Q9XIK6
PR
Gene name |
SNL6 (At1g10450, T10O24.5) |
Protein name |
Paired amphipathic helix protein Sin3-like 6 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G10450 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9XIK6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9XIK6-F1 | Predicted | AlphaFoldDB |
73 variants for Q9XIK6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH10908179 | 23 | F>L | No | 1000Genomes | |
| tmp_1_3432267_T_A | 36 | C>* | No | 1000Genomes | |
| ENSVATH00016020 | 44 | G>R | No | 1000Genomes | |
| tmp_1_3432337_C_A | 60 | H>N | No | 1000Genomes | |
| ENSVATH10908184 | 79 | L>V | No | 1000Genomes | |
| tmp_1_3432604_C_A | 97 | H>Q | No | 1000Genomes | |
| ENSVATH10908315 | 112 | E>D | No | 1000Genomes | |
| tmp_1_3432810_A_G | 128 | K>E | No | 1000Genomes | |
| ENSVATH04549608 | 149 | Y>H | No | 1000Genomes | |
| tmp_1_3432927_A_G | 167 | K>E | No | 1000Genomes | |
| ENSVATH13875391 | 217 | G>A | No | 1000Genomes | |
| tmp_1_3433353_G_A | 242 | A>T | No | 1000Genomes | |
| tmp_1_3433396_C_T | 256 | S>F | No | 1000Genomes | |
| tmp_1_3434018_A_T | 313 | T>S | No | 1000Genomes | |
| ENSVATH04549618 | 324 | G>S | No | 1000Genomes | |
| tmp_1_3434746_A_T | 440 | N>I | No | 1000Genomes | |
| ENSVATH01032245 | 455 | H>Y | No | 1000Genomes | |
| ENSVATH04549626 | 476 | M>V | No | 1000Genomes | |
| ENSVATH01032246 | 488 | P>L | No | 1000Genomes | |
| tmp_1_3435057_C_T | 513 | A>V | No | 1000Genomes | |
| ENSVATH04549627 | 555 | K>R | No | 1000Genomes | |
| ENSVATH04549628 | 571 | L>S | No | 1000Genomes | |
| ENSVATH04549630 | 587 | E>K | No | 1000Genomes | |
| tmp_1_3435557_C_T | 606 | S>L | No | 1000Genomes | |
| ENSVATH04549631 | 621 | F>C | No | 1000Genomes | |
| tmp_1_3435629_A_T | 630 | N>I | No | 1000Genomes | |
| ENSVATH10908538 | 630 | N>Y | No | 1000Genomes | |
| ENSVATH04549632 | 651 | A>T | No | 1000Genomes | |
| ENSVATH04549633 | 658 | G>V | No | 1000Genomes | |
| ENSVATH04549634 | 663 | H>Y | No | 1000Genomes | |
| ENSVATH13875417 | 668 | K>I | No | 1000Genomes | |
| tmp_1_3435753_C_G | 671 | S>R | No | 1000Genomes | |
| tmp_1_3435779_G_A | 680 | S>N | No | 1000Genomes | |
| ENSVATH00016031 | 694 | T>I | No | 1000Genomes | |
| ENSVATH04549636 | 695 | A>T | No | 1000Genomes | |
| ENSVATH13875418 | 702 | D>G | No | 1000Genomes | |
| tmp_1_3436061_A_T | 711 | I>F | No | 1000Genomes | |
| tmp_1_3436066_G_C | 712 | Q>H | No | 1000Genomes | |
| tmp_1_3436068_C_A,T | 713 | S>F | No | 1000Genomes | |
| tmp_1_3436068_C_A,T | 713 | S>Y | No | 1000Genomes | |
| ENSVATH04549638 | 719 | P>T | No | 1000Genomes | |
| tmp_1_3436136_G_T | 736 | A>S | No | 1000Genomes | |
| tmp_1_3436142_G_A | 738 | V>M | No | 1000Genomes | |
| tmp_1_3436146_A_G | 739 | E>G | No | 1000Genomes | |
| tmp_1_3436149_A_C | 740 | K>T | No | 1000Genomes | |
| tmp_1_3436184_G_C | 752 | A>P | No | 1000Genomes | |
| tmp_1_3436191_G_T | 754 | R>L | No | 1000Genomes | |
| ENSVATH00016035 | 763 | G>R | No | 1000Genomes | |
| ENSVATH00016036 | 768 | K>R | No | 1000Genomes | |
| tmp_1_3436287_G_A | 786 | C>Y | No | 1000Genomes | |
| ENSVATH01032249 | 800 | D>N | No | 1000Genomes | |
| tmp_1_3436347_A_T | 806 | H>L | No | 1000Genomes | |
| ENSVATH04549639 | 811 | N>D | No | 1000Genomes | |
| tmp_1_3436374_C_G | 815 | A>G | No | 1000Genomes | |
| ENSVATH13875420 | 829 | E>K | No | 1000Genomes | |
| ENSVATH01032250 | 835 | M>V | No | 1000Genomes | |
| ENSVATH13875421 | 840 | R>C | No | 1000Genomes | |
| tmp_1_3436457_G_A | 843 | V>M | No | 1000Genomes | |
| ENSVATH04549641 | 852 | Q>E | No | 1000Genomes | |
| tmp_1_3436493_G_A | 855 | D>N | No | 1000Genomes | |
| ENSVATH01032251 | 859 | A>T | No | 1000Genomes | |
| ENSVATH04549642 | 863 | R>Q | No | 1000Genomes | |
| ENSVATH13875422 | 888 | N>H | No | 1000Genomes | |
| ENSVATH04549643 | 908 | M>V | No | 1000Genomes | |
| tmp_1_3436828_C_T | 936 | P>L | No | 1000Genomes | |
| tmp_1_3436971_G_T | 958 | E>D | No | 1000Genomes | |
| ENSVATH01032254 | 985 | H>Y | No | 1000Genomes | |
| ENSVATH10908747 | 986 | S>A | No | 1000Genomes | |
| tmp_1_3437393_A_G | 1039 | T>A | No | 1000Genomes | |
| tmp_1_3437397_G_A | 1040 | R>H | No | 1000Genomes | |
| ENSVATH10908748 | 1061 | E>K | No | 1000Genomes | |
| ENSVATH04549650 | 1118 | R>K | No | 1000Genomes | |
| ENSVATH04549653 | 1168 | L>F | No | 1000Genomes |
No associated diseases with Q9XIK6
4 regional properties for Q9XIK6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Paired amphipathic helix | 79 - 148 | IPR003822-1 |
| repeat | Paired amphipathic helix | 162 - 232 | IPR003822-2 |
| domain | Histone deacetylase interacting domain | 349 - 449 | IPR013194 |
| domain | Sin3, C-terminal | 893 - 1136 | IPR031693 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| histone deacetylase complex | A protein complex that possesses histone deacetylase activity. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| histone deacetylation | The modification of histones by removal of acetyl groups. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96ST3 | SIN3A | Paired amphipathic helix protein Sin3a | Homo sapiens (Human) | PR |
| O75182 | SIN3B | Paired amphipathic helix protein Sin3b | Homo sapiens (Human) | PR |
| Q62141 | Sin3b | Paired amphipathic helix protein Sin3b | Mus musculus (Mouse) | PR |
| Q60520 | Sin3a | Paired amphipathic helix protein Sin3a | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRDLLLGTTI | PSYFSWLGLF | PRFLVWFGFL | KASFFCSSRN | QSAGESGRRL | KMKRAREDVH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TDTQKRKPEV | SSRGETNKLP | RTIDALTYLK | AVKDIFHDNK | EKYESFLELM | KEFKAQTIDT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NGVIERIKVL | FKGYRDLLLG | FNTFLPKGYK | ITLLPEEEKP | KIRVDFKDAI | GFVTKIKTRF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GDDEHAYKRF | LDILNLYRKE | KKSISEVYEE | VTMLFKGHED | LLMEFVNFLP | NCPESAPSTK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NAVPRHKGTA | TTAMHSDKKR | KQRCKLEDYS | GHSDQREDGD | ENLVTCSADS | PVGEGQPGYF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RDYENREDTE | TDTADRTEKS | AASGSQDIGN | HKSTTKYVGT | PINELDLSEC | TQCTPSYRLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PKDYAVEIPS | YRNTLGKKTL | NDHLVSVTSG | SEDYSFSHMR | KNQYEESLFR | CEDDRYEMDM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLGSVSSAIK | QVEILLEKMN | NNTISVDSTI | CIEKHLSAMN | LRCIERLYGD | NGLDVMDLLK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KNMHSALPVI | LTRLKQKQEE | WARCHSDFQK | VWAEVYAKNH | HKSLDHRSFY | FKQQDSKNLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TKCLVAEVKD | ISEKKHQEDL | LQAIAVRVMP | LFTPDLEFNY | CDTQIHEDLY | LLIKYYCEEI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CATEQSDKVM | KLWITFLEPI | FGILSRSQDN | LALEDVSKLK | NNRELQDACL | AVKETASGSN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RKHPISPKRL | SKDNTKMQGS | SSREDVSANI | KVKTAQPDKL | QDDAAMTNEV | IQSSKFVSPK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NDQIMEDEGN | HMVNAASVEK | HELEEGELSP | TASREQSNFE | VNGQNAFKPL | QKVTDNVRSN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KDKQSCDKKG | AKNKTRAEDD | KQENCHKLSE | NNKTASEMLV | SGTKVSCHEE | NNRVMNCNGR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GSVAGEMANG | NQGEDGSFAF | SERFLQTVKP | VAKHLSWPLQ | ASETCSQNDS | QVFYGNDSYY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VLFRLHQMLY | ERIQTAKKHS | EKKWKAADNT | TPDSYPRFMD | ALYNLLDGSI | DNTKFEDECR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AIFGAQSYVL | FTLDKLVQKF | VKHLHSVASD | ETDTKLLQLH | AYENYRKPGK | FFDLVYHENA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| CALLHEANIY | RIRYSSEGTR | LSIQLMNSGN | NQLEVMGVAM | EPAFADYLQN | KCLKSVNDEE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| NHGLFLNRNK | KKFTSLDESR | GMPVAMERLN | IINEMECRMA | CSSSKVKYVA | NTSDLLYRSK |
| 1150 | 1160 | 1170 | |||
| QGKPNSRVSE | ILKQRRISRF | HIMLNCRLCA | LPL |