Q62141
PR
Gene name |
Sin3b (Kiaa0700) |
Protein name |
Paired amphipathic helix protein Sin3b |
Names |
Histone deacetylase complex subunit Sin3b, Transcriptional corepressor Sin3b |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20467 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
51 variants for Q62141
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388944180 | 21 | R>C | No | EVA | |
| rs3388992246 | 81 | Q>* | No | EVA | |
| rs3388979573 | 109 | G>A | No | EVA | |
| rs3388995999 | 109 | G>C | No | EVA | |
| rs3388973636 | 110 | K>N | No | EVA | |
| rs3388989044 | 114 | Q>H | No | EVA | |
| rs3388990109 | 130 | G>W | No | EVA | |
| rs3388991952 | 160 | Y>H | No | EVA | |
| rs3399175088 | 185 | Y>* | No | EVA | |
| rs3399258792 | 185 | Y>C | No | EVA | |
| rs3399457190 | 186 | Q>* | No | EVA | |
| rs3388944217 | 271 | A>V | No | EVA | |
| rs3388990077 | 320 | R>C | No | EVA | |
| rs3388988799 | 326 | N>K | No | EVA | |
| rs3388944235 | 368 | M>I | No | EVA | |
| rs3388985684 | 439 | Y>C | No | EVA | |
| rs3388996008 | 443 | L>R | No | EVA | |
| rs3388973659 | 513 | E>D | No | EVA | |
| rs3388973612 | 515 | I>V | No | EVA | |
| rs3388992421 | 526 | V>M | No | EVA | |
| rs3399343690 | 532 | R>S | No | EVA | |
| rs3399344543 | 535 | A>G | No | EVA | |
| rs3388988807 | 548 | N>Y | No | EVA | |
| rs3388988814 | 563 | L>Q | No | EVA | |
| rs3388964048 | 564 | D>Y | No | EVA | |
| rs3388968037 | 594 | H>Q | No | EVA | |
| rs253357110 | 672 | D>E | No | EVA | |
| rs864299805 | 697 | A>V | No | EVA | |
| rs3388944191 | 714 | A>P | No | EVA | |
| rs3388973663 | 726 | Q>R | No | EVA | |
| rs3398815917 | 736 | Y>* | No | EVA | |
| rs3388991969 | 782 | E>D | No | EVA | |
| rs3388944232 | 791 | M>V | No | EVA | |
| rs3388992424 | 812 | M>I | No | EVA | |
| rs3388997542 | 815 | I>V | No | EVA | |
| rs3388973611 | 846 | V>G | No | EVA | |
| rs3388979488 | 854 | Q>H | No | EVA | |
| rs3388985630 | 897 | R>S | No | EVA | |
| rs3388991957 | 908 | L>M | No | EVA | |
| rs3388997465 | 937 | A>T | No | EVA | |
| rs3388973630 | 957 | K>E | No | EVA | |
| rs3388964010 | 1004 | I>F | No | EVA | |
| rs3388988824 | 1011 | M>I | No | EVA | |
| rs3388988798 | 1044 | E>K | No | EVA | |
| rs3388992228 | 1047 | V>L | No | EVA | |
| rs3388984735 | 1048 | T>A | No | EVA | |
| rs3388984728 | 1055 | V>M | No | EVA | |
| rs3388968068 | 1063 | E>D | No | EVA | |
| rs3388988996 | 1076 | T>I | No | EVA | |
| rs3388973608 | 1090 | Q>E | No | EVA | |
| rs3388992249 | 1095 | P>H | No | EVA |
No associated diseases with Q62141
5 regional properties for Q62141
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Paired amphipathic helix | 30 - 100 | IPR003822-1 |
| repeat | Paired amphipathic helix | 145 - 230 | IPR003822-2 |
| repeat | Paired amphipathic helix | 283 - 360 | IPR003822-3 |
| domain | Histone deacetylase interacting domain | 384 - 484 | IPR013194 |
| domain | Sin3, C-terminal | 712 - 1011 | IPR031693 |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| autosome | Any chromosome other than a sex chromosome. |
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| histone deacetylase complex | A protein complex that possesses histone deacetylase activity. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Sin3 complex | A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. |
| X chromosome | The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males. |
| XY body | A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. |
| Y chromosome | The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiac muscle tissue development | The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. |
| histone deacetylation | The modification of histones by removal of acetyl groups. |
| negative regulation of cell cycle | Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| skeletal muscle tissue development | The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96ST3 | SIN3A | Paired amphipathic helix protein Sin3a | Homo sapiens (Human) | PR |
| O75182 | SIN3B | Paired amphipathic helix protein Sin3b | Homo sapiens (Human) | PR |
| Q60520 | Sin3a | Paired amphipathic helix protein Sin3a | Mus musculus (Mouse) | PR |
| Q9XIK6 | SNL6 | Paired amphipathic helix protein Sin3-like 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHAGSGGSA | GRGFGGSRWG | RSGSGGHEKL | PVHVEDALTY | LDQVKIRFGS | DPATYNGFLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IMKEFKSQSI | DTPGVIRRVS | QLFHEHPDLI | VGFNAFLPLG | YRIDIPKNGK | LNIQSPLSSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DNSHSHGDCG | EDFKQMSYKE | DRGQVPLESD | SVEFNNAISY | VNKIKTRFLD | HPEIYRSFLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILHTYQKEQL | HTKGRPFRGM | SEEEVFTEVA | NLFRGQEDLL | SEFGQFLPEA | KRSLFTGNGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CEMNSGQKNE | EKSLEHNKKR | SRPSLLRPVS | APAKKKMKLR | GTKDLSIAAV | GKYGTLQEFS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FFDKVRRVLK | SQEVYENFLR | CIALFNQELV | SGSELLQLVS | PFLGKFPELF | AQFKSFLGVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELSFAPPMSD | RSGDGISREI | DYASCKRIGS | SYRALPKTYQ | QPKCSGRTAI | CKEVLNDTWV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SFPSWSEDST | FVSSKKTPYE | EQLHRCEDER | FELDVVLETN | LATIRVLESV | QKKLSRMAPE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DQEKLRLDDC | LGGTSEVIQR | RAIHRIYGDK | APEVIESLKR | NPATAVPVVL | KRLKAKEEEW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| REAQQGFNKI | WREQYEKAYL | KSLDHQAVNF | KQNDTKALRS | KSLLNEIESV | YDEHQEQHSE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GRSAPSSEPH | LIFVYEDRQI | LEDAAALISY | YVKRQPAIQK | EDQGTIRQLL | HRFLPSLFFS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QQCPGTSDDS | ADERDRDRDS | AEPERRRPTD | EKPPADASPE | PPKVLDDVYS | LFFANNNWYF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FLRLHQTLCA | RLLKIYRQAQ | KQLLEHRREQ | EREQLLCEGR | REKAADPAME | LRLKQPSEVE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LEEYYPAFLD | MVRSLLEGSI | DPTQYEDTLR | EMFTIHAYIG | FTMDKLVQNI | ARQLHHLVSD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DVCLKVVELY | LNEQQRGAAG | GNLSSRCVRA | ARETSYQWKA | ERCMADENCF | KVMFLQRRGQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VIMTIELLDT | EEAQTEDPVE | VQHLARYVEQ | YVGSEGASSS | STEGFLLKPV | FLQRNLKKFR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RWQCEQVRAM | RGEAKSSWKR | LMGVESACDV | DCRFRLGTHK | MVFIVNSEDY | MYRRGTLCRA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KQVQPLVLLR | HHRHFEEWHG | RWLEDNVTVA | AAGLVQDWLM | GEEEEDMVPC | KTLCETAHVH |
| 1090 | |||||
| GLPVTRYRVQ | YSRRPASP |