255814 163 E>* No EVA
rs433265302 164 D>G No EVA
rs435899376 167 K>N No EVA
rs446876354 167 K>Q No EVA
rs466950026 167 K>T No EVA
rs476014558 173 E>A No EVA
rs438231728 178 E>V No EVA
rs451796779 179 E>* No EVA
rs471538434 181 E>G No EVA
rs440069900 182 G>W No EVA
rs442686581 185 L>W No EVA
rs482987625 188 E>D No EVA
rs438626300 189 R>G No EVA
rs442413523 193 V>M No EVA
rs478381003 200 T>P No EVA
rs480575648 207 G>A No EVA
rs466986709 207 G>C No EVA
rs466986709 207 G>S No EVA
rs449609684 208 R>Q No EVA
rs469738185 210 P>R No EVA
rs451907656 211 P>T No EVA
rs433682225 213 E>K No EVA
rs453640161 214 E>* No EVA
rs473605137 215 E>* No EVA
rs442424199 215 E>A No EVA
rs455966912 216 E>A No EVA
rs476578188 218 E>A No EVA
rs438665921 218 E>D No EVA
rs478816355 219 E>D No EVA
rs458772825 219 E>K No EVA
rs440552955 223 A>D No EVA
rs460592302 225 K>* No EVA
rs480702305 225 K>R No EVA
rs449333217 228 A>P No EVA
rs469329856 230 A>S No EVA
rs445454162 232 G>A No EVA
rs445454162 232 G>V No EVA
rs465584120 235 D>H No EVA
rs454174860 237 E>* No EVA

No associated diseases with Q9XSK7

2 regional properties for Q9XSK7

Type Name Position InterPro Accession
domain PWWP domain 10 - 90 IPR000313
domain Hepatoma-derived growth factor, PWWP domain 10 - 96 IPR047363

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Secreted, extracellular exosome
  • Secreted by exosomes and is located inside the exosome (By similarity)
  • May also be secreted as free protein via an as yet unknown pathway (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
double-stranded DNA binding Binding to double-stranded DNA.
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

2 GO annotations of biological process

Name Definition
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8MJG1 PSIP1 PC4 and SFRS1-interacting protein Bos taurus (Bovine) PR
Q66T72 PSIP1 PC4 and SFRS1-interacting protein Felis catus (Cat) (Felis silvestris catus) PR
Q5XXA9 PSIP1 Lens epithelium-derived growth factor Gallus gallus (Chicken) PR
Q7Z4V5 HDGFL2 Hepatoma-derived growth factor-related protein 2 Homo sapiens (Human) PR
O75475 PSIP1 PC4 and SFRS1-interacting protein Homo sapiens (Human) PR
Q9Y3E1 HDGFL3 Hepatoma-derived growth factor-related protein 3 Homo sapiens (Human) PR
P51858 HDGF Hepatoma-derived growth factor Homo sapiens (Human) PR
Q99JF8 Psip1 PC4 and SFRS1-interacting protein Mus musculus (Mouse) PR
Q9JMG7 Hdgfl3 Hepatoma-derived growth factor-related protein 3 Mus musculus (Mouse) PR
P51859 Hdgf Hepatoma-derived growth factor Mus musculus (Mouse) PR
Q812D1 Psip1 PC4 and SFRS1-interacting protein Rattus norvegicus (Rat) PR
Q923W4 Hdgfl3 Hepatoma-derived growth factor-related protein 3 Rattus norvegicus (Rat) PR
Q8VHK7 Hdgf Hepatoma-derived growth factor Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP
70 80 90 100 110 120
KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY QSSQKKSCVE EPEPEPEATE
130 140 150 160 170 180
GDGDKKGNAE GSSDEEGKLV IDEPTKEKNE KGALKRRAGD LLEDSPKRPK EAEDLEGEEK
190 200 210 220 230
EGATLEGERP LPVEAEKNST PSEPGSGRGP PQEEEEEEEE EEAAKEDAEA PGLRDHESL