Q10669

PR
Gene name
sur-2 (mdt-23, F39B2.4)
Protein name
Mediator of RNA polymerase II transcription subunit 23
Names
Mediator complex subunit 23, Mediator complex subunit sur-2
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F39B2.4
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1337-1587 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10669

Entry ID Method Resolution Chain Position Source
AF-Q10669-F1 Predicted AlphaFoldDB

No variants for Q10669

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10669

No associated diseases with Q10669

No regional properties for Q10669

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q10669

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9W1X7 MED23 Mediator of RNA polymerase II transcription subunit 23 Drosophila melanogaster (Fruit fly) PR
Q9ULK4 MED23 Mediator of RNA polymerase II transcription subunit 23 Homo sapiens (Human) PR
Q80YQ2 Med23 Mediator of RNA polymerase II transcription subunit 23 Mus musculus (Mouse) PR
Q5EB59 Med23 Mediator of RNA polymerase II transcription subunit 23 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MTDKPGSAED TIEMDDTCSP QFVQEVNRIK SQIKSLVEEN HTRKFFRPLT SNIGDETAIL
70 80 90 100 110 120
RIQFNNMMSK MEEKEKQSLV KELIKMVHHV AEKNSPDRVF VGTNYERVVD QLLRYAHQKG
130 140 150 160 170 180
AISTNLCAEG LIMTSDFRLC SRICQEKWKF INDCIPKIDY KGIRNILRYI LESQLRRLPY
190 200 210 220 230 240
SLSPEQVNEI RIVENVILHI VDRDSNLMPP LITLSEIMRG MPKQALMLPR LTEKLASLSV
250 260 270 280 290 300
HFRPIADLSH VCGRGFVYPI PLHPSFYPLT SCWEEHGLNA SNTIVQPHHT LPYRPEHTST
310 320 330 340 350 360
YLYTLYMILR QPLGKDSLHP PSKTKTKTNW EMLISVMICE SMAEAESLPE TEPIPRYQWD
370 380 390 400 410 420
NIVNIVIYGI TQHLLVPKTF FNVLKNLIKR CKYTRARDEV MWIVFQVVGS LSNLTRLDDA
430 440 450 460 470 480
VTEIVELYNE LFDGDVVWMG ASDHPALFAR FLAAAGTWMI LEKDFADKMP PANETIKSHI
490 500 510 520 530 540
KFIQDGVDNF DSSNTAMLAV LSNIYRTDTK MGKLIVPTLQ QMLESIDDTK SLFELSYKRM
550 560 570 580 590 600
AVNCFSAFPV EFMEALTFRS KKTLLIQCFQ PLRSFSTVRL PSPAVFETVA KICESEDYEM
610 620 630 640 650 660
AVKDMEHLAQ RSLHVATAAD RSSGEHQNVQ AKDQCYFLFD FLVYRLPHLH AYSKYSSTVN
670 680 690 700 710 720
ALSYFTQHIP NNPQNHQIYR LMEQFLMRRW CWAGFHGCIT AHTQMFGTSY KDNTMMRHMA
730 740 750 760 770 780
YPKTFSVPDQ YPFAINPEIF KMAIYSFLRA VKITAQDIAI EKTMFPTIIN GFGWPEKSTS
790 800 810 820 830 840
YFPKWALDAI KASDTSNAVN TEEILSDVRN TARMHTSLTP NQFVIRYGED RDPATSHCML
850 860 870 880 890 900
AVLFHFAYNS VDSTYNITSE FYEVMEKKTP KEIVVMGNYL VDYIIADAKT QDCNEKTFKN
910 920 930 940 950 960
IAKAAALLVF QFQVLRADRL LLSLIMHPAT DEDALICIQI ANEFILTPEF QERIRWYHQN
970 980 990 1000 1010 1020
VPKKDHFPTE YIKAIVKYHD AFPEFEACEL VRSYDSSSNV HMPTYYGCLI ERLLPIMDQY
1030 1040 1050 1060 1070 1080
LHVALEQQGY KLNPQILQSV SMLYKFHAMP IHFMYSVLFT SHGLMSGPDA KSFVLAFATQ
1090 1100 1110 1120 1130 1140
IEECHLTEAF EKFNHQKSSR EQLIMELIDR MSASLDFILT PPPFVAKDWK IAELSPGAQT
1150 1160 1170 1180 1190 1200
LYLACIELMA SPHSPETLVA AMINVMQMKP HARPFNIVNL TALLLTALPA AYSNALHDEF
1210 1220 1230 1240 1250 1260
VAVFVNGETA NLKFEEIVFD NYEESLLLNL PNRARTINVI SQQYWLHCSL SLLNFFSHEY
1270 1280 1290 1300 1310 1320
VPRILEHVKT EKDLWYTLRL VMPYLRRYYE NWDTAKQMRS QRENFGPLHI VKLVFQKLGS
1330 1340 1350 1360 1370 1380
MAEEGVEIVY EQHLCDLFYN CKYFFAGDFL RNTAITEFAK LPEKMRDRLK FYVSQSEPTA
1390 1400 1410 1420 1430 1440
EQETPPEKEK SPEKEKEQEQ EQHVKAHQPL ESTPSVSSLP QMQHHLQQAP LLPSHQMMPP
1450 1460 1470 1480 1490 1500
PQQHSSSLQH HLQHHTSTHQ MMDTSQHQTI QQQSNHPTQQ QLQHQIPNMS MHQQMGPQYP
1510 1520 1530 1540 1550 1560
GAVFHHPSGP VGHVPMQYGM GHHMQQHPHL PHHQQMPAPM HTMNPMMQNM TPQQQYLYMQ
1570 1580
QLQQHQQHQQ YMQQQQQHHH QHQQQPH