Q9XEC4
Gene name |
APA3 (At4g04460, T26N6.7) |
Protein name |
Aspartic proteinase A3 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G04460 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9XEC4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9XEC4-F1 | Predicted | AlphaFoldDB |
58 variants for Q9XEC4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH10716642 | 6 | Q>K | No | 1000Genomes | |
| tmp_4_2225262_G_A | 11 | V>M | No | 1000Genomes | |
| tmp_4_2225278_G_A | 16 | C>Y | No | 1000Genomes | |
| ENSVATH02652606 | 18 | I>T | No | 1000Genomes | |
| tmp_4_2225286_C_T | 19 | L>F | No | 1000Genomes | |
| ENSVATH10716643 | 20 | I>L | No | 1000Genomes | |
| ENSVATH13932027 | 28 | N>D | No | 1000Genomes | |
| ENSVATH06466681 | 43 | D>H | No | 1000Genomes | |
| ENSVATH06466682 | 45 | S>N | No | 1000Genomes | |
| ENSVATH10716644 | 49 | A>G | No | 1000Genomes | |
| tmp_4_2225383_A_T | 51 | Q>L | No | 1000Genomes | |
| ENSVATH10716675 | 52 | L>I | No | 1000Genomes | |
| tmp_4_2225397_A_T | 56 | N>Y | No | 1000Genomes | |
| ENSVATH00462443 | 67 | F>L | No | 1000Genomes | |
| tmp_4_2225436_C_G | 69 | L>V | No | 1000Genomes | |
| ENSVATH06466683 | 70 | N>K | No | 1000Genomes | |
| ENSVATH02652607 | 71 | D>N | No | 1000Genomes | |
| tmp_4_2225447_A_C | 72 | E>D | No | 1000Genomes | |
| tmp_4_2225445_G_A | 72 | E>K | No | 1000Genomes | |
| ENSVATH06466685 | 77 | V>I | No | 1000Genomes | |
| ENSVATH06466686 | 90 | D>E | No | 1000Genomes | |
| tmp_4_2225578_C_A | 116 | T>N | No | 1000Genomes | |
| ENSVATH06466699 | 134 | Q>H | No | 1000Genomes | |
| tmp_4_2225753_A_G | 140 | K>R | No | 1000Genomes | |
| tmp_4_2225960_A_G | 159 | S>G | No | 1000Genomes | |
| ENSVATH10716683 | 160 | N>I | No | 1000Genomes | |
| ENSVATH02652617 | 171 | K>R | No | 1000Genomes | |
| ENSVATH13932034 | 183 | G>D | No | 1000Genomes | |
| ENSVATH02652623 | 187 | L>V | No | 1000Genomes | |
| tmp_4_2226164_A_G | 200 | K>E | No | 1000Genomes | |
| ENSVATH06466711 | 200 | K>R | No | 1000Genomes | |
| ENSVATH10716736 | 204 | V>I | No | 1000Genomes | |
| tmp_4_2226291_G_A | 214 | M>I | No | 1000Genomes | |
| ENSVATH06466715 | 221 | K>N | No | 1000Genomes | |
| tmp_4_2226317_C_A | 223 | P>Q | No | 1000Genomes | |
| tmp_4_2226328_T_C | 227 | F>L | No | 1000Genomes | |
| tmp_4_2226341_G_A | 231 | R>H | No | 1000Genomes | |
| ENSVATH06466717 | 233 | P>S | No | 1000Genomes | |
| tmp_4_2226358_G_A | 237 | E>K | No | 1000Genomes | |
| ENSVATH06466720 | 249 | K>T | No | 1000Genomes | |
| ENSVATH06466722 | 252 | K>N | No | 1000Genomes | |
| ENSVATH02652629 | 286 | G>D | No | 1000Genomes | |
| ENSVATH00462448 | 313 | G>R | No | 1000Genomes | |
| tmp_4_2226799_A_T | 327 | D>V | No | 1000Genomes | |
| tmp_4_2226811_A_G | 331 | K>R | No | 1000Genomes | |
| tmp_4_2226831_C_G | 338 | L>V | No | 1000Genomes | |
| ENSVATH10716768 | 343 | P>L | No | 1000Genomes | |
| ENSVATH06466735 | 357 | G>D | No | 1000Genomes | |
| tmp_4_2226969_A_G | 358 | T>A | No | 1000Genomes | |
| tmp_4_2227053_T_A | 363 | M>K | No | 1000Genomes | |
| tmp_4_2227133_G_A | 390 | V>M | No | 1000Genomes | |
| tmp_4_2227155_C_G | 397 | T>S | No | 1000Genomes | |
| tmp_4_2227188_A_T | 408 | Y>F | No | 1000Genomes | |
| tmp_4_2227339_C_T | 432 | S>L | No | 1000Genomes | |
| ENSVATH13932069 | 441 | G>S | No | 1000Genomes | |
| tmp_4_2227395_G_A | 451 | D>N | No | 1000Genomes | |
| tmp_4_2227499_A_T | 456 | I>F | No | 1000Genomes | |
| tmp_4_2227550_A_G | 473 | I>V | No | 1000Genomes |
No associated diseases with Q9XEC4
8 regional properties for Q9XEC4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Aspartic peptidase, active site | 102 - 113 | IPR001969-1 |
| active_site | Aspartic peptidase, active site | 289 - 300 | IPR001969-2 |
| domain | Saposin-like type B, region 1 | 381 - 417 | IPR007856 |
| domain | Saposin B type, region 2 | 321 - 353 | IPR008138 |
| domain | Saposin B type domain | 317 - 357 | IPR008139-1 |
| domain | Saposin B type domain | 378 - 419 | IPR008139-2 |
| domain | Peptidase family A1 domain | 86 - 507 | IPR033121 |
| domain | Phytepsin | 77 - 506 | IPR033869 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartic-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| response to cadmium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGTRFQSFLL | VFLLSCLILI | STASCERNGD | GTIRIGLKKR | KLDRSNRLAS | QLFLKNRGSH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WSPKHYFRLN | DENADMVPLK | NYLDAQYYGD | ITIGTPPQKF | TVIFDTGSSN | LWIPSTKCYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SVACYFHSKY | KASQSSSYRK | NGKPASIRYG | TGAISGYFSN | DDVKVGDIVV | KEQEFIEATS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EPGITFLLAK | FDGILGLGFK | EISVGNSTPV | WYNMVEKGLV | KEPIFSFWLN | RNPKDPEGGE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IVFGGVDPKH | FKGEHTFVPV | THKGYWQFDM | GDLQIAGKPT | GYCAKGCSAI | ADSGTSLLTG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSTVITMINH | AIGAQGIVSR | ECKAVVDQYG | KTMLNSLLAQ | EDPKKVCSQI | GVCAYDGTQS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VSMGIQSVVD | DGTSGLLNQA | MCSACEMAAV | WMESELTQNQ | TQERILAYAA | ELCDHIPTQN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QQSAVDCGRV | SSMPIVTFSI | GGRSFDLTPQ | DYIFKIGEGV | ESQCTSGFTA | MDIAPPRGPL |
| 490 | 500 | ||||
| WILGDIFMGP | YHTVFDYGKG | RVGFAKAA |