Q9W3J8

PR
Gene name
CG10958
Protein name
Dynein regulatory complex protein 1 homolog
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG10958
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-181 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W3J8

Entry ID Method Resolution Chain Position Source
AF-Q9W3J8-F1 Predicted AlphaFoldDB

No variants for Q9W3J8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W3J8

No associated diseases with Q9W3J8

2 regional properties for Q9W3J8

Type Name Position InterPro Accession
domain Dynein regulatory complex protein 1, C-terminal 684 - 741 IPR029440
domain Dynein regulatory complex protein 1/2, N-terminal 119 - 220 IPR039505

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
axonemal dynein complex assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
cilium-dependent cell motility Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
regulation of cilium movement Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32KY1 DRC1 Dynein regulatory complex protein 1 Bos taurus (Bovine) PR
Q96MC2 DRC1 Dynein regulatory complex protein 1 Homo sapiens (Human) PR
Q3USS3 Drc1 Dynein regulatory complex protein 1 Mus musculus (Mouse) PR
Q5XI65 Drc1 Dynein regulatory complex protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDDNEDELEE HQELVSDGSV EEEEEVEPDL GPVDSWESFN DRIDGLIFNE RCDKSVKKLD
70 80 90 100 110 120
ERRLAILNRV RQQFREAPKG VAERCQAQKS PIDQRLELSS ERLNELVRFG KELVTNVRVA
130 140 150 160 170 180
NERRELNRRL FEGAQKNQMH VKLQRESVET MARFENIKAR WTELEETNEP MLLWDQIEEQ
190 200 210 220 230 240
KKRIAEIMAR KDEMISACQA EVDRMNAKYE FDRERQAQDL CCLVERVDHQ VETLKEAYKE
250 260 270 280 290 300
HIQMLRQTIE EERQIFADNA VEKWRTFFDA MNANFDEKAN LVRAREQFYA RQTQQINESQ
310 320 330 340 350 360
EELTKSTRIR LEKECERLEL ELRRTRDNVL MNSEKLDYNY QVLQKRNEEN VIINNQQKRR
370 380 390 400 410 420
VARLHEAIGR TRRGLKNLYN TGKRNIARLS SDIYKLHSNI NDMESKAHQA RLNNREKFDR
430 440 450 460 470 480
IWEINYKELN LLVDRVYHID RIIHEQQLAM PWSSPVPPIP NINKAKKKRN NILEKFDMRI
490 500 510 520 530 540
GRVPKNRVMP NSGVNCKPDI KELPPDSLRL MRNLIRKLSD RGGFLIEERL LKILEPYSEE
550 560 570 580 590 600
EKCLVRIDNI FAALRIRHLR DVKELTKVFM PYTYCPNCQP QGLSPRKCAE VFMKDQKPNR
610 620 630 640 650 660
LQGAAGGQPD EKEHRSTGDT FLPKSEVAAK RCHNHYLVME PALCLHAMNL FTSKMHKKMY
670 680 690 700 710 720
EHEPGSILNA VNLIQITDAE IRNFWRQFSA CFPASKCKLW KTLEHGLNHY VEVLKMRVQY
730 740
DAEVVFLRRQ NEELRHLLQK FTV