Q32KY1

PR
Gene name
DRC1 (CCDC164)
Protein name
Dynein regulatory complex protein 1
Names
Coiled-coil domain-containing protein 164
Species
Bos taurus (Bovine)
KEGG Pathway
bta:509524
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-273 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q32KY1

Entry ID Method Resolution Chain Position Source
AF-Q32KY1-F1 Predicted AlphaFoldDB

69 variants for Q32KY1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs377924664 3 P>L No EVA
rs478617270 15 E>A No EVA
rs461839127 21 P>Q No EVA
rs462499097 27 I>K No EVA
rs439219133 34 E>Q No EVA
rs470637391 38 A>P No EVA
rs453813880 39 R>P No EVA
rs468024684 39 R>W No EVA
rs441392937 40 R>G No EVA
rs472796946 42 R>L No EVA
rs468593463 59 L>I No EVA
rs436257100 81 L>Q No EVA
rs441066440 91 T>N No EVA
rs478743925 97 I>S No EVA
rs441623506 109 R>L No EVA
rs476281080 117 R>C No EVA
rs799978683 183 K>R No EVA
rs450884904 200 I>V No EVA
rs482349543 201 C>G No EVA
rs459035727 204 L>V No EVA
rs479595814 225 I>M No EVA
rs722907661 269 Y>C No EVA
rs466190791 376 L>V No EVA
rs478705972 383 L>I No EVA
rs461826125 383 L>R No EVA
rs443867427 398 F>C No EVA
rs478506042 398 F>L No EVA
rs458386752 399 R>G No EVA
rs458386752 399 R>W No EVA
rs441545465 450 Q>K No EVA
rs472578573 452 K>* No EVA
rs460357251 477 S>P No EVA
rs380118504 493 R>H No EVA
rs473723492 524 Y>S No EVA
rs476048300 530 A>P No EVA
rs437316092 553 Y>N No EVA
rs382586582 576 V>M No EVA
rs438145270 582 E>* No EVA
rs719202874 589 P>A No EVA
rs716038914 596 D>N No EVA
rs463992216 604 F>S No EVA
rs478571120 609 R>G No EVA
rs458041275 609 R>M No EVA
rs441174316 610 K>* No EVA
rs472465571 610 K>R No EVA
rs442101063 611 P>S No EVA
rs456327485 612 R>G No EVA
rs446667194 613 D>A No EVA
rs479248879 614 F>V No EVA
rs461238464 617 P>R No EVA
rs444340128 618 V>E No EVA
rs475423782 619 K>N No EVA
rs448800795 665 Q>E No EVA
rs463412077 672 E>D No EVA
rs480308666 672 E>Q No EVA
rs449815257 674 S>G No EVA
rs482460031 678 R>G No EVA
rs459175526 681 T>R No EVA
rs459696986 683 L>Q No EVA
rs473691974 683 L>V No EVA
rs474270193 686 L>V No EVA
rs437323964 689 Q>* No EVA
rs471539502 689 Q>L No EVA
rs451419773 691 L>P No EVA
rs434600523 692 D>G No EVA
rs465912202 693 T>A No EVA
rs474637274 698 E>G No EVA
rs454608134 701 V>A No EVA
rs1114295998 708 R>W No EVA

No associated diseases with Q32KY1

3 regional properties for Q32KY1

Type Name Position InterPro Accession
domain Magnesium chelatase ChlI-like, catalytic domain 191 - 261 IPR000523
domain AAA+ ATPase domain 102 - 284 IPR003593
domain ChlI/MoxR, AAA lid domain 341 - 398 IPR041628

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, cilium axoneme
  • Cytoplasm, cytoskeleton, flagellum axoneme
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
axonemal dynein complex assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
cilium-dependent cell motility Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
regulation of cilium movement Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9W3J8 CG10958 Dynein regulatory complex protein 1 homolog Drosophila melanogaster (Fruit fly) PR
Q96MC2 DRC1 Dynein regulatory complex protein 1 Homo sapiens (Human) PR
Q3USS3 Drc1 Dynein regulatory complex protein 1 Mus musculus (Mouse) PR
Q5XI65 Drc1 Dynein regulatory complex protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MNPPGSLGVL EEKEEEHLAP PILGPSIHSD NPQERIQARR LRIAARLEAR RREALGEYLD
70 80 90 100 110 120
GKKESEEDQS KSYKQKEESR LKLAKLLLCG TELVTNIQVA ADIREIHRRV EEEEIKRQRL
130 140 150 160 170 180
EKLENEVKTS QDKFDEITVK WEEGKQRRIP QELWEMLNAQ QVHCAGLIED KNKLISELQQ
190 200 210 220 230 240
ELKMKDDQYV KDLKKQSDDI CLLLERMEEQ VKNVMKTFRQ ELQNIEKAFE VERQELLTSN
250 260 270 280 290 300
KKKWERALQA HNAKELEYLM NRIKKVEDYE KQLNKQRIWD CEEYNTIKIK LEQDVQILEQ
310 320 330 340 350 360
QLQQMKATYQ LNQEKLEYNF QVLKKRDEES TVIKSQQKRK INRLHDVLNN LRSKYNKQVK
370 380 390 400 410 420
QFQEENQSLT SDYKRLVLQF KELQKAMRHF ALIDDKRFRE IWLMNEEEAK DLINRAFDVD
430 440 450 460 470 480
RIISTHHLGL PWMAPDFWFL KNVGPISQQQ QKSATQILEE VLMEAEKEGA DEDSSESETY
490 500 510 520 530 540
LDLPKQVSAR TTRKILMLLC DESGFLIESK LLSLLLPLEK NECYLLRLDA VFSALGIENE
550 560 570 580 590 600
DDLYKLVNFF LKYQTHHSPS SQEPLDLRAE KERSLVDGKS QEKEPPPSPK LIHPNDVLKI
610 620 630 640 650 660
LEAFVMSLRK PRDFWVPVKL LKAVRDDSKD SEYWEALTTV IPATTLNLWD ALYTALEKYH
670 680 690 700 710
LVLTQRAELL IENSSLERQN TELQQLLQQY LDTKINSELQ VPPTQVFRVP TK