Q7ZVK4

PR
Gene name
vps36 (zgc:55965)
Protein name
Vacuolar protein-sorting-associated protein 36
Names
ESCRT-II complex subunit VPS36
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:335810
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

43-240 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZVK4

Entry ID Method Resolution Chain Position Source
AF-Q7ZVK4-F1 Predicted AlphaFoldDB

No variants for Q7ZVK4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZVK4

No associated diseases with Q7ZVK4

1 regional properties for Q7ZVK4

Type Name Position InterPro Accession
domain Vacuolar protein sorting protein 36, GLUE domain 1 - 138 IPR021648

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Endosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endosome A vacuole to which materials ingested by endocytosis are delivered.
ESCRT II complex An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
late endosome membrane The lipid bilayer surrounding a late endosome.

2 GO annotations of molecular function

Name Definition
phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

2 GO annotations of biological process

Name Definition
anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PK00 VPS36 Vacuolar protein-sorting-associated protein 36 Bos taurus (Bovine) PR
Q9VU87 Vps36 Vacuolar protein-sorting-associated protein 36 Drosophila melanogaster (Fruit fly) PR
Q86VN1 VPS36 Vacuolar protein-sorting-associated protein 36 Homo sapiens (Human) PR
10 20 30 40 50 60
MDRFMWTNGL LEMNETLVIQ QRGVRLYDGE DKAKLDVGGV VLSTHRLLWR DQKNHECCIC
70 80 90 100 110 120
IPLSQVIFFE EQAAGIGKSA KIVIHLHPAP ENKEPGPYQH SKYSYIKLSF KEHGQIEFYR
130 140 150 160 170 180
RLTEEMTQKR WENTPVSQPI PTGTGPKAGR TRAVGIVGIE RKLEEKRKET DKNISEAFED
190 200 210 220 230 240
LSKLMEKAKE MVELSRSIAN KIKDKQGDIT EDETIRFKSY LLSMGIANPV TRETHGSGTQ
250 260 270 280 290 300
YHIQLAKQLG DMLQAPLEER GGMMALTEVY CLVNRARGME LLSPEDLVNA CKIFESLKLP
310 320 330 340 350 360
LRLRVFDSGV MVVQLQSHSE EEMIASALDN VSDKGSLTAE EFAKLLGLSV LLAKERLLLA
370 380
EKMGHLCRDD SVEGLRFYPN LF