AiPD: Autoinhibited Protein Database

Q9ULX3

Gene name	NOB1 (ART4, NOB1P, PSMD8BP1, MSTP158)
Protein name	RNA-binding protein NOB1
Names	Phosphorylation regulatory protein HP-10, Protein ART-4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:28987
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

74-253 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

74-253 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

14 structures for Q9ULX3

Entry ID	Method	Resolution	Chain	Position	Source
6G18	EM	360 A	y	1-412	PDB
6G4S	EM	400 A	y	1-412	PDB
6G51	EM	410 A	y	1-412	PDB
6G53	EM	450 A	y	1-412	PDB
6G5I	EM	350 A	y	1-412	PDB
6ZUO	EM	310 A	y	1-412	PDB
6ZXD	EM	320 A	y	1-412	PDB
6ZXE	EM	300 A	y	1-412	PDB
6ZXF	EM	370 A	y	1-412	PDB
7WTW	EM	320 A	y	1-412	PDB
7WTX	EM	310 A	y	1-412	PDB
7WTZ	EM	300 A	y	1-412	PDB
7WU0	EM	330 A	y	1-412	PDB
AF-Q9ULX3-F1	Predicted				AlphaFoldDB

432 variants for Q9ULX3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA396503212 rs1221169615	2	A>D		No	ClinGen TOPMed gnomAD
CA396503210 rs1221169615	2	A>V		No	ClinGen TOPMed gnomAD
CA396503209 rs1567645274	3	P>A		No	ClinGen Ensembl
rs779746015 CA8136886	3	P>L		No	ClinGen ExAC gnomAD
CA396503200 rs1303417754	4	V>A		No	ClinGen TOPMed gnomAD
CA396503199 rs1303417754	4	V>G		No	ClinGen TOPMed gnomAD
rs1370315314 CA396503194	5	E>A		No	ClinGen TOPMed gnomAD
CA396503196 rs1370315314	5	E>G		No	ClinGen TOPMed gnomAD
CA283396908 rs573473324	5	E>K		No	ClinGen 1000Genomes
CA8136885 rs371086568	6	H>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136883 rs148444486 CA396503185	6	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136884 rs371086568	6	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA283396895 rs1019734193	7	V>L		No	ClinGen TOPMed
CA396503157 rs763123715	9	A>E		No	ClinGen ExAC TOPMed gnomAD
CA8136882 rs763123715	9	A>V		No	ClinGen ExAC TOPMed gnomAD
rs765530372 CA396503132	11	A>G		No	ClinGen ExAC gnomAD
rs765530372 CA8136880	11	A>V		No	ClinGen ExAC gnomAD
rs561570866 CA8136879	12	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1230946335 CA396503115	13	A>T		No	ClinGen TOPMed gnomAD
rs1206442278 CA396503107	13	A>V		No	ClinGen TOPMed gnomAD
rs777010192 CA283396862	14	F>S		No	ClinGen ExAC TOPMed gnomAD
CA396503102 rs1277862380	14	F>V		No	ClinGen gnomAD
rs777010192 CA8136878	14	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs1227385239 CA396503082	16	R>W		No	ClinGen gnomAD
CA396503065 rs1278081687	17	H>L		No	ClinGen TOPMed gnomAD
CA396503071 rs1370818453	17	H>Y		No	ClinGen gnomAD
rs1444828755 CA396503059	18	A>T		No	ClinGen gnomAD
CA283396843 rs868569248	18	A>V		No	ClinGen gnomAD
CA283396836 rs995350853	19	A>V		No	ClinGen Ensembl
rs149323142 CA396503023	21	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136875 rs149323142	21	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA283396597 rs775032781	22	D>E		No	ClinGen TOPMed
CA396502930 rs1359930148	24	G>R		No	ClinGen gnomAD
CA8136855 rs773802175	25	K>N		No	ClinGen ExAC gnomAD
CA8136854 rs768064932	30	I>V		No	ClinGen ExAC gnomAD
CA8136852 rs534370822	31	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs534370822 CA396502837	31	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769562492 CA8136853	31	R>W		No	ClinGen ExAC gnomAD
rs745638211 CA8136850	34	V>F		No	ClinGen ExAC TOPMed gnomAD
CA396502795 rs1421005354	35	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1421005354 CA396502796	35	T>P		No	ClinGen TOPMed gnomAD
rs1487915709 CA396502771	37	I>L		No	ClinGen gnomAD
rs1382529224 CA396502765	37	I>T		No	ClinGen TOPMed
rs866099272 CA283396577	38	R>Q		No	ClinGen Ensembl
CA396502727 rs1220656545	40	K>N		No	ClinGen TOPMed gnomAD
CA8136848 rs548876427	40	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA283396567 rs1000859047	41	A>G		No	ClinGen TOPMed gnomAD
COSM704350 CA396502705 rs1281112665	42	T>I	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs746961475 CA8136846	43	R>L		No	ClinGen ExAC gnomAD
rs757218713 CA8136847	43	R>S		No	ClinGen ExAC TOPMed gnomAD
rs755017627 CA8136844	45	R>W		No	ClinGen ExAC gnomAD
CA396502667 rs1597619266	46	L>V		No	ClinGen Ensembl
rs754016683 CA8136843	47	A>T		No	ClinGen ExAC TOPMed gnomAD
CA283396516 rs1014453392	47	A>V		No	ClinGen TOPMed
CA396502652 rs1246576366	48	V>L		No	ClinGen TOPMed
rs1425224816 CA396502625	51	Y>C		No	ClinGen TOPMed
CA396502614 rs1297445413	52	E>A		No	ClinGen gnomAD
CA396502595 rs1470980097	54	R>Q		No	ClinGen TOPMed gnomAD
CA283396489 rs376699080	54	R>W		No	ClinGen gnomAD
rs1597619243 CA396502590	55	F>V		No	ClinGen Ensembl
CA8136838 rs200769662	56	K>R		No	ClinGen ExAC TOPMed gnomAD
CA396502563 rs1426647057	57	E>G		No	ClinGen gnomAD
CA396502547 rs1386262014	59	L>V		No	ClinGen TOPMed
rs745661273 CA283396476	60	P>L		No	ClinGen gnomAD
CA396502533 rs745661273	60	P>R		No	ClinGen gnomAD
CA8136837 rs774845473	60	P>S		No	ClinGen ExAC gnomAD
CA8136836 rs377181676	62	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136835 rs762361319	63	V>L		No	ClinGen ExAC TOPMed gnomAD
rs769303366 CA8136833	64	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8136834 rs373593608	64	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1247780048 CA396502009	68	E>D		No	ClinGen TOPMed
rs144970081 CA8136810	71	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA283394646 rs372860357	72	K>E		No	ClinGen ESP TOPMed
CA283394631 rs888946950	73	T>I		No	ClinGen TOPMed
rs888946950 CA396501975	73	T>R		No	ClinGen TOPMed
CA396501966 rs1567644537	74	G>A		No	ClinGen Ensembl
CA8136809 rs773108247	74	G>R		No	ClinGen ExAC gnomAD
rs1597618373 CA396501962	75	D>N		No	ClinGen Ensembl
TCGA novel	75	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8136806 rs779940271	76	Y>S		No	ClinGen ExAC gnomAD
rs1261175053 CA396501925	77	P>L		No	ClinGen gnomAD
CA283394581 rs370088586	77	P>S		No	ClinGen ESP TOPMed gnomAD
rs769869014 CA8136805	78	S>N		No	ClinGen ExAC TOPMed gnomAD
rs897923990 CA283394567	79	L>F		No	ClinGen gnomAD
rs781381974 CA8136803	82	T>M		No	ClinGen ExAC TOPMed gnomAD
rs868114755 CA283394539	85	Q>E		No	ClinGen TOPMed
TCGA novel	87	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1246679557 CA396501767	88	A>T		No	ClinGen gnomAD
COSM972942 rs751843082 CA8136801	88	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1383552271 CA396501738	89	L>P		No	ClinGen gnomAD
rs1299121919 CA396501713	90	T>I		No	ClinGen gnomAD
CA396501703 rs1165984120	91	Y>C		No	ClinGen gnomAD
CA8136798 rs753258652	91	Y>N		No	ClinGen ExAC gnomAD
rs1372576424 CA396501648	95	A>T		No	ClinGen TOPMed gnomAD
CA283394489 rs768744592	96	E>G		No	ClinGen TOPMed
rs753455172 CA396501611	98	V>I		No	ClinGen ExAC TOPMed gnomAD
rs753455172 CA8136795	98	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8136794 rs766107921	100	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	101	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8136792 rs772834575	102	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8136789 rs774343651	107	P>R		No	ClinGen ExAC TOPMed gnomAD
CA8136790 rs761590982	107	P>S		No	ClinGen ExAC TOPMed gnomAD
CA283394444 rs761590982	107	P>T		No	ClinGen ExAC TOPMed gnomAD
rs768642056 CA8136788	108	Q>*		No	ClinGen ExAC gnomAD
CA396501462 rs768642056	108	Q>E		No	ClinGen ExAC gnomAD
rs201082498 CA283394414	108	Q>R		No	ClinGen 1000Genomes
TCGA novel	109	K>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8136766 rs771007827	114	S>L		No	ClinGen ExAC
rs773476588 CA8136765	115	S>*		No	ClinGen ExAC TOPMed gnomAD
CA8136764 rs773476588	115	S>L		No	ClinGen ExAC TOPMed gnomAD
CA8136762 rs367786741	116	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136761 rs779460417	117	Q>E		No	ClinGen ExAC gnomAD
TCGA novel	120	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1431730457 CA396501082	122	P>S		No	ClinGen gnomAD
CA283392448 rs999336748	124	H>Y		No	ClinGen TOPMed
CA8136760 rs755501551	125	I>L		No	ClinGen ExAC TOPMed gnomAD
CA283392445 rs755501551	125	I>V		No	ClinGen ExAC TOPMed gnomAD
rs981358617 CA283392441	126	S>F		No	ClinGen gnomAD
rs1241915005 CA396501038	129	H>R		No	ClinGen gnomAD
rs751320087 CA8136754	133	K>*		No	ClinGen ExAC TOPMed gnomAD
CA8136753 rs751320087	133	K>E		No	ClinGen ExAC TOPMed gnomAD
CA396501015 rs751320087	133	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1350384735 CA396501013	133	K>R		No	ClinGen gnomAD
rs376673166	134	P>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1384426386 CA396500995	134	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA283392271 rs1034084821	135	K>N		No	ClinGen TOPMed
rs1446436729 CA396500982	136	P>S		No	ClinGen gnomAD
rs1597617047 CA396500977	137	P>A		No	ClinGen Ensembl
rs1413887220 CA396500973	137	P>L		No	ClinGen gnomAD
rs1185439446 CA396500969	138	Q>E		No	ClinGen gnomAD
rs1243509562 CA396500953	140	T>A		No	ClinGen gnomAD
rs556913653 CA8136732	141	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1291566861 CA396500935	142	K>N		No	ClinGen gnomAD
rs373929661 CA8136731	143	G>R		No	ClinGen ESP ExAC gnomAD
CA283392255 rs898759808	145	S>P		No	ClinGen Ensembl
rs1567643525 CA396500910	146	A>V		No	ClinGen Ensembl
CA396500896 rs1399909961	148	E>V		No	ClinGen TOPMed
CA8136726 rs759429035	154	F>L		No	ClinGen ExAC gnomAD
CA396500841 rs1400896972	156	S>P		No	ClinGen gnomAD
CA8136725 rs199909206	158	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA283392226 rs1056809288	160	W>R		No	ClinGen Ensembl
CA8136723 rs767516188	163	P>S		No	ClinGen ExAC TOPMed gnomAD
CA283392214 rs977069740	165	P>R		No	ClinGen TOPMed gnomAD
rs1407742102 CA396500744	165	P>S		No	ClinGen gnomAD
rs1407742102 CA396500743	165	P>T		No	ClinGen gnomAD
CA8136720 rs774712134	166	N>S		No	ClinGen ExAC TOPMed gnomAD
CA283392208 rs774712134	166	N>T		No	ClinGen ExAC TOPMed gnomAD
rs369130166 CA396500698	167	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA396500664 rs1489726256	169	H>Y		No	ClinGen gnomAD
CA396500648 rs1453021765	170	E>K		No	ClinGen TOPMed
CA8136716 rs770299144	171	L>P		No	ClinGen ExAC gnomAD
rs775760815 CA8136717	171	L>V		No	ClinGen ExAC gnomAD
rs1260143759 CA396500610	172	Q>*		No	ClinGen TOPMed gnomAD
rs780699346 CA8136715	172	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs780699346 CA8136714	172	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA283392173 rs377474731	174	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136690 rs142056738	176	I>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8136689 rs548802495	176	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396500486 rs1378573901	177	D>Y		No	ClinGen gnomAD
CA396500469 rs1179360018	178	R>I		No	ClinGen TOPMed
CA8136688 rs778711110	179	G>S		No	ClinGen ExAC gnomAD
CA396500448 rs917744432	180	E>D		No	ClinGen TOPMed gnomAD
CA283392004 rs200787858	180	E>V		No	ClinGen 1000Genomes
CA8136686 rs749166459	182	V>I		No	ClinGen ExAC gnomAD
rs1254223112 CA396500412	184	S>N		No	ClinGen gnomAD
rs1056588735 CA283391991	185	E>K		No	ClinGen Ensembl
rs1202379888 CA396500388	186	E>Q		No	ClinGen TOPMed gnomAD
rs141066738 CA396500371	187	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs141066738 CA8136685	187	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA396500375 rs1483739204	187	E>Q		No	ClinGen TOPMed gnomAD
rs756162538 CA396500367	188	E>*		No	ClinGen ExAC TOPMed gnomAD
rs756162538 CA8136684	188	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs764295087 CA8136679	193	G>R		No	ClinGen ExAC TOPMed gnomAD
rs148140126 CA8136678	194	F>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs201940286 CA8136676	200	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136677 rs373901607	200	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1362884821 CA396500222	202	D>N		No	ClinGen TOPMed gnomAD
rs569301973 CA8136673	204	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs202043710 CA396500199	205	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8136671 rs772658224	205	G>R		No	ClinGen ExAC TOPMed gnomAD
rs202043710 CA8136669	205	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8136668 rs532411017	206	G>D		No	ClinGen 1000Genomes ExAC gnomAD
CA396500197 rs1460541902	206	G>S		No	ClinGen TOPMed
rs1214772070	206	G>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA283391920 rs975716353	208	W>R		No	ClinGen Ensembl
rs964023145 CA283391917	209	I>V		No	ClinGen Ensembl
CA396500172 rs1597616806	210	T>P		No	ClinGen Ensembl
rs1286547659 CA396500159	212	S>G		No	ClinGen gnomAD
rs1221651110 CA396500138	214	I>M		No	ClinGen TOPMed gnomAD
rs1597616794 CA396500142	214	I>V		No	ClinGen Ensembl
rs773862518 CA8136667	215	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8136665 rs749007038	216	Q>H		No	ClinGen ExAC gnomAD
rs780029064 CA8136664	218	Q>H		No	ClinGen ExAC gnomAD
CA396500105 rs1311499490	219	Q>K		No	ClinGen TOPMed
rs1292954268 CA396499538	220	E>G		No	ClinGen gnomAD
CA396499487 rs1299260798	221	L>Q		No	ClinGen gnomAD
CA396499496 rs1299260798	221	L>R		No	ClinGen gnomAD
CA8136662 rs745817578	221	L>V		No	ClinGen ExAC gnomAD
rs777937553 CA8136661	223	Q>P		No	ClinGen ExAC gnomAD
CA8136656 rs754109316	226	V>A		No	ClinGen ExAC gnomAD
rs140707395 CA8136658	226	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140707395 CA8136657	226	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761111639 CA8136654	228	E>K		No	ClinGen ExAC TOPMed gnomAD
CA396499317 rs1209849346	229	D>N		No	ClinGen TOPMed
rs528824487 CA8136652 CA396499291	230	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8136651 rs528824487	230	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs3811348 CA396499277	231	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8136648 rs3811348 VAR_050287	231	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8136649 rs370794024	231	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136646 rs543289898	232	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs543289898 CA8136647	232	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA8136645 rs377576075	233	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1404742484 CA396499198	236	T>S		No	ClinGen gnomAD
CA8136644 rs781258553	236	T>S		No	ClinGen ExAC TOPMed gnomAD
CA396499182 rs1326084748	237	T>A		No	ClinGen gnomAD
rs1387920117 CA396499172	237	T>I		No	ClinGen gnomAD
rs1233823580 CA396499126	240	A>G		No	ClinGen gnomAD
CA8136643 rs748142401	240	A>S		No	ClinGen ExAC TOPMed gnomAD
rs748142401 CA8136642	240	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8136641 rs147575559	241	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396499123 rs1424638075	241	M>L		No	ClinGen gnomAD
CA396498958 rs1156979781	246	L>P		No	ClinGen TOPMed
rs770730342 CA8136623	247	Q>K		No	ClinGen ExAC gnomAD
rs768785553 CA8136620	251	H>P		No	ClinGen ExAC TOPMed gnomAD
rs1281094692 CA396498875	251	H>Y		No	ClinGen gnomAD
CA8136618 rs558915977	252	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs558915977 CA8136617	252	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs746189885 CA8136616	254	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8136614 rs757644602	255	V>A		No	ClinGen ExAC gnomAD
rs757644602 CA396498834	255	V>G		No	ClinGen ExAC gnomAD
CA283391429 rs867680314	257	G>D		No	ClinGen Ensembl
CA8136612 rs143188741	257	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA396498771 rs1418901500	258	M>I		No	ClinGen gnomAD
CA8136611 rs757908565	258	M>R		No	ClinGen ExAC gnomAD
CA396498747 rs1358433967	260	I>T		No	ClinGen gnomAD
rs759296939 CA396498740	261	R>C		No	ClinGen ExAC TOPMed gnomAD
rs759296939 CA8136609	261	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8136606 rs766211851	261	R>H		No	ClinGen ExAC TOPMed gnomAD
rs766211851 CA8136607	261	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8136608 rs759296939	261	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1179619965 CA396498732	262	E>K		No	ClinGen gnomAD
CA283391409 rs140750415	263	A>T		No	ClinGen ESP gnomAD
CA8136605 rs144951532	263	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775577759 CA8136601	264	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs749334665 CA8136602	264	R>W		No	ClinGen ExAC TOPMed gnomAD
rs555253831 CA8136600	265	S>G		No	ClinGen 1000Genomes ExAC gnomAD
rs746101501 CA8136599	267	I>V		No	ClinGen ExAC TOPMed gnomAD
rs149902028 CA8136597	269	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149902028 CA8136598	269	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199699618 CA8136595 COSM1217537	269	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs199699618 CA8136596	269	R>L		No	ClinGen ExAC TOPMed gnomAD
rs759018028 CA8136594	270	C>G		No	ClinGen ExAC gnomAD
rs752218885 CA8136593	271	H>R		No	ClinGen ExAC gnomAD
CA283391353 rs201781279	273	C>W		No	ClinGen Ensembl
rs1338140443 CA396498602 CA396498604	274	F>L		No	ClinGen TOPMed gnomAD
CA8136591 rs199696552	275	K>E		No	ClinGen 1000Genomes ExAC TOPMed
rs551815268 CA8136590	275	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8136568 rs139171866	277	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140714914 CA8136567	277	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140714914 CA396498235	277	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8136564 rs751491953	280	M>L		No	ClinGen ExAC gnomAD
CA8136563 rs764073447	280	M>T		No	ClinGen ExAC gnomAD
CA396498210 rs751491953	280	M>V		No	ClinGen ExAC gnomAD
rs373158111 CA8136562	282	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373158111 CA8136561 COSM1379256	282	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1450012038 CA396498176	283	V>M		No	ClinGen TOPMed
TCGA novel	284	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1456578440 CA396498149	285	C>G		No	ClinGen gnomAD
CA8136559 rs760833894	286	S>L		No	ClinGen ExAC TOPMed gnomAD
CA8136560 rs771149481	286	S>P		No	ClinGen ExAC gnomAD
rs1299005087 CA396498123	287	H>R		No	ClinGen gnomAD
rs369384135 CA8136558	287	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs144374127 CA8136557	288	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs144374127 CA8136556	288	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136554 rs769336680	290	N>D		No	ClinGen ExAC gnomAD
rs748801425 CA8136553	290	N>K		No	ClinGen ExAC gnomAD
rs779451471 CA396498070	291	K>N		No	ClinGen ExAC TOPMed gnomAD
rs140632082 CA8136551	292	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs569105886 CA8136550	294	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA8136549 rs780887579	295	K>N		No	ClinGen ExAC gnomAD
rs1465285998 CA396498019	296	V>A		No	ClinGen TOPMed gnomAD
rs1435373076 CA396498006	297	S>F		No	ClinGen TOPMed gnomAD
TCGA novel	297	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201329814 CA8136546	297	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA283389207 rs372933003	298	V>M		No	ClinGen ESP TOPMed gnomAD
CA8136544 rs753909517	299	T>A		No	ClinGen ExAC gnomAD
rs1240163234 CA396497983	299	T>I		No	ClinGen gnomAD
rs200093997 CA8136541	300	V>I		No	ClinGen ExAC gnomAD
rs762247376 CA8136539	301	S>N		No	ClinGen ExAC gnomAD
CA8136540 rs550706516	301	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1246987821 CA396497942	302	D>H		No	ClinGen TOPMed
rs749772355 CA8136536	303	D>N		No	ClinGen ExAC gnomAD
rs375951032 CA8136534	304	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs745439543 CA8136533	306	L>P		No	ClinGen ExAC gnomAD
CA8136531 rs756940203	308	M>T		No	ClinGen ExAC gnomAD
rs1301418374 CA396497827	308	M>V		No	ClinGen gnomAD
rs1158556594 CA396497809	309	H>R		No	ClinGen gnomAD
CA8136530 rs746762242	309	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1382174482 CA396497780	312	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8136527 rs143009356	312	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA283389142 rs143009356	312	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8136528 rs143009356	312	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8136525 rs756136944	314	P>L		No	ClinGen ExAC gnomAD
rs921404406 CA283389124	315	K>R		No	ClinGen Ensembl
CA396497731 rs1169076635	316	V>A		No	ClinGen TOPMed
rs1183861633 CA396497718	317	L>V		No	ClinGen TOPMed gnomAD
rs1041253548 CA283389119	318	N>H		No	ClinGen TOPMed
CA283389114 rs1025882909	318	N>K		No	ClinGen TOPMed gnomAD
CA8136524 rs750581436	318	N>S		No	ClinGen ExAC gnomAD
CA283389110 rs944434138	319	P>A		No	ClinGen Ensembl
rs1355775499 CA396497168	319	P>H		No	ClinGen gnomAD
CA283389097 rs201985418	320	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8136522 rs201985418	320	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774798065 CA8136521	320	R>H		No	ClinGen ExAC TOPMed gnomAD
CA396497143 rs763441100	321	G>R		No	ClinGen ExAC TOPMed
rs763441100 CA8136519	321	G>S		No	ClinGen ExAC TOPMed
CA8136518 rs775844742	322	L>F		No	ClinGen ExAC gnomAD
CA8136516 rs575122853	323	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770379216 CA8136517	323	R>W		No	ClinGen ExAC gnomAD
CA396496366 rs199696927	324	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA8136491 rs199696927	324	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs771807789 CA8136490	325	S>L		No	ClinGen ExAC gnomAD
CA8136485 rs780207082	327	P>T		No	ClinGen ExAC gnomAD
rs1597613685 CA396496308	328	T>I		No	ClinGen Ensembl
CA396496305 rs1194829691	329	P>S		No	ClinGen gnomAD
CA8136483 rs751735190	331	G>A		No	ClinGen ExAC TOPMed gnomAD
rs751735190 CA8136484	331	G>E		No	ClinGen ExAC TOPMed gnomAD
CA283387584 rs943498114	332	G>A		No	ClinGen Ensembl
rs1405616927 CA396496280	333	K>R		No	ClinGen TOPMed
TCGA novel rs199873991 CA283387574	334	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
rs374897147 CA8136481	334	Y>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136480 rs200973241	335	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA283387571 rs1052182555	335	A>V		No	ClinGen TOPMed
CA8136479 rs769656111	337	N>S		No	ClinGen ExAC gnomAD
rs769656111 CA396496228	337	N>T		No	ClinGen ExAC gnomAD
rs1476970336 CA396496218	338	P>T		No	ClinGen gnomAD
CA396496204 rs562027876	339	H>D		No	ClinGen 1000Genomes ExAC gnomAD
CA8136476 rs148297045	339	H>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA283387565 rs148297045	339	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs562027876 CA8136477	339	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA396496191 rs1234505164	340	L>V		No	ClinGen TOPMed
CA283387561 rs933762241	341	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA8136471 rs773950270	342	E>*		No	ClinGen ExAC TOPMed gnomAD
rs768566151 CA8136470	342	E>A		No	ClinGen ExAC TOPMed gnomAD
CA396496149 rs1438054016	342	E>D		No	ClinGen TOPMed
CA8136472 rs773950270	342	E>K		No	ClinGen ExAC TOPMed gnomAD
CA396496148 rs1200263600	343	D>N		No	ClinGen TOPMed gnomAD
rs1200263600 CA396496143	343	D>Y		No	ClinGen TOPMed gnomAD
rs144311268 CA8136468	344	Q>E		No	ClinGen ESP ExAC gnomAD
rs367776601 CA8136467 COSM417300	345	R>C	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA8136466 rs202231111	345	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8136465 rs202231111	345	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752972297 CA8136463	347	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8136460 rs200241603	350	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1168412771 CA396496033	350	R>Q		No	ClinGen TOPMed
CA396496011 rs749853972	352	S>A		No	ClinGen ExAC TOPMed gnomAD
CA8136455 rs767068331	352	S>C		No	ClinGen ExAC TOPMed gnomAD
rs749853972 CA8136456	352	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1402165712 CA396496001	353	Q>*		No	ClinGen TOPMed
CA8136454 rs149583705	353	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200699147 CA283387502	354	K>M		No	ClinGen TOPMed
rs959461388 CA283387501	357	Q>*		No	ClinGen Ensembl
CA396495916 rs1470281461	359	T>A		No	ClinGen TOPMed gnomAD
rs1470281461 CA396495918	359	T>P		No	ClinGen TOPMed gnomAD
CA396495912 rs1567641218	359	T>S		No	ClinGen Ensembl
rs770744330 CA8136452	361	V>M		No	ClinGen ExAC TOPMed gnomAD
rs199823310 CA8136450 CA8136449	362	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs200963044 CA8136448	363	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136447 rs773101833	364	P>A		No	ClinGen ExAC gnomAD
CA396495817 rs1283799001	365	D>E		No	ClinGen TOPMed gnomAD
CA8136445 rs748236455	365	D>G		No	ClinGen ExAC gnomAD
CA8136446 rs772192178	365	D>N		No	ClinGen ExAC gnomAD
CA396495809 rs1075935	366	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8136444 rs1075935 VAR_050288	366	Y>F		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs755234226 CA396495802	367	I>F		No	ClinGen ExAC gnomAD
rs371437900 CA8136442	367	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs755234226 CA8136443	367	I>V		No	ClinGen ExAC gnomAD
CA8136440 rs750935720	368	A>S		No	ClinGen ExAC TOPMed gnomAD
rs750935720 CA8136439	368	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8136438 rs767966673	368	A>V		No	ClinGen ExAC TOPMed gnomAD
rs150459642 CA8136436	369	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136435 rs763796065	369	G>V		No	ClinGen ExAC gnomAD
CA396495743 rs150459642	369	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136433 rs775362926	371	S>L		No	ClinGen ExAC TOPMed gnomAD
CA8136432 rs765124938	372	P>L		No	ClinGen ExAC gnomAD
CA396495701 rs1189121083	372	P>T		No	ClinGen gnomAD
rs759320295 CA396495694	373	F>I		No	ClinGen ExAC gnomAD
rs759320295 CA8136431	373	F>V		No	ClinGen ExAC gnomAD
rs770825976 CA8136429	375	E>K		No	ClinGen ExAC TOPMed gnomAD
rs368680835 CA396495626	377	D>H		No	ClinGen ESP TOPMed gnomAD
rs368680835 CA283387437	377	D>N		No	ClinGen ESP TOPMed gnomAD
rs748231308 CA8136428	377	D>V		No	ClinGen ExAC gnomAD
CA396495607 rs1337242239	378	I>F		No	ClinGen gnomAD
CA396495609 rs1337242239	378	I>V		No	ClinGen gnomAD
CA8136427 rs112175164	379	S>P		No	ClinGen ExAC gnomAD
CA283387434 rs112175164	379	S>T		No	ClinGen ExAC gnomAD
rs145274258 CA8136425 COSM1379254	381	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA396495580 rs1290543750	381	R>H		No	ClinGen TOPMed gnomAD
CA396495578 rs1290543750	381	R>L		No	ClinGen TOPMed gnomAD
rs756486064 CA8136423	382	S>L		No	ClinGen ExAC gnomAD
CA396495527 rs1462644831	385	L>P		No	ClinGen TOPMed gnomAD
CA396495525 rs1462644831	385	L>R		No	ClinGen TOPMed gnomAD
CA396495506 rs1454881326	386	Q>H		No	ClinGen TOPMed
CA8136421 rs781701396	386	Q>R		No	ClinGen ExAC gnomAD
rs920287409 CA283387421	387	V>I		No	ClinGen TOPMed
CA8136420 rs757734469	388	R>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	388	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs567828761 CA8136419	388	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA283387419 rs757734469	388	R>W		No	ClinGen ExAC TOPMed gnomAD
rs907698855 CA283387403	389	D>N		No	ClinGen TOPMed gnomAD
CA8136417 rs192458406	390	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8136414 rs61731358	393	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8136415 rs765043201	393	G>R		No	ClinGen ExAC TOPMed gnomAD
CA8136413 rs753620220	395	G>E		No	ClinGen ExAC TOPMed gnomAD
CA396495372 rs1274010799	395	G>R		No	ClinGen gnomAD
rs372678543 CA8136411	396	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8136412 rs200044448	396	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774359564 CA8136410	397	R>S		No	ClinGen ExAC gnomAD
CA8136409 rs768728190	398	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763077738 CA8136408	398	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1394647849 CA396495336	399	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1349874888 CA396495309	401	P>S		No	ClinGen TOPMed
rs1022069775 CA283387375	402	N>H		No	ClinGen TOPMed
rs769948978 CA8136406	402	N>S		No	ClinGen ExAC TOPMed gnomAD
rs956504618 CA283387365	403	A>T		No	ClinGen TOPMed gnomAD
CA396495259 rs1439589272	406	K>R		No	ClinGen TOPMed
rs372723562 CA396495240	407	K>N		No	ClinGen ESP TOPMed
rs771407166 CA8136403	407	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs939689278 CA283387336	410	K>R		No	ClinGen TOPMed
rs778486819 CA396495204	411	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1324744330 CA396495188	413	R>C		No	ClinGen TOPMed
CA396495191 rs1456621000	413	R>L		No	ClinGen gnomAD

No associated diseases with Q9ULX3

4 regional properties for Q9ULX3

Type	Name	Position	InterPro Accession
domain	PIN domain	5 - 108	IPR002716
domain	Nin one binding (NOB1) Zn-ribbon-like	260 - 332	IPR014881
domain	Ribonuclease, PIN domain	7 - 109	IPR033411
domain	Putative WW-binding domain and destruction box	153 - 212	IPR033461

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
preribosome, small subunit precursor	A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

2 GO annotations of molecular function

Name	Definition
endoribonuclease activity	Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
metal ion binding	Binding to a metal ion.

4 GO annotations of biological process

Name	Definition
cleavage involved in rRNA processing	Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule.
maturation of SSU-rRNA	Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
visual perception	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3T042	NOB1	RNA-binding protein NOB1	Bos taurus (Bovine)	PR
Q8BW10	Nob1	RNA-binding protein NOB1	Mus musculus (Mouse)	PR
Q6VEU1	Nob1	RNA-binding protein NOB1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MAPVEHVVAD	AGAFLRHAAL	QDIGKNIYTI	REVVTEIRDK	ATRRRLAVLP	YELRFKEPLP
70	80	90	100	110	120
EYVRLVTEFS	KKTGDYPSLS	ATDIQVLALT	YQLEAEFVGV	SHLKQEPQKV	KVSSSIQHPE
130	140	150	160	170	180
TPLHISGFHL	PYKPKPPQET	EKGHSACEPE	NLEFSSFMFW	RNPLPNIDHE	LQELLIDRGE
190	200	210	220	230	240
DVPSEEEEEE	ENGFEDRKDD	SDDDGGGWIT	PSNIKQIQQE	LEQCDVPEDV	RVGCLTTDFA
250	260	270	280	290	300
MQNVLLQMGL	HVLAVNGMLI	REARSYILRC	HGCFKTTSDM	SRVFCSHCGN	KTLKKVSVTV
310	320	330	340	350	360
SDDGTLHMHF	SRNPKVLNPR	GLRYSLPTPK	GGKYAINPHL	TEDQRFPQLR	LSQKARQKTN
370	380	390	400	410
VFAPDYIAGV	SPFVENDISS	RSATLQVRDS	TLGAGRRRLN	PNASRKKFVK	KR