Q5EB59

PR
Gene name
Med23 (Crsp3)
Protein name
Mediator of RNA polymerase II transcription subunit 23
Names
Cofactor required for Sp1 transcriptional activation subunit 3, CRSP complex subunit 3, Mediator complex subunit 23
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

714-788 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5EB59

Entry ID Method Resolution Chain Position Source
AF-Q5EB59-F1 Predicted AlphaFoldDB

No variants for Q5EB59

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5EB59

No associated diseases with Q5EB59

3 regional properties for Q5EB59

Type Name Position InterPro Accession
conserved_site Ribosomal protein S2, conserved site 15 - 26 IPR018130-1
conserved_site Ribosomal protein S2, conserved site 119 - 143 IPR018130-2
domain 40S ribosomal protein SA, C-terminal domain 202 - 247 IPR032281

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
core mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of T cell extravasation Any process that activates or increases the frequency, rate or extent of T cell extravasation.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9W1X7 MED23 Mediator of RNA polymerase II transcription subunit 23 Drosophila melanogaster (Fruit fly) PR
Q9ULK4 MED23 Mediator of RNA polymerase II transcription subunit 23 Homo sapiens (Human) PR
Q80YQ2 Med23 Mediator of RNA polymerase II transcription subunit 23 Mus musculus (Mouse) PR
Q10669 sur-2 Mediator of RNA polymerase II transcription subunit 23 Caenorhabditis elegans PR
10 20 30 40 50 60
METQLQSIFE EVVKTEIIEE AFPGMFMDTP EDEKTKLISC LAAFRQFWNG LSQESHEQCV
70 80 90 100 110 120
QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRMVCES LINSDTLEWE RTQLWALTFK
130 140 150 160 170 180
LVRKIIGGVD YKGVRDLLKV ILEKILTIPN TVSSAVVQQL LAAREVIAYI LERNACLLPA
190 200 210 220 230 240
YFAVTEIRKL YPEGKLPHWL LGNLVSDFVD TFRPTARINS ICGRCSLLPV VNNSGAICNS
250 260 270 280 290 300
WKLDPATLRF PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQHKQRCPVL
310 320 330 340 350 360
EDQLVDLVVY AMERSETEEK FDDGGTSQLL WQHLSSQLIF FVLFQFASFP HMVLSLHQKL
370 380 390 400 410 420
AGRGLIKGRD HLMWVLLQFI SGSIQKNALA DFLPVMKLFD LLYPEKECIP VPDINKPQST
430 440 450 460 470 480
HAFAMTCIWI HLNRKAQNDN SKLQIPIPHS LKLHHEFLQQ SLRNKSLQMN DYKIALLCNA
490 500 510 520 530 540
YSTNSECFTL PMGALVETIY GNGIMRVPLP GTSCLASASV TPLPMNLLDS LTVHAKMSLI
550 560 570 580 590 600
HSIATRVIKL AHTKSSVALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI
610 620 630 640 650 660
LHTLLEMFSH RMHHIQPHYR VQLLSHLHTL AAVAQTNQNQ LHLCVESTAL RLITALGSSE
670 680 690 700 710 720
VQPQFTRFLN DPKTVLSAES EELNRALILT LARATHVTDF FTGSDSIQGT WCKDILQTIM
730 740 750 760 770 780
TFTPHNWASH TLSCFPAPLQ AFFKQNNVPQ ESRFNLKKNV EEEYRKWKSM TDENEIITQF
790 800 810 820 830 840
SMQGFPPLFL CLLWKMLLET DHISQIGYKV LERIGARALV AHVRTFADFL VYEFSTSAGG
850 860 870 880 890 900
QQLNKCIEIL NDMVWKYNIV TLDRLILCLA MRSHEGNEAQ VCYFIIQLLL LKPNDFRNRV
910 920 930 940 950 960
SDFVKENSPE HWLQSDWHTK HMSYHKKYPE KLYFEGLAEQ VDPPVPIQSP YLPIYFGNVC
970 980 990 1000 1010 1020
LRFLPVFDIV IHRFLELLPV SKSLETLLDH LGGLYKFHDR PVTYLYNTLH YYEMCLRNRD
1030 1040 1050 1060 1070 1080
HLKRKLVHAI IGSLKDNRPQ GWCLSDTYLK HAMNAREDNP WVPEDSYYCK LIGRLVDTMA
1090 1100 1110 1120 1130 1140
GKSPGPFPNC DWRFNEFPNP AAHALHVTCV ELMALAVPGK DVGNALLNVV LKSQPLVPRE
1150 1160 1170 1180 1190 1200
NITAWMNAIG LIITALPEPY WIVLHDRIVS VISSSSLTSE TEWVGYPFRL FDFTACHQSY
1210 1220 1230 1240 1250 1260
SEMSCSYTLA LAHAVWHHSS IGQLSLIPKF LTEVLLPVVK TEFQLLYVYH LVGPFLQRFQ
1270 1280 1290 1300 1310 1320
QERTRCMIEI GVAFYDMLLN VDQCSTHLNY MDPICDFLYH MKYMFTGDSV KEQVEKIICN
1330 1340 1350 1360
LKPALKLRLR FITHISKMEP AVPPQALSSG SPAPQANQVP TALPVTQ