Q9VU87

PR
Gene name
Vps36 (CG10711)
Protein name
Vacuolar protein-sorting-associated protein 36
Names
ESCRT-II complex subunit VPS36
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG10711
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-255 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VU87

Entry ID Method Resolution Chain Position Source
AF-Q9VU87-F1 Predicted AlphaFoldDB

No variants for Q9VU87

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VU87

No associated diseases with Q9VU87

1 regional properties for Q9VU87

Type Name Position InterPro Accession
domain Vacuolar protein sorting protein 36, GLUE domain 1 - 144 IPR021648

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endosome A vacuole to which materials ingested by endocytosis are delivered.
ESCRT II complex An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
late endosome membrane The lipid bilayer surrounding a late endosome.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

3 GO annotations of molecular function

Name Definition
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

6 GO annotations of biological process

Name Definition
bicoid mRNA localization Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PK00 VPS36 Vacuolar protein-sorting-associated protein 36 Bos taurus (Bovine) PR
Q86VN1 VPS36 Vacuolar protein-sorting-associated protein 36 Homo sapiens (Human) PR
Q7ZVK4 vps36 Vacuolar protein-sorting-associated protein 36 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MNRFAYVEAR LSPNESFVSR DNRVKIYDGD QKTDFEDGEV VLTTHRLFWG RPGEIARAAV
70 80 90 100 110 120
TLCLPLSYVI SVSEETTASN FFGRKTRIIM HLHPPTSDKG PGPLDTSRAT HIKLSGKNGL
130 140 150 160 170 180
SVEFHSALRE TLNARVWEIL LTSEIIINGV ASSPTLEPAN DRLARIQKRT GIGGIERHLE
190 200 210 220 230 240
AKAKATDENI ALAFQDLSVL MAMAKDMVGV SKTISSKIRK QKGEISDDET VRFKSYLMSL
250 260 270 280 290 300
GIDDPVTRDN FTSNSAYFSS LARQICEMLL DPIEEQGGMM SLADVYCRVN RARGLELLSP
310 320 330 340 350 360
EDLLHACEQL SGPIRLRSFP SGARVLQLES HDDALIAVDT LEKVEAAESL AVEELAKQLG
370 380 390
ISLLLAKERL LVAERLGKVC RDESVEGLRF YPNLLLGRD