Q8BW10
Gene name |
Nob1 |
Protein name |
RNA-binding protein NOB1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67619 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q8BW10
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2CON | NMR | - | A | 251-316 | PDB |
| AF-Q8BW10-F1 | Predicted | AlphaFoldDB |
26 variants for Q8BW10
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs249892421 | 30 | I>L | No | EVA | |
| rs3389010059 | 46 | L>M | No | EVA | |
| rs37220717 | 54 | R>Q | No | EVA | |
| rs3389013934 | 74 | G>W | No | EVA | |
| rs3389007113 | 79 | L>I | No | EVA | |
| rs586060616 | 124 | H>Y | No | EVA | |
| rs3388959991 | 145 | H>Y | No | EVA | |
| rs3389011148 | 152 | N>K | No | EVA | |
| rs3388985485 | 153 | L>P | No | EVA | |
| rs3388996895 | 211 | E>* | No | EVA | |
| rs3389002900 | 213 | E>G | No | EVA | |
| rs3389011154 | 221 | V>L | No | EVA | |
| rs3389011150 | 243 | V>L | No | EVA | |
| rs3389009870 | 246 | V>L | No | EVA | |
| rs3388959985 | 254 | A>V | No | EVA | |
| rs3388991000 | 256 | S>I | No | EVA | |
| rs3389013926 | 284 | L>R | No | EVA | |
| rs3389014867 | 287 | V>M | No | EVA | |
| rs3389002073 | 310 | P>T | No | EVA | |
| rs3412964940 | 334 | D>E | No | EVA | |
| rs3388979089 | 335 | Q>R | No | EVA | |
| rs3389009862 | 355 | P>H | No | EVA | |
| rs3389009904 | 365 | A>V | No | EVA | |
| rs38125879 | 381 | G>S | No | EVA | |
| rs3389006712 | 384 | G>* | No | EVA | |
| rs3388996941 | 385 | A>G | No | EVA |
No associated diseases with Q8BW10
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| preribosome, small subunit precursor | A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| endoribonuclease activity | Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
| metal ion binding | Binding to a metal ion. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cleavage involved in rRNA processing | Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. |
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
| ribosomal small subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPVEHVVAD | AGAFLRDAPL | QDIGKNIYTI | REVVREIRDK | ATRRRLAVLP | YQLRFKEPLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EYVRLVTEFS | KKTGDYPSLS | ATDIQVLALT | YQLEAEFVGV | SHLKKEPEKA | KVSSSIQHPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TALHISGFHL | PSKSKPLQEA | VDRGHAADGP | ENLEFSSFMF | WRTPLPNIDR | ELQELLIDGR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEEEEEEECE | DSDDDGGGWI | TPSNIKQIQQ | ELEQCDTPED | VQVGCVTTDF | AMQNVLLQMG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LHVLAVNGML | VREARSYILR | CHGCFKTTSD | MNRVFCGHCG | NKTLKKVSVT | INDDGTLHMH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSRNPKVLNP | RGLRYSLPTP | KGGKYAINPH | LTEDQRFPQL | RLSQKARQKT | DVFAPDYIAG |
| 370 | 380 | 390 | 400 | ||
| VSPFAENDIS | SRSAILQVRD | GMLGAGRRRL | NPNASRKKFV | KKR |