Q9W1X7

PR
Gene name
MED23 (Trap150, CG3695)
Protein name
Mediator of RNA polymerase II transcription subunit 23
Names
Mediator complex subunit 23, dSUR2, dTRAP150
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG3695
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1286-1439 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W1X7

Entry ID Method Resolution Chain Position Source
AF-Q9W1X7-F1 Predicted AlphaFoldDB

No variants for Q9W1X7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W1X7

No associated diseases with Q9W1X7

No regional properties for Q9W1X7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9W1X7

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

1 GO annotations of molecular function

Name Definition
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

2 GO annotations of biological process

Name Definition
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9ULK4 MED23 Mediator of RNA polymerase II transcription subunit 23 Homo sapiens (Human) PR
Q80YQ2 Med23 Mediator of RNA polymerase II transcription subunit 23 Mus musculus (Mouse) PR
Q5EB59 Med23 Mediator of RNA polymerase II transcription subunit 23 Rattus norvegicus (Rat) PR
Q10669 sur-2 Mediator of RNA polymerase II transcription subunit 23 Caenorhabditis elegans PR
10 20 30 40 50 60
METQVIDTVN EFLKVDSLDE AFVSVIVFKP NTEQERATRF ANDLVTAFGN VAQENREQVL
70 80 90 100 110 120
RLYLLRAAGA SGYHIKVLMA ALVKLVDAHV ITARMLCDKV LMCEKLDFEH RTFWIESFRL
130 140 150 160 170 180
IKRVIVQVDY KGVREIMKVC RDKAQWFPLN VNVTYMPQLL AVEDILRFIF DRNNCLLPAY
190 200 210 220 230 240
FIANEIMRPF PYHWKLNRLM TDFVEEFRTT AQMVSIIGHA SMLPIVEHFG YADHMMNSWR
250 260 270 280 290 300
LDHNTLKFNF KGSLPYEPEL LEEQKPLLRY VLEQPYSREM VSQMLNLQKH QKQRYNALEE
310 320 330 340 350 360
QLVNLIVQAM EMTEANDATA GSGFNSSDEQ ITPYEWMWLH LSSQLIYFVL FQFVSFMHIV
370 380 390 400 410 420
LALHEKLSKL ELRKGRDQLM WILLQFISGS IQKNPITNFL PVFRLFDLLY PELEPLKLPD
430 440 450 460 470 480
INKSSMVRHM APICVWIHLM KKARVENMNI TRPLPIALKN HYDFLQHLVT ANTMMNMTLG
490 500 510 520 530 540
NDFRIILICN AYSTNQEYFG RPMGLLLDAL NGTSKSPNGG QIPAVTFSVT VLDSLTVHSK
550 560 570 580 590 600
MSLIHSFVTQ MLKQAQSKGQ VPAAALLETY ARLLVYTEIE SLGIKGFLSQ LMPTVFKNHA
610 620 630 640 650 660
WAMLHTLMEM FSYRLHHVPT HYRVQLLSLL HSLSSVPQTN KMQLNLCFES TALRLITSIG
670 680 690 700 710 720
SAEFQPQFSR YFNDKSPGAV ASNESEELNR VLILTLARSM HVHGGGDEMQ GWCKDFLSNI
730 740 750 760 770 780
IQHTPHSWPM HSLACFPPAL NEYFTQNNQP PENKQQLKKA VEEEYRTWTS MTNENDIIAH
790 800 810 820 830 840
FLRPTTNPLF LCLLFKIIWE TENISPVAYK ILEGISARAL STHLRKFCDY LVAEVASSSD
850 860 870 880 890 900
GRDFIHKCVD TINNMIWKFN VVTIDRVVLC LALRTHEGNE AQVCFLIIQL LLLKASELRN
910 920 930 940 950 960
RVQEFCKDNN PDHWKQSNWQ DKHLSFHQKY PEKFALDESA SQIPLPVYFS NVCLRFLPVL
970 980 990 1000 1010 1020
DVVVHRFIEL TITNVHQILG FILDHLSILY KFHDRPITYL YNTLHYYERI LRDRPALKKK
1030 1040 1050 1060 1070 1080
LVGAITSAFS EIRPPNWSVS EPYKVYLQSQ DSLWTPELSY YMSLIRRLAD TISGKNVFYS
1090 1100 1110 1120 1130 1140
TDWRFNEFPN APTHALYVTC VELLGLPVAP PLVASNLIDV IVSGYAVIPQ KDIHSYINAV
1150 1160 1170 1180 1190 1200
GIVLAALPEP YWSGIYDRLQ DMLNTPNMLN WTYRFNAFEL FNFKTVREAM LEKTYAVVLA
1210 1220 1230 1240 1250 1260
VAHSVFHHMG AFKLAAMTRY LKEKLKPCVR TEQQLLYLCH VFGPFLQRIE LEKPNAVAGI
1270 1280 1290 1300 1310 1320
AVLLYEILEI VDKHHGPKPL QYMDQICDFL YHIKYIHVGN IIKNESEAII KRLRPLLQMR
1330 1340 1350 1360 1370 1380
LRFITHLNLE DIHTEKINDN TSNNAITSQT QSPMQTQHQQ QPQQPHQQQQ QQQQQQQQQQ
1390 1400 1410 1420 1430
QQQQQQQQMQ QQQINAVQTT SVPLGSGGNL QQQQQINQQQ QMYMQHMQQH QHMQNMRHN