AiPD: Autoinhibited Protein Database

P51858

Gene name	HDGF (HMG1L2)
Protein name	Hepatoma-derived growth factor
Names	HDGF, High mobility group protein 1-like 2, HMG-1L2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3068
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

64-240 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

64-240 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for P51858

Entry ID	Method	Resolution	Chain	Position	Source
1RI0	NMR	-	A	1-100	PDB
2NLU	NMR	-	A/B	1-100	PDB
AF-P51858-F1	Predicted				AlphaFoldDB

197 variants for P51858

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1260419652 CA342915299	4	S>A		No	ClinGen TOPMed
CA342915291 rs1490472576	4	S>C		No	ClinGen gnomAD
CA1166721 rs767111801	5	N>S	Variant assessed as Somatic; 0.0001398 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1166720 rs759201444	6	R>W		No	ClinGen ExAC gnomAD
CA342915257 rs1218939382	7	Q>*		No	ClinGen TOPMed
CA1166718 rs774910787	7	Q>P		No	ClinGen ExAC gnomAD
CA342915254 rs774910787	7	Q>R		No	ClinGen ExAC gnomAD
rs771415808 CA1166717	8	K>E		No	ClinGen ExAC gnomAD
rs1202192764 CA342915230	9	E>K		No	ClinGen Ensembl
rs1406464385 CA342915212	10	Y>F		No	ClinGen gnomAD
rs868163154 CA31095050	13	G>W		No	ClinGen Ensembl
rs1225729279 CA342915135	14	D>E		No	ClinGen gnomAD
TCGA novel	16	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	17	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763557184 CA1166716	18	A>P		No	ClinGen ExAC gnomAD
rs1398670576 CA342915051	19	K>R		No	ClinGen gnomAD
rs748138050 CA1166713	26	W>G		No	ClinGen ExAC gnomAD
rs770739734 CA1166691	30	I>V		No	ClinGen ExAC gnomAD
rs1028970679 CA31090793	32	E>K		No	ClinGen gnomAD
rs777519088 CA1166689	33	M>I		No	ClinGen ExAC gnomAD
rs1571543900 CA342912680	35	E>G		No	ClinGen Ensembl
rs1571543889 CA342912663	36	A>P		No	ClinGen Ensembl
CA1166688 rs756060981	36	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	38	V>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1166686 rs150810015	38	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150810015 CA1166685	38	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1321277705 CA342912545	40	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs372321208 CA31090777	43	N>K		No	ClinGen ESP TOPMed
CA1166684 rs751278895	44	K>R		No	ClinGen ExAC gnomAD
rs766089631 CA1166683	45	Y>*		No	ClinGen ExAC gnomAD
CA1166682 rs758093528	46	Q>*		No	ClinGen ExAC gnomAD
TCGA novel	50	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342912360 rs1208696194	51	G>R		No	ClinGen TOPMed
rs1402218484 CA342912338	52	T>P		No	ClinGen gnomAD
rs1385420300 CA342912281	55	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs553464376 CA1166661	58	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	63	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	66	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1339960423 CA342911821	71	E>Q		No	ClinGen gnomAD
CA342911724 rs1277566152	75	K>Q		No	ClinGen gnomAD
rs1315039009 CA342911718	75	K>R		No	ClinGen TOPMed
rs767576468 CA1166657	76	P>H		No	ClinGen ExAC gnomAD
TCGA novel	77	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342911441 rs1424962653	84	E>D		No	ClinGen gnomAD
rs769497614 CA1166654	84	E>K		No	ClinGen ExAC TOPMed gnomAD
rs11556976 CA31090567	90	E>K		No	ClinGen Ensembl
rs913630310 CA31090559	93	P>S		No	ClinGen TOPMed
TCGA novel	94	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	95	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342911188 rs1245243757	96	K>E		No	ClinGen gnomAD
CA342911177 rs1206713192	96	K>M		No	ClinGen gnomAD
CA342911162 rs1571543010	97	A>P		No	ClinGen Ensembl
CA342911146 rs1179207124	98	S>F		No	ClinGen TOPMed
TCGA novel	98	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1196683401 CA342911120	99	G>A		No	ClinGen TOPMed gnomAD
rs779714352 CA1166649	99	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1196683401 CA342911119	99	G>V		No	ClinGen TOPMed gnomAD
rs1393142382 CA342911070	101	Q>R		No	ClinGen TOPMed
CA342910927 rs1350362694	102	S>C		No	ClinGen TOPMed
rs945276882 CA31090170	103	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA342910919 rs1194509996	104	Q>K		No	ClinGen gnomAD
rs1385093355 CA342910910	105	K>Q		No	ClinGen gnomAD
TCGA novel rs148010782 CA1166605	106	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC TOPMed gnomAD NCI-TCGA
rs199809801 CA1166604	108	C>S		No	ClinGen ESP ExAC gnomAD
rs1398083194 CA342910832	110	E>A		No	ClinGen gnomAD
CA342910802 rs1231487248	111	E>A		No	ClinGen TOPMed
CA342910806 rs1178281787	111	E>K		No	ClinGen TOPMed gnomAD
rs1178281787 CA342910812	111	E>Q		No	ClinGen TOPMed gnomAD
rs748544475 CA1166603	113	E>K		No	ClinGen ExAC gnomAD
CA1166602 rs369237103	114	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs183479594 CA31090139	114	P>L		No	ClinGen 1000Genomes
rs369237103 CA342910749	114	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1166601 rs200564111	116	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1215675835 CA342910698	117	E>K		No	ClinGen TOPMed
CA342910673 rs1238291674	118	A>P		No	ClinGen gnomAD
rs145403460 CA1166599	118	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1487050392 CA342910632	120	E>A		No	ClinGen TOPMed
CA342910617 rs758392974	121	G>C		No	ClinGen ExAC TOPMed gnomAD
rs750720441 CA1166597	121	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs758392974 CA1166598	121	G>R		No	ClinGen ExAC TOPMed gnomAD
CA342910614 rs758392974	121	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	121	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1166595 rs562299927	123	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1027685958 CA31090128	123	G>R		No	ClinGen TOPMed gnomAD
CA342910574 rs1027685958	123	G>S		No	ClinGen TOPMed gnomAD
TCGA novel	126	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1265218607 CA342910500	127	G>R		No	ClinGen Ensembl
rs767358031 CA1166593	128	N>S		No	ClinGen ExAC gnomAD
COSM1209424 rs1374562419 COSM1209425 CA342910362	134	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
COSM1235643 rs774146430 COSM1235642 CA1166591	135	E>K	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1166588 rs143813161	140	V>F		No	ClinGen ExAC TOPMed gnomAD
CA31090107 rs143813161	140	V>I		No	ClinGen ExAC TOPMed gnomAD
rs544419635 CA1166587	142	D>E		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	142	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1558031720 CA342910229	142	D>Y		No	ClinGen Ensembl
rs776984250 CA1166585	144	P>A		No	ClinGen ExAC gnomAD
CA1166583 rs374787693	147	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs772230975 CA1166581	148	K>E		No	ClinGen ExAC gnomAD
CA342910087 rs903307133	149	N>K		No	ClinGen TOPMed
CA1166579 rs745973675	150	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1189590680 CA342910050	151	K>R		No	ClinGen TOPMed
CA342910024 rs1287090650	152	G>A		No	ClinGen gnomAD
rs757562304 CA342910009	153	A>E		No	ClinGen ExAC TOPMed gnomAD
CA342910006 rs757562304	153	A>G		No	ClinGen ExAC TOPMed gnomAD
CA342910017 rs1571540538	153	A>T		No	ClinGen Ensembl
rs757562304 COSM1583525 COSM897354 CA1166577	153	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA31090039 rs893718127	158	A>G		No	ClinGen Ensembl
CA342909931 rs6675747	158	A>P		No	ClinGen TOPMed gnomAD
CA31090043 rs6675747	158	A>T		No	ClinGen TOPMed gnomAD
CA342909900 rs1285818036	159	G>E		No	ClinGen gnomAD
TCGA novel	160	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1166574 rs151063654	162	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA1166573 rs369865214	163	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA342909743 rs1388911023	164	D>N		No	ClinGen TOPMed
TCGA novel	167	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1277135271 CA342909695	168	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs147426380 CA1166555	168	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	170	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1166553 rs372280917	170	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1166551 rs750355824	171	E>A		No	ClinGen ExAC gnomAD
TCGA novel	171	E>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342909615 rs1279683775	172	A>V		No	ClinGen TOPMed
CA342909575 rs1571539718	174	N>T		No	ClinGen Ensembl
rs187134455 CA1166550	174	N>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761289151 CA342909561	175	P>A		No	ClinGen ExAC gnomAD
CA1166549 rs761289151	175	P>T		No	ClinGen ExAC gnomAD
COSM676381 rs200554626 COSM1145975 CA342909546	176	E>K	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs200554626 CA1166548	176	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1166547 rs73002716	177	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA31089792 rs374107346	178	E>V		No	ClinGen Ensembl
TCGA novel	179	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1287572977 CA342909469	181	E>Q		No	ClinGen gnomAD
TCGA novel	182	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1166544 rs767851811	184	T>N		No	ClinGen ExAC gnomAD
CA342909400 rs1445057109	186	E>G		No	ClinGen TOPMed
rs760182397 CA1166543	187	V>A		No	ClinGen ExAC TOPMed gnomAD
CA1166541 rs771176911	191	L>F		No	ClinGen ExAC TOPMed gnomAD
rs749411435 CA1166540	191	L>R		No	ClinGen ExAC gnomAD
CA342909246 rs1164242519	192	P>L		No	ClinGen TOPMed
CA342909249 rs1571539539	192	P>S		No	ClinGen Ensembl
rs773295545 CA1166539	193	M>R		No	ClinGen ExAC gnomAD
CA342909178 rs1571539486	195	V>G		No	ClinGen Ensembl
CA342909185 rs1435050623	195	V>L		No	ClinGen TOPMed gnomAD
CA342909186 rs1435050623	195	V>M		No	ClinGen TOPMed gnomAD
CA31089737 rs375503842	198	N>H		No	ClinGen ESP TOPMed
CA342909121 rs1324427322	198	N>S		No	ClinGen gnomAD
CA342909104 rs1467667101	199	S>T		No	ClinGen gnomAD
rs1558031103 CA342909073	200	T>N		No	ClinGen Ensembl
CA342909079 rs1571539387	200	T>P		No	ClinGen Ensembl
CA1166534 rs4399146	201	P>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_061209 rs4399146 CA1166533	201	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA31089718 rs4399146	201	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1299657068 CA342909056	201	P>S		No	ClinGen TOPMed
TCGA novel	202	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342909043 rs1427511709	202	S>T		No	ClinGen gnomAD
rs757142792 CA1166532	203	E>D		No	ClinGen ExAC gnomAD
CA342908984 rs1477716012	204	P>S		No	ClinGen gnomAD
CA31089681 rs11556974	205	G>D		No	ClinGen Ensembl
rs375226201 CA1166529	205	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs752385621 CA1166528	206	S>C		No	ClinGen ExAC gnomAD
CA1166526 rs759951478	207	G>A		No	ClinGen ExAC TOPMed gnomAD
rs1172088312 CA342908939	207	G>R		No	ClinGen gnomAD
rs562259611 CA1166525	208	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1166523 rs201482955	208	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1138657 rs201482955 CA1166522 COSM529522	208	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA1166524 rs562259611	208	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	209	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342908908 rs1342204024	209	G>R		No	ClinGen gnomAD
CA342908877 rs1446940657	211	P>L		No	ClinGen gnomAD
CA31089644 rs1044914054	212	Q>R		No	ClinGen TOPMed gnomAD
CA1166518 rs776889774	213	E>A		No	ClinGen ExAC TOPMed
TCGA novel	214	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342908770 rs565033550	215	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA1166516 rs565033550	215	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA342908708 rs4437869 CA342908710	216	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1166515 rs778627953	216	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1160771946 CA342908696	217	E>*		No	ClinGen TOPMed
CA342908687 rs1178952978	217	E>D		No	ClinGen TOPMed gnomAD
CA342908694 rs1361542731	217	E>G		No	ClinGen TOPMed
CA342908693 rs1361542731	217	E>V		No	ClinGen TOPMed
rs1571538826 CA342908663	218	E>D		No	ClinGen Ensembl
rs1403742404 CA342908635	219	D>E		No	ClinGen TOPMed
rs573185750 CA1166507	221	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1333859886 CA342908473	226	K>N		No	ClinGen TOPMed
TCGA novel	228	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342907614 rs1309763240	230	E>G		No	ClinGen TOPMed
CA342907581 rs1346878533	231	A>S		No	ClinGen TOPMed
TCGA novel	231	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA31089604 rs530319024	232	P>L		No	ClinGen gnomAD
rs1210507077 CA342907549	232	P>S		No	ClinGen TOPMed
TCGA novel	233	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1166503 rs767312799	233	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1484279318 CA342907515	234	I>N		No	ClinGen TOPMed
CA342907517 rs1484469926	234	I>V		No	ClinGen gnomAD
TCGA novel	237	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1166502 rs200493622	237	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA342907353 rs1309086616	239	S>G		No	ClinGen TOPMed gnomAD

No associated diseases with P51858

No regional properties for P51858

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P51858

Functions

		Description
EC Number
Subcellular Localization	[Isoform 1]: Nucleus Cytoplasm Secreted, extracellular exosome	Secreted by exosomes and is located inside the exosome (PubMed:27926477) May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
collagen-containing extracellular matrix	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription repressor complex	A protein complex that possesses activity that prevents or downregulates transcription.

12 GO annotations of molecular function

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
double-stranded DNA binding	Binding to double-stranded DNA.
growth factor activity	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
heparin binding	Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
nucleotide binding	Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
transcription coregulator activity	A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
transcription corepressor binding	Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
tubulin binding	Binding to monomeric or multimeric forms of tubulin, including microtubules.

8 GO annotations of biological process

Name	Definition
cellular response to interleukin-7	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus.
negative regulation of neuron apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of cell division	Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein localization to nucleus	A process in which a protein transports or maintains the localization of another protein to the nucleus.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8MJG1	PSIP1	PC4 and SFRS1-interacting protein	Bos taurus (Bovine)	PR
Q9XSK7	HDGF	Hepatoma-derived growth factor	Bos taurus (Bovine)	PR
Q66T72	PSIP1	PC4 and SFRS1-interacting protein	Felis catus (Cat) (Felis silvestris catus)	PR
Q5XXA9	PSIP1	Lens epithelium-derived growth factor	Gallus gallus (Chicken)	PR
O75475	PSIP1	PC4 and SFRS1-interacting protein	Homo sapiens (Human)	PR
Q7Z4V5	HDGFL2	Hepatoma-derived growth factor-related protein 2	Homo sapiens (Human)	PR
Q9Y3E1	HDGFL3	Hepatoma-derived growth factor-related protein 3	Homo sapiens (Human)	PR
Q99JF8	Psip1	PC4 and SFRS1-interacting protein	Mus musculus (Mouse)	PR
Q9JMG7	Hdgfl3	Hepatoma-derived growth factor-related protein 3	Mus musculus (Mouse)	PR
P51859	Hdgf	Hepatoma-derived growth factor	Mus musculus (Mouse)	PR
Q812D1	Psip1	PC4 and SFRS1-interacting protein	Rattus norvegicus (Rat)	PR
Q923W4	Hdgfl3	Hepatoma-derived growth factor-related protein 3	Rattus norvegicus (Rat)	PR
Q8VHK7	Hdgf	Hepatoma-derived growth factor	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSRSNRQKEY	KCGDLVFAKM	KGYPHWPARI	DEMPEAAVKS	TANKYQVFFF	GTHETAFLGP
70	80	90	100	110	120
KDLFPYEESK	EKFGKPNKRK	GFSEGLWEIE	NNPTVKASGY	QSSQKKSCVE	EPEPEPEAAE
130	140	150	160	170	180
GDGDKKGNAE	GSSDEEGKLV	IDEPAKEKNE	KGALKRRAGD	LLEDSPKRPK	EAENPEGEEK
190	200	210	220	230
EAATLEVERP	LPMEVEKNST	PSEPGSGRGP	PQEEEEEEDE	EEEATKEDAE	APGIRDHESL