Q923W4
Gene name |
Hdgfl3 (Hdgfrp3, Hrp3) |
Protein name |
Hepatoma-derived growth factor-related protein 3 |
Names |
HRP-3 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:252941 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q923W4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q923W4-F1 | Predicted | AlphaFoldDB |
No variants for Q923W4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q923W4 | |||||
No associated diseases with Q923W4
1 regional properties for Q923W4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PWWP domain | 9 - 89 | IPR000313 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| double-stranded DNA binding | Binding to double-stranded DNA. |
| growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
| transcription coregulator activity | A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
| tubulin binding | Binding to monomeric or multimeric forms of tubulin, including microtubules. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| microtubule polymerization | The addition of tubulin heterodimers to one or both ends of a microtubule. |
| negative regulation of microtubule depolymerization | Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9XSK7 | HDGF | Hepatoma-derived growth factor | Bos taurus (Bovine) | PR |
| Q8MJG1 | PSIP1 | PC4 and SFRS1-interacting protein | Bos taurus (Bovine) | PR |
| Q66T72 | PSIP1 | PC4 and SFRS1-interacting protein | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q5XXA9 | PSIP1 | Lens epithelium-derived growth factor | Gallus gallus (Chicken) | PR |
| P51858 | HDGF | Hepatoma-derived growth factor | Homo sapiens (Human) | PR |
| O75475 | PSIP1 | PC4 and SFRS1-interacting protein | Homo sapiens (Human) | PR |
| Q7Z4V5 | HDGFL2 | Hepatoma-derived growth factor-related protein 2 | Homo sapiens (Human) | PR |
| Q9Y3E1 | HDGFL3 | Hepatoma-derived growth factor-related protein 3 | Homo sapiens (Human) | PR |
| P51859 | Hdgf | Hepatoma-derived growth factor | Mus musculus (Mouse) | PR |
| Q99JF8 | Psip1 | PC4 and SFRS1-interacting protein | Mus musculus (Mouse) | PR |
| Q9JMG7 | Hdgfl3 | Hepatoma-derived growth factor-related protein 3 | Mus musculus (Mouse) | PR |
| Q812D1 | Psip1 | PC4 and SFRS1-interacting protein | Rattus norvegicus (Rat) | PR |
| Q8VHK7 | Hdgf | Hepatoma-derived growth factor | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARPRPREYK | AGDLVFAKMK | GYPHWPARID | ELPEGAVKPP | ANKYPIFFFG | THETAFLGPK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DLFPYKEYKD | KFGKSNKRKG | FNEGLWEIEN | NPGVKFTGYQ | TIQQQSSSET | EGEGGNTADA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSEEEGDRVE | DGKGKRKNEK | GGSKRKKSYT | SKKSSKQSRK | SPGDEDDKDC | KEEENKSSSE |
| 190 | 200 | ||||
| GGDAGNDTRN | TTSDLQKAGE | GT |