A5PK00

PR
Gene name
VPS36
Protein name
Vacuolar protein-sorting-associated protein 36
Names
ESCRT-II complex subunit VPS36
Species
Bos taurus (Bovine)
KEGG Pathway
bta:511223
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

50-239 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5PK00

Entry ID Method Resolution Chain Position Source
AF-A5PK00-F1 Predicted AlphaFoldDB

No variants for A5PK00

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5PK00

No associated diseases with A5PK00

1 regional properties for A5PK00

Type Name Position InterPro Accession
domain Vacuolar protein sorting protein 36, GLUE domain 1 - 138 IPR021648

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Endosome
  • Late endosome
  • Membrane
  • Nucleus
  • Colocalizes with ubiquitinated proteins on late endosomes
  • Recruited to the endosome membrane to participate in vesicle formation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endosome A vacuole to which materials ingested by endocytosis are delivered.
ESCRT II complex An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
late endosome membrane The lipid bilayer surrounding a late endosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

1 GO annotations of biological process

Name Definition
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VU87 Vps36 Vacuolar protein-sorting-associated protein 36 Drosophila melanogaster (Fruit fly) PR
Q86VN1 VPS36 Vacuolar protein-sorting-associated protein 36 Homo sapiens (Human) PR
Q7ZVK4 vps36 Vacuolar protein-sorting-associated protein 36 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDRFVWTSGL LEINETLVIQ QRGVRIYDGE EKIKFDPGTL LLSTHRLIWR DQKNHECCMA
70 80 90 100 110 120
IPLSQIVFIE EQAAGIGKSA KIVVHLHPAA SNKEPGPFQS SKNSYIKLSF KEHGQIEFYR
130 140 150 160 170 180
RLSEEMTQRR WENMPVPQSL QTNRGPQPGR IRAVGIVGIE RKLEEKRKET DKNISEAFED
190 200 210 220 230 240
LSKLMVKAKE MVELSKSIAN KIKDKQGDIT EDETIRFKSY LLSMGIANPV TRETYGSGTQ
250 260 270 280 290 300
YHMQLAKQLA GILQAPLEER GGIMSLTEVY CLVNRARGME LLSPEDLVNA CKMLEALKLP
310 320 330 340 350 360
LRLRVFDSGV MVIELQSHKE EEMVASALET VSEKGSLTSE EFAKLMGMSV LLAKERLLLA
370 380
EKMGHLCRDD SVEGLRFYPN LFMTQS