AiPD: Autoinhibited Protein Database

Gene name	Napsa (Kdap, Nap)
Protein name	Napsin-A
Names	KDAP-1, Kidney-derived aspartic protease-like protein, KAP
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:16541
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

5-84 (Predicted disordered autoinhibitory region) PR

5-84 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O09043-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs260907547	4	L>P	No	EVA
rs239105084	36	R>S	No	EVA
rs3388907015	42	N>K	No	EVA
rs260190239	47	L>V	No	EVA
rs3388867010	57	G>D	No	EVA
rs3388866979	61	S>A	No	EVA
rs3388907072	81	T>M	No	EVA
rs3388907002	96	N>Y	No	EVA
rs3388904530	99	V>A	No	EVA
rs16785952	127	P>T	No	EVA
rs16785953	134	I>V	No	EVA
rs16785954	151	T>N	No	EVA
rs3388897016	153	G>V	No	EVA
rs16785967	222	G>V	No	EVA
rs16785968	243	T>I	No	EVA
rs3388906511	309	F>L	No	EVA
rs16793446	324	H>R	No	EVA
rs3388907042	355	A>V	No	EVA
rs217999864	375	P>S	No	EVA
rs3388904526	382	R>C	No	EVA
rs31476421	400	S>A	No	EVA
rs3388899211	403	R>W	No	EVA

Type	Name	Position	InterPro Accession
active_site	Aspartic peptidase, active site	88 - 99	IPR001969-1
active_site	Aspartic peptidase, active site	275 - 286	IPR001969-2
domain	Peptidase family A1 domain	72 - 394	IPR033121

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
alveolar lamellar body	A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

Name	Definition
aspartic-type endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
peptidase activity	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

Name	Definition
membrane protein proteolysis	The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
surfactant homeostasis	Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q29078		Pregnancy-associated glycoprotein 1	Sus scrofa (Pig)	PR
P08424	Ren1	Renin	Rattus norvegicus (Rat)	PR
Q9XEC4	APA3	Aspartic proteinase A3	Arabidopsis thaliana (Mouse-ear cress)	PR