AiPD: Autoinhibited Protein Database

Gene name	Drc1 (Ccdc164, Gm1060)
Protein name	Dynein regulatory complex protein 1
Names	Coiled-coil domain-containing protein 164
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:381738
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-169 (Predicted disordered autoinhibitory region) PR

1-169 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3USS3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs235224897	20	T>P	No	EVA
rs226753713	69	Q>H	No	EVA
rs3388751548	106	I>L	No	EVA
rs232008660	203	I>M	No	EVA
rs3388740297	211	V>E	No	EVA
rs232801021	212	K>R	No	EVA
rs262947118	220	Q>H	No	EVA
rs3388750469	268	D>N	No	EVA
rs3395038395	309	Y>F	No	EVA
rs3388740349	318	Y>N	No	EVA
rs3388723539	322	V>I	No	EVA
rs3388746520	326	R>I	No	EVA
rs3388743093	341	L>M	No	EVA
rs3388751005	350	N>I	No	EVA
rs3388752605	350	N>K	No	EVA
rs3388747905	351	L>P	No	EVA
rs3388723563	382	D>G	No	EVA
rs255468872	392	I>V	No	EVA
rs3388747874	399	R>L	No	EVA
rs3388742711	431	P>L	No	EVA
rs3388723572	434	M>K	No	EVA
rs3395163332	452	K>V	No	EVA
rs3388746885	478	E>K	No	EVA
rs3388752626	490	K>T	No	EVA
rs229532735	495	V>I	No	EVA
rs3388756529	507	I>L	No	EVA
rs3388742694	521	S>I	No	EVA
rs3388747941	537	I>N	No	EVA
rs247779105	568	H>Q	No	EVA
rs216396886	579	A>V	No	EVA
rs248827814	614	A>T	No	EVA
rs236390397	655	A>V	No	EVA
rs254350891	661	L>V	No	EVA
rs3388751010	680	A>V	No	EVA
rs221426303	685	F>S	No	EVA
rs229236048	706	E>Q	No	EVA
rs3388743073	735	K>N	No	EVA
rs3388743100	742	I>N	No	EVA

Type	Name	Position	InterPro Accession
domain	Dynein regulatory complex protein 1, C-terminal	673 - 732	IPR029440
domain	Dynein regulatory complex protein 1/2, N-terminal	99 - 200	IPR039505

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
axonemal dynein complex	A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
axoneme	The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
motile cilium	A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.

Name	Definition
No GO annotations for molecular function

Name	Definition
axonemal dynein complex assembly	The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
cilium-dependent cell motility	Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
determination of left/right symmetry	The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
regulation of cilium movement	Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q32KY1	DRC1	Dynein regulatory complex protein 1	Bos taurus (Bovine)	PR
Q9W3J8	CG10958	Dynein regulatory complex protein 1 homolog	Drosophila melanogaster (Fruit fly)	PR
Q96MC2	DRC1	Dynein regulatory complex protein 1	Homo sapiens (Human)	PR
Q5XI65	Drc1	Dynein regulatory complex protein 1	Rattus norvegicus (Rat)	PR