AiPD: Autoinhibited Protein Database

Q9ULU8

Gene name	CADPS (CAPS, CAPS1, KIAA1121)
Protein name	Calcium-dependent secretion activator 1
Names	Calcium-dependent activator protein for secretion 1, CAPS-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8618
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-132 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

55-132 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9ULU8

Entry ID	Method	Resolution	Chain	Position	Source
1WI1	NMR	-	A	522-634	PDB
AF-Q9ULU8-F1	Predicted				AlphaFoldDB

930 variants for Q9ULU8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA174902 COSM1179562 rs193921128 COSM1179563 RCV000149385	162	A>T	Malignant tumor of prostate prostate [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar dbSNP gnomAD
CA2477366 rs753008027	3	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1234944909 CA353535399	4	P>L		No	ClinGen TOPMed
rs759782285 CA2477364	6	S>T		No	ClinGen ExAC TOPMed gnomAD
CA353535390 rs1228373744	6	S>Y		No	ClinGen gnomAD
rs1300303855 CA353535386	7	S>G		No	ClinGen gnomAD
TCGA novel	10	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353535359 rs1346483473	10	E>G		No	ClinGen TOPMed
rs1339522614 CA353535348	12	D>N		No	ClinGen gnomAD
CA2477363 rs776782869	13	E>K		No	ClinGen ExAC TOPMed gnomAD
rs201514742 COSM1538354 COSM1538353 CA353535330	14	I>M	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs770846736 CA2477362	14	I>T		No	ClinGen ExAC TOPMed gnomAD
CA75893430 rs903562646	14	I>V		No	ClinGen TOPMed
rs1199810382 CA353535327	15	V>L		No	ClinGen TOPMed
CA353535304 rs1427790288	18	E>K		No	ClinGen gnomAD
rs772478182 CA2477358	19	S>N		No	ClinGen ExAC TOPMed gnomAD
CA353535292 rs774661931 CA2477356	19	S>R		No	ClinGen ExAC TOPMed gnomAD
CA353535290 rs768322888	20	G>C		No	ClinGen ExAC gnomAD
CA2477355 rs768322888	20	G>S		No	ClinGen ExAC gnomAD
rs748835245 CA75893417	23	V>L		No	ClinGen ExAC TOPMed gnomAD
rs748835245 CA2477354	23	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1181909351 CA353535248	26	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1310801317 CA353535245	27	A>T		No	ClinGen TOPMed
rs1482373470 CA353535242	27	A>V		No	ClinGen gnomAD
rs757218775 CA353535237	28	P>L		No	ClinGen ExAC TOPMed gnomAD
rs757218775 CA2477349	28	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1358240148 CA353535228	30	G>D		No	ClinGen TOPMed
rs751422032 CA2477348	30	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1355510786 CA353535220	31	A>V		No	ClinGen gnomAD
CA2477346 rs755251601	32	R>H		No	ClinGen ExAC TOPMed gnomAD
rs755251601 CA353535215	32	R>L		No	ClinGen ExAC TOPMed gnomAD
CA353535191 rs1329532583	36	S>R		No	ClinGen TOPMed gnomAD
rs1404534547 CA353535188	37	R>G		No	ClinGen gnomAD
rs574548082 CA2477343	37	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs574548082 CA75893406	37	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353535182 rs1458758426	38	T>N		No	ClinGen TOPMed
TCGA novel	40	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353535162 rs1162980465	41	G>S		No	ClinGen TOPMed
CA353535153 rs1393289371	42	S>W		No	ClinGen TOPMed
rs1418603207 CA353535146	43	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	45	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774712790 CA2477339	45	S>R		No	ClinGen ExAC TOPMed gnomAD
CA353535131 rs1254588183	46	A>S		No	ClinGen gnomAD
CA353535122 rs1451372707	47	G>A		No	ClinGen TOPMed gnomAD
CA353535114 rs1288222212	49	G>R		No	ClinGen TOPMed gnomAD
rs768942724 CA2477338	49	G>V		No	ClinGen ExAC gnomAD
CA353535113 rs1288222212	49	G>W		No	ClinGen TOPMed gnomAD
rs1266879415	50	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA353535107 rs1335105830	50	G>D		No	ClinGen TOPMed gnomAD
CA353535109 rs1333040025	50	G>R		No	ClinGen TOPMed
rs1258843946 CA353535104	51	G>C		No	ClinGen TOPMed
CA353535093 rs1480368155	52	G>V		No	ClinGen TOPMed
CA2477337 rs749038689	53	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1351858286 CA353535087	54	G>S		No	ClinGen TOPMed gnomAD
rs903630359 CA75893398	54	G>V		No	ClinGen TOPMed
CA353535082 rs1461055146	55	A>T		No	ClinGen TOPMed
CA353535075 rs1295879050	56	G>R		No	ClinGen TOPMed
rs966452381 CA75893394	59	V>G		No	ClinGen Ensembl
rs1307082377 CA353535050	60	G>D		No	ClinGen TOPMed
rs1202535271 CA353535033	63	G>C		No	ClinGen TOPMed
CA353535020 rs1387868263	65	G>E		No	ClinGen gnomAD
rs1210752627 CA353535023	65	G>R		No	ClinGen TOPMed
CA353535017 rs1329096152	66	G>C		No	ClinGen TOPMed gnomAD
rs556260817 CA75893392	68	G>C		No	ClinGen 1000Genomes gnomAD
CA353534990 rs1158794212	70	S>C		No	ClinGen TOPMed gnomAD
rs1158794212 CA353534991	70	S>G		No	ClinGen TOPMed gnomAD
CA353534956 rs1298515899	75	A>S		No	ClinGen TOPMed
rs1553808893 CA2477334	75	A>V		No	ClinGen Ensembl
CA353534949 rs1577765614	76	G>E		No	ClinGen Ensembl
rs1200827323 CA353534943	77	G>A		No	ClinGen TOPMed gnomAD
rs1200827323 CA353534944	77	G>E		No	ClinGen TOPMed gnomAD
rs1560049709 CA353534923	80	P>R		No	ClinGen Ensembl
CA353534907 rs745400126	82	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1245298719 CA353534891	85	G>D		No	ClinGen gnomAD
COSM404608 rs757273840 CA2477330 COSM404607	87	G>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1241887408 CA353534880	87	G>D		No	ClinGen TOPMed
CA353534876 rs1206486296	88	R>W		No	ClinGen gnomAD
rs1218523580 CA353534859	91	S>G		No	ClinGen gnomAD
CA2477327 rs758112611	92	P>S		No	ClinGen ExAC gnomAD
TCGA novel	93	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1364266570 CA353534834	94	P>L		No	ClinGen TOPMed gnomAD
CA353534828 rs1433222269	95	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs754135566 CA2477326	96	V>A		No	ClinGen ExAC gnomAD
rs1159956710 CA353534825	96	V>L		No	ClinGen gnomAD
CA353534827 rs1159956710	96	V>M		No	ClinGen gnomAD
CA353534818 rs1172399849	97	V>A		No	ClinGen TOPMed
rs1423695828 CA353534816	98	S>C		No	ClinGen gnomAD
CA2477325 rs766482938 CA353534810	98	S>R		No	ClinGen ExAC gnomAD
rs1454960732 CA353534805	99	E>G		No	ClinGen gnomAD
CA2477323 rs373181966	103	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1242130335 CA353534770	104	E>K		No	ClinGen gnomAD
CA353534769 rs1242130335	104	E>Q		No	ClinGen gnomAD
rs146998598 CA2477320	106	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353534748 rs1282365865	107	R>G		No	ClinGen TOPMed gnomAD
rs1341159314 CA353534738	109	Q>E		No	ClinGen TOPMed gnomAD
CA353534734 rs1295171104	109	Q>R		No	ClinGen gnomAD
CA353534730 rs1577761908	110	K>Q		No	ClinGen Ensembl
rs1315529251 CA353534726	110	K>R		No	ClinGen TOPMed
rs1336807592 CA353534721	111	E>Q		No	ClinGen gnomAD
rs1226398589 CA353534714	112	E>K		No	ClinGen gnomAD
rs762313702 CA2477319	113	E>Q		No	ClinGen ExAC gnomAD
rs1315314790 CA353534687	115	R>K		No	ClinGen TOPMed gnomAD
CA353534685 rs1192523473	115	R>S		No	ClinGen TOPMed
rs140977565 CA353534670	117	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA75893367 rs911062205	121	L>V		No	ClinGen TOPMed gnomAD
rs142784700 CA353534621 CA353534622	125	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs142784700 CA2477316	125	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1395567771 CA353534608	127	R>S		No	ClinGen TOPMed
CA75893365 rs867074864	130	A>S		No	ClinGen TOPMed
CA353534586 rs867074864	130	A>T		No	ClinGen TOPMed
CA353534574 rs763206239	132	P>A		No	ClinGen ExAC gnomAD
rs763206239 CA2477315	132	P>T		No	ClinGen ExAC gnomAD
TCGA novel	135	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353534541 rs1211458493	136	K>N		No	ClinGen TOPMed gnomAD
CA353534539 rs1482702155	137	Q>*		No	ClinGen gnomAD
CA75893358 rs868252043	140	D>N		No	ClinGen Ensembl
CA75893357 rs1047897183	141	M>K		No	ClinGen gnomAD
rs1047897183 CA353534508	141	M>T		No	ClinGen gnomAD
CA353534492 rs759170162	144	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1397886005 CA353534303	148	I>L		No	ClinGen TOPMed
CA353534292 rs1161144698	149	S>N		No	ClinGen gnomAD
rs1346064043 CA353534277	151	Q>L		No	ClinGen TOPMed
CA2477287 rs768495306	153	L>Q		No	ClinGen ExAC gnomAD
CA75871575 rs758428664	154	Q>R		No	ClinGen gnomAD
CA353534244 COSM1617986 COSM1617987 rs1189252775	156	V>D	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
CA353534235 rs1469702462	157	K>N		No	ClinGen TOPMed gnomAD
CA2477285 rs781371846	159	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2477284 rs757369103	159	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1247238 COSM1247237 CA75871574 rs781371846	159	R>W	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs751660042 CA2477283	161	Q>*		No	ClinGen ExAC gnomAD
CA353534207 rs193921128	162	A>S		No	ClinGen gnomAD
rs1352029648 CA353534199	163	F>C		No	ClinGen TOPMed
CA2477282 rs777849521	163	F>L		No	ClinGen ExAC
rs1225176813 CA353534196	164	L>I		No	ClinGen TOPMed
rs374048491 CA2477281 COSM393621 COSM393620	165	N>S	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1439156922 CA353534177	167	E>Q		No	ClinGen gnomAD
CA2477279 rs765574786	168	T>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	169	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA75871573 rs1012911039	169	Q>P		No	ClinGen TOPMed gnomAD
rs551771748 CA2477276	171	M>I		No	ClinGen 1000Genomes ExAC gnomAD
CA2477277 rs753582174	171	M>V		No	ClinGen ExAC TOPMed gnomAD
rs202064143 CA2477273	173	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2477274 rs772865797	173	D>G		No	ClinGen ExAC gnomAD
CA353534131 rs1395502026	174	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA353534120 rs1576084107	175	A>G		No	ClinGen Ensembl
rs1194460354 CA353534121	175	A>S		No	ClinGen gnomAD
CA353534104 rs1378685272	177	M>I		No	ClinGen TOPMed
CA2477272 rs761723810	177	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs768387474 CA353534096	178	N>K		No	ClinGen ExAC TOPMed gnomAD
CA2477271 rs774331824	178	N>Y		No	ClinGen ExAC TOPMed gnomAD
CA2477269 rs749053370	179	A>V		No	ClinGen ExAC
rs775215525 CA353534089	180	V>L		No	ClinGen ExAC TOPMed gnomAD
CA2477268 rs775215525	180	V>M		No	ClinGen ExAC TOPMed gnomAD
CA353534082 rs1255912612	181	Q>*		No	ClinGen gnomAD
rs946874983 CA75871571	181	Q>H		No	ClinGen gnomAD
rs1232809758 CA353534074	182	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353534070 rs1559522190	182	S>R		No	ClinGen Ensembl
rs771152842 CA353534062	183	Y>*		No	ClinGen ExAC gnomAD
CA353534057 rs1227135917	184	Y>C		No	ClinGen gnomAD
rs1304651123 CA353534060	184	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353534000 rs1416467974	189	K>T		No	ClinGen gnomAD
rs1356023572 CA353533993	190	S>C		No	ClinGen gnomAD
CA353533992 rs1307402806	190	S>N		No	ClinGen gnomAD
CA75870166 rs900216693	191	D>E		No	ClinGen Ensembl
rs764052619 CA2477253	191	D>N		No	ClinGen ExAC TOPMed gnomAD
CA353533982 rs764052619	191	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs762817680 CA2477252	192	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2477251 rs775267200	192	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1417176726 CA353533956 COSM331378 COSM331379	193	V>M	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs769571334 CA2477250	194	A>S		No	ClinGen ExAC TOPMed gnomAD
rs747289008 COSM1047988 COSM1047989 CA2477249	194	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2477248 COSM1047986 rs759883423 COSM1047987	195	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs748288278 CA2477246	195	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2477247 rs748288278	195	R>L		No	ClinGen ExAC TOPMed gnomAD
CA353533915 rs1575876279	196	M>I		No	ClinGen Ensembl
rs778806598 CA353533924	196	M>L		No	ClinGen ExAC TOPMed gnomAD
rs778806598 CA2477245 COSM133393	196	M>V	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1368260579 CA353533881	199	S>N		No	ClinGen TOPMed
rs1275578834 CA353533857	201	G>S		No	ClinGen gnomAD
rs780636772 CA2477242	204	A>T		No	ClinGen ExAC TOPMed gnomAD
CA353533791 rs149627119	205	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs756534479 CA2477241	205	N>S		No	ClinGen ExAC TOPMed gnomAD
CA75870165 rs567491404	207	S>Y		No	ClinGen TOPMed gnomAD
rs756821447 CA2477238	208	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs150525596 COSM3696236 COSM3696235 CA75870164	208	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1329305945 CA353533740	210	V>F		No	ClinGen TOPMed gnomAD
rs1575875445 CA353533736	210	V>G		No	ClinGen Ensembl
rs1329305945 CA353533742	210	V>I		No	ClinGen TOPMed gnomAD
rs201199713 CA2477236	215	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA2477233 rs765062014	219	V>E		No	ClinGen ExAC TOPMed gnomAD
CA2477234 rs752617298	219	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2477232 rs200699296	220	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2477231 rs776247631 COSM1238414 COSM1238415	220	R>H	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA353533589 rs776247631	220	R>L		No	ClinGen ExAC TOPMed gnomAD
CA2477229 rs201960341	221	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2477228 rs201960341	221	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1022786029 CA75870162	223	P>R		No	ClinGen TOPMed
CA353533536 rs1575874801	224	E>D		No	ClinGen Ensembl
CA2477226 rs372234823	227	G>S		No	ClinGen ESP ExAC TOPMed
rs770322543 CA2477224	229	S>R		No	ClinGen ExAC gnomAD
CA353533460 rs1266959466	230	K>R		No	ClinGen gnomAD
rs960807970 CA75870161	231	E>G		No	ClinGen TOPMed
TCGA novel	231	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353533446 rs960807970	231	E>V		No	ClinGen TOPMed
CA353533441 rs1575874444	232	T>A		No	ClinGen Ensembl
CA353533430 rs1183750573	232	T>I		No	ClinGen gnomAD
CA2477223 rs746277038	234	L>M		No	ClinGen ExAC gnomAD
CA2477222 rs781364132	238	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1280127722 CA353533337	239	A>D		No	ClinGen TOPMed gnomAD
TCGA novel	239	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1443665111 CA353533330	240	K>Q		No	ClinGen gnomAD
CA353533260 rs1443411062	245	Y>D		No	ClinGen gnomAD
rs757880751 CA2477218	246	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM1047983 rs752666502 COSM1047982 CA2477217	246	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA353533240 rs752666502	246	R>L		No	ClinGen ExAC TOPMed gnomAD
rs765186750 CA2477216	247	G>A		No	ClinGen ExAC gnomAD
CA353533231 rs765186750	247	G>E		No	ClinGen ExAC gnomAD
rs1575873511 CA353533195	250	D>A		No	ClinGen Ensembl
rs1454081764 CA353533199	250	D>Y		No	ClinGen gnomAD
rs759339095 CA2477215	251	P>L		No	ClinGen ExAC gnomAD
COSM1309428 CA75870159 COSM1309429 rs1022980072	252	R>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
COSM239135 CA353533168 rs149095712 COSM239134	252	R>W	endometrium prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1010534316 CA75870158	255	Q>P		No	ClinGen Ensembl
CA2477212 rs762164412	256	A>T		No	ClinGen ExAC gnomAD
rs774706010 CA2477211 COSM3824521 COSM3824520	256	A>V	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA353533111 rs1345412626	257	R>L		No	ClinGen gnomAD
CA353533113 rs1345412626	257	R>Q		No	ClinGen gnomAD
CA75870157 rs1017308312	257	R>W		No	ClinGen gnomAD
CA2477209 CA2477210 rs763095162	258	M>I		No	ClinGen ExAC gnomAD
CA75870156 CA353533110 rs374555826	258	M>L		No	ClinGen TOPMed
rs200446361 CA2477207	261	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs775673407 CA2477208	261	S>T		No	ClinGen ExAC gnomAD
COSM1309427 CA2477205 rs150415917 COSM1309426	262	A>T	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	263	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	264	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353533074 rs1428715095	264	S>P		No	ClinGen gnomAD
rs771185889 CA2477204	265	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353533061 rs1575872189	266	L>V		No	ClinGen Ensembl
rs746724636 CA2477203	268	L>M		No	ClinGen ExAC gnomAD
rs1373980414 CA353533030	271	E>K		No	ClinGen gnomAD
CA353533004 rs1245462818	274	Y>C		No	ClinGen gnomAD
CA75870154 rs1003851252	275	E>D		No	ClinGen TOPMed
CA75870153 rs776843736	277	F>L		No	ClinGen Ensembl
CA353532981 rs1418349931	277	F>Y		No	ClinGen gnomAD
CA2477201 rs758002941	278	Q>E		No	ClinGen ExAC gnomAD
CA2477200 rs372022670	280	I>V		No	ClinGen ESP ExAC gnomAD
CA353532955 rs778333875	281	L>F		No	ClinGen ExAC TOPMed gnomAD
rs778333875 CA2477199	281	L>V		No	ClinGen ExAC TOPMed gnomAD
rs754949575 CA2477198	282	G>E		No	ClinGen ExAC gnomAD
rs189008412 CA2477196	285	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353532916 COSM175314 rs1284442406	287	E>K	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA353532877 rs1244326310	292	Y>C		No	ClinGen TOPMed
rs764442493 CA2477193	293	N>S		No	ClinGen ExAC gnomAD
rs1364106735 CA353532861	294	A>D		No	ClinGen gnomAD
COSM1047978 rs763219166 COSM1047979 CA2477192	296	Q>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA353420679 rs1297749776	297	L>P		No	ClinGen TOPMed
rs767364303 CA2477176	299	N>S		No	ClinGen ExAC gnomAD
rs1459384007 CA353420639	303	Q>K		No	ClinGen gnomAD
rs752952903 CA2477174	305	A>D		No	ClinGen ExAC gnomAD
rs765406504 CA2477173	306	Q>R		No	ClinGen ExAC gnomAD
rs776727904 CA2477171	313	G>*		No	ClinGen ExAC gnomAD
CA2477169 COSM1047976 COSM1047977 rs761109512	314	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
COSM1425039 rs773569176 COSM1425038 CA2477168	314	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2477166 rs138272083	317	M>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2477167 rs772423610	317	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	319	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA75665212 rs764018019	320	Q>H		No	ClinGen Ensembl
rs1042386191 CA75665208	322	A>T		No	ClinGen Ensembl
CA2477165 rs773854261	322	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs900863254 CA75665188	323	R>T		No	ClinGen TOPMed
COSM1180203 CA2477146 rs768219996 COSM1180202	325	R>C	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA353420485 rs768219996	325	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2477145 rs762611876	325	R>H		No	ClinGen ExAC TOPMed gnomAD
CA353420462 rs1579636181	328	P>L		No	ClinGen Ensembl
CA2477144 rs774869379	328	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353420429 rs1171542781	333	K>T		No	ClinGen TOPMed gnomAD
CA75655698 rs961114706	334	E>Q		No	ClinGen TOPMed
TCGA novel	336	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1436419611 CA353420409	336	E>K		No	ClinGen gnomAD
rs746801653 CA2477139	338	M>I		No	ClinGen ExAC gnomAD
CA2477140 rs770947824	338	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1188760041 CA353420374	340	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353420377 rs1259767752	340	I>V		No	ClinGen gnomAD
TCGA novel	341	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2477138 rs777565349	344	K>T		No	ClinGen ExAC gnomAD
rs1393960968 CA353420325	348	N>D		No	ClinGen TOPMed
rs373248827 CA75655656	348	N>S		No	ClinGen TOPMed
rs373248827 CA353420322	348	N>T		No	ClinGen TOPMed
CA2477135 COSM3408853 COSM3408854 rs780167475	352	A>T	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	353	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1346264419 CA353420287	353	N>K		No	ClinGen TOPMed
rs750970158 CA2477133	353	N>S		No	ClinGen ExAC gnomAD
rs1347372556 CA353420261	357	M>L		No	ClinGen TOPMed gnomAD
rs1347372556 CA353420262	357	M>V		No	ClinGen TOPMed gnomAD
rs768044590 CA2477132	358	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs867439565 CA75655629	358	P>S		No	ClinGen Ensembl
rs1368904231 CA353420221	363	G>A		No	ClinGen TOPMed
CA2477129 rs764455169	363	G>R		No	ClinGen ExAC gnomAD
CA2477127 rs759661468	365	F>C		No	ClinGen ExAC gnomAD
CA353420209 rs1579633570	365	F>V		No	ClinGen Ensembl
CA2477125 rs759144701	368	Q>R		No	ClinGen ExAC gnomAD
CA2477124 rs776227927	372	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1214963810 CA353420159	372	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA353420161 rs776227927	372	R>S		No	ClinGen ExAC TOPMed gnomAD
CA353420154 rs1172635650	373	S>G		No	ClinGen gnomAD
TCGA novel	373	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353420136 rs1404177679	375	N>S		No	ClinGen gnomAD
rs746896565 CA2477122	376	A>V		No	ClinGen ExAC gnomAD
TCGA novel	377	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1287212322 CA353420124	377	S>Y		No	ClinGen Ensembl
rs771885497 CA2477120	378	I>F		No	ClinGen ExAC TOPMed gnomAD
rs771885497 CA353420120	378	I>L		No	ClinGen ExAC TOPMed gnomAD
CA2477119 rs200844222	379	I>V		No	ClinGen 1000Genomes ExAC
rs756290612 CA2477117	380	D>N		No	ClinGen ExAC gnomAD
rs1252763033 CA353420096	381	M>I		No	ClinGen gnomAD
CA353420099 rs1337056897	381	M>T		No	ClinGen TOPMed gnomAD
CA353420101 rs1180025713	381	M>V		No	ClinGen TOPMed
rs1563348476 CA353420088	382	G>D		No	ClinGen Ensembl
rs1218706119 CA353420092	382	G>R		No	ClinGen gnomAD
rs781194971 CA2477115	383	E>K		No	ClinGen ExAC
CA75655515 rs773906244	384	E>D		No	ClinGen Ensembl
rs1340803999 CA353420046	388	Q>P		No	ClinGen gnomAD
rs759206961 CA2477108	394	V>I		No	ClinGen ExAC gnomAD
rs146070021 CA2477106	395	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	396	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353419989 rs1298875350	397	S>Y		No	ClinGen TOPMed
CA2477103 rs141787208	399	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2477104 rs773180084	399	S>P		No	ClinGen ExAC gnomAD
rs768439289 CA2477082	403	V>I		No	ClinGen ExAC gnomAD
CA353419922 rs1301606575	405	M>I		No	ClinGen gnomAD
CA2477081 rs776799903	407	V>F		No	ClinGen ExAC TOPMed gnomAD
CA353419912 rs776799903	407	V>I		No	ClinGen ExAC TOPMed gnomAD
CA2477080 rs776799903	407	V>L		No	ClinGen ExAC TOPMed gnomAD
rs931924886 CA75652158	408	Q>R		No	ClinGen TOPMed
rs1388009859 CA353419888	411	K>E		No	ClinGen TOPMed
CA353419873 rs1318190842	413	L>*		No	ClinGen gnomAD
TCGA novel	413	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2477079 rs142795732	414	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1047973 CA2477078 COSM1047972 rs747130261	417	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs138611744 CA2477077	418	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs144979381 CA2477076	419	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1192606141 CA353419829	420	Y>C		No	ClinGen gnomAD
rs1395378894 CA353419810	423	M>V		No	ClinGen gnomAD
rs748659970 CA353419796	424	E>D		No	ClinGen ExAC gnomAD
rs1579510170 CA353419789	425	V>G		No	ClinGen Ensembl
CA353419780 rs1284155685	427	G>R		No	ClinGen TOPMed
COSM274362 rs1490900778 CA353419763 COSM274361	429	E>D	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA2477074 rs779476764	429	E>G		No	ClinGen ExAC gnomAD
rs1432561880 CA353024415	436	A>S		No	ClinGen TOPMed
TCGA novel	438	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	441	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2477070 rs146548123	442	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs146548123 CA2477071	442	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	445	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353012459 rs1302321582	446	Q>H		No	ClinGen gnomAD
CA353012436 rs1356353505	447	G>V		No	ClinGen TOPMed
CA75653692 rs1004590111	449	F>L		No	ClinGen TOPMed
rs745586265 CA2477033	452	T>I		No	ClinGen ExAC TOPMed gnomAD
rs745586265 CA2477032	452	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1316128633 CA353012292	453	H>Y		No	ClinGen TOPMed
rs1420154040 CA353012265	454	A>T		No	ClinGen gnomAD
CA353012211 rs531087753	457	A>G		No	ClinGen ExAC TOPMed gnomAD
CA353012221 rs887402738	457	A>S		No	ClinGen TOPMed gnomAD
CA75653670 rs887402738	457	A>T		No	ClinGen TOPMed gnomAD
CA2477029 rs531087753	457	A>V		No	ClinGen ExAC TOPMed gnomAD
CA353012206 rs1332137151	458	V>M		No	ClinGen Ensembl
rs1235935741 CA353012085	463	F>L		No	ClinGen TOPMed
CA2477028 rs367957940	465	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	467	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758393871 CA2477027	467	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	468	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	468	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200814072 CA75653621	469	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs753627499 CA353011977	471	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2477023 rs753627499	471	A>V		No	ClinGen ExAC gnomAD
rs147388715 CA353011883	479	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs147388715 COSM1318646 CA2477021 COSM1318647	479	R>Q	Variant assessed as Somatic; impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs370794609 CA2476999	482	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs140246088 CA2476996	486	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	490	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353010876 rs1194895026	492	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1259437739 CA353010842	493	E>G		No	ClinGen gnomAD
CA2476993 rs771713733	493	E>K		No	ClinGen ExAC gnomAD
rs771713733 CA2476994	493	E>Q		No	ClinGen ExAC gnomAD
rs1199134561 CA353010810	494	W>L		No	ClinGen gnomAD
CA353010743 rs1378690254	496	K>Q		No	ClinGen TOPMed
rs1446730517 CA353010651	498	T>I		No	ClinGen TOPMed
rs747633246 CA2476992	502	N>S		No	ClinGen ExAC gnomAD
rs749245429 CA2476989	505	D>G		No	ClinGen ExAC gnomAD
CA2476990 rs149527472	505	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2476987 rs755955069	506	Q>E		No	ClinGen ExAC
CA2476986 rs751875548	507	D>N		No	ClinGen ExAC gnomAD
rs866121744 CA75646940	508	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA2476984 rs758600665	509	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	510	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752720622 CA2476983	513	A>G		No	ClinGen ExAC gnomAD
CA2476981 COSM193715 COSM193714 rs760015455	515	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA353010023 rs1178708640	516	M>I		No	ClinGen TOPMed gnomAD
CA353010014 rs1467669027	517	D>Y		No	ClinGen gnomAD
CA353009975 rs1287611853	519	P>A		No	ClinGen gnomAD
TCGA novel	526	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353007765 rs1288369724	528	L>S		No	ClinGen gnomAD
rs1268756406 CA353007754	529	W>C		No	ClinGen TOPMed
rs1241189431 CA353007752	530	A>T		No	ClinGen gnomAD
rs750792310 CA353007745	531	I>F		No	ClinGen ExAC TOPMed gnomAD
rs750792310 CA2476958	531	I>V		No	ClinGen ExAC TOPMed gnomAD
CA75633790 rs567840502	532	G>S		No	ClinGen gnomAD
CA353007728 rs1159103031	533	K>N		No	ClinGen TOPMed
CA75633785 rs766976261	535	V>D		No	ClinGen Ensembl
rs1578016839 CA353007695	538	R>K		No	ClinGen Ensembl
CA353007681 rs1379604717	540	K>Q		No	ClinGen TOPMed
CA353007672 rs1290650427	541	K>E		No	ClinGen TOPMed gnomAD
CA353007563 rs1243332496	548	Q>R		No	ClinGen TOPMed gnomAD
TCGA novel	552	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770732308 CA2476931	553	T>P		No	ClinGen ExAC gnomAD
rs746841434 CA2476930	553	T>R		No	ClinGen ExAC gnomAD
CA353005502 rs1398849407	556	M>I		No	ClinGen gnomAD
CA353005506 rs1480606199	556	M>T		No	ClinGen gnomAD
CA2476928 rs768869284	556	M>V		No	ClinGen ExAC gnomAD
rs1328677012 CA353005474	558	S>G		No	ClinGen gnomAD
CA353005413 rs749507974	560	R>L		No	ClinGen ExAC TOPMed gnomAD
CA2476927 rs749507974	560	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1538364 CA75624278 COSM1538363 rs898296147	564	A>V	lung Variant assessed as Somatic; 0.0 impact. large_intestine urinary_tract [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA353005350 rs1403338805	565	E>D		No	ClinGen gnomAD
TCGA novel	574	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1562117969 CA353005161	575	Y>C		No	ClinGen Ensembl
CA353005074 rs1577745761	581	D>A		No	ClinGen Ensembl
rs751971326 CA2476921	581	D>E		No	ClinGen ExAC gnomAD
CA353005080 rs1439217349	581	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1221521130 CA353005057	582	P>L		No	ClinGen gnomAD
rs1252381555 CA353005071	582	P>T		No	ClinGen gnomAD
rs1292485646 CA353005027	583	Q>H		No	ClinGen gnomAD
rs1339684911 CA353024193	586	L>F		No	ClinGen TOPMed gnomAD
TCGA novel	590	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1269484388 CA353024143	590	R>L		No	ClinGen TOPMed
rs1279123677 CA353024132	591	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	593	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	595	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1465225996 CA353024054	597	K>R		No	ClinGen gnomAD
TCGA novel	600	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	602	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476883 rs747587522	606	S>I		No	ClinGen ExAC gnomAD
rs1159574074 CA353023944	606	S>R		No	ClinGen TOPMed
CA2476881 rs772655154	608	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353023861 rs1577601294	611	D>A		No	ClinGen Ensembl
CA2476879 rs779353219	611	D>E		No	ClinGen ExAC gnomAD
rs1456108074 CA353023848	612	R>H		No	ClinGen gnomAD
CA2476878 rs375750183	613	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA353023842 rs1577601075	613	I>V		No	ClinGen Ensembl
TCGA novel	615	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1263467757 CA353023808	615	W>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353023785 rs1361852892	617	Q>*		No	ClinGen gnomAD
CA353023786 rs1361852892	617	Q>E		No	ClinGen gnomAD
rs1316039255 CA353023767	618	A>D		No	ClinGen gnomAD
CA2476876 rs779665786	619	M>V		No	ClinGen ExAC gnomAD
CA75642074 rs906307436	621	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs755549772 CA2476875	623	T>K		No	ClinGen ExAC gnomAD
CA353023703 rs755549772	623	T>M		No	ClinGen ExAC gnomAD
CA353023696 rs1390720390	624	G>E		No	ClinGen gnomAD
TCGA novel CA2476873 rs767467805	624	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
CA353023689 rs1385728353	625	Q>*		No	ClinGen TOPMed
CA2476872 rs757132281	627	H>N		No	ClinGen ExAC gnomAD
CA75641997 CA2476871 rs576417700	627	H>Q		No	ClinGen ExAC gnomAD
TCGA novel	629	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763796407 CA2476870	630	V>M		No	ClinGen ExAC TOPMed gnomAD
rs776683516 CA2476868	632	P>L		No	ClinGen ExAC gnomAD
CA353023635 rs1450946935	633	T>A		No	ClinGen gnomAD
CA353023631 rs1265260594	633	T>I		No	ClinGen TOPMed gnomAD
rs372430600 CA2476867	634	Q>E		No	ClinGen ESP ExAC gnomAD
rs1490465817 CA353023620	635	V>D		No	ClinGen gnomAD
rs760690580 CA2476866	636	Q>R		No	ClinGen ExAC gnomAD
CA353023595 rs1562002082	639	N>D		No	ClinGen Ensembl
CA2476864 rs142524771	640	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA2476863 rs142524771	640	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1357195457 CA353023580	641	K>R		No	ClinGen TOPMed
CA2476862 rs529123568	642	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1562001322 CA353023555	645	V>L		No	ClinGen Ensembl
CA2476858 rs755744968	646	P>H		No	ClinGen ExAC TOPMed gnomAD
rs755744968 CA2476859	646	P>L		No	ClinGen ExAC TOPMed gnomAD
CA2476854 rs751489838	649	D>G		No	ClinGen ExAC gnomAD
rs757255213 CA2476855	649	D>N		No	ClinGen ExAC gnomAD
CA2476852 rs758155374	652	I>L		No	ClinGen ExAC
CA353023514 rs758155374	652	I>V		No	ClinGen ExAC
TCGA novel	657	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1015833872 CA75633664	657	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA2476830 rs778763864	662	K>R		No	ClinGen ExAC gnomAD
rs1168476602 CA353023129	663	H>R		No	ClinGen gnomAD
CA2476829 rs756461116	666	D>E		No	ClinGen ExAC gnomAD
CA2476828 rs750651093	670	S>A		No	ClinGen ExAC TOPMed gnomAD
COSM1197635 COSM1197634 rs1472586855 CA353023077	670	S>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs767746311 CA2476827	671	S>F		No	ClinGen ExAC gnomAD
CA2476826 rs762016527	672	N>D		No	ClinGen ExAC gnomAD
CA353023052 rs1461865777	674	C>F		No	ClinGen gnomAD
CA2476825 rs751611355	675	N>D		No	ClinGen ExAC gnomAD
CA2476824 rs764524930	675	N>S		No	ClinGen ExAC gnomAD
TCGA novel	678	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	678	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM4119747 rs376619081 CA2476821 COSM4119748	679	A>T	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA75633613 rs200179449	680	S>F		No	ClinGen Ensembl
rs371505343 CA75633607	683	E>D		No	ClinGen ESP TOPMed gnomAD
rs770518891 CA2476818	684	M>I		No	ClinGen ExAC TOPMed gnomAD
CA2476819 rs751279751	684	M>T		No	ClinGen ExAC gnomAD
rs759239403 CA2476820	684	M>V		No	ClinGen ExAC gnomAD
COSM480528 rs182039177 COSM480529 CA2476817	687	R>C	kidney Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA2476816 COSM1425034 rs573592664 COSM1425035	687	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1238177821 CA353022964	688	L>F		No	ClinGen gnomAD
CA353022935 rs1329663840	692	H>Y		No	ClinGen TOPMed
CA353022924 rs1445270474	693	R>S		No	ClinGen gnomAD
rs778622264 CA2476813	697	S>T		No	ClinGen ExAC gnomAD
TCGA novel	700	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs987619083 CA75632408	702	G>S		No	ClinGen TOPMed
CA353021994 rs1217277148	703	W>C		No	ClinGen gnomAD
rs760368296 CA2476796	709	V>E		No	ClinGen ExAC gnomAD
CA353021779 rs1347095955	711	V>A		No	ClinGen gnomAD
TCGA novel	713	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476791 rs768666285 COSM1425032 COSM1425033	717	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	717	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353021648 rs1455375755	718	R>*		No	ClinGen TOPMed gnomAD
CA353021646 rs1345515862	718	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1345866510 CA353021632	720	G>R		No	ClinGen gnomAD
rs1175909494 CA353021604	722	R>Q		No	ClinGen TOPMed gnomAD
CA2476790 rs749110612	724	C>Y		No	ClinGen ExAC gnomAD
CA75632314 rs924561165	728	L>F		No	ClinGen TOPMed gnomAD
CA353021506 rs1386786235	730	Y>S		No	ClinGen TOPMed gnomAD
TCGA novel	732	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476788 rs757623234	732	R>T		No	ClinGen ExAC gnomAD
CA2476786 rs777768926	733	D>E		No	ClinGen ExAC gnomAD
CA2476787 rs747244589	733	D>G		No	ClinGen ExAC gnomAD
rs1561773218 CA353021449	735	L>F		No	ClinGen Ensembl
COSM3714668 CA2476785 COSM3714669 rs758477480	737	R>W	ovary upper_aerodigestive_tract Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2476784 rs752667139	738	A>T		No	ClinGen ExAC gnomAD
rs1293617971 CA353021407	739	E>K		No	ClinGen gnomAD
CA2476781 rs142586678	742	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1188761103 CA353021335	744	I>V		No	ClinGen TOPMed gnomAD
rs1418278777 CA353021306	746	P>T		No	ClinGen TOPMed
rs766727839 CA2476780	751	Y>*		No	ClinGen ExAC gnomAD
CA353021220 rs1408917600	752	S>T		No	ClinGen gnomAD
CA2476778 rs772898935	759	H>R		No	ClinGen ExAC gnomAD
rs1161323815 CA353021057	764	R>K		No	ClinGen TOPMed
rs1460942463 CA353017370	765	P>S		No	ClinGen gnomAD
CA2476737 rs765236986	767	G>V		No	ClinGen ExAC gnomAD
rs1324648545 CA353017291	769	G>V		No	ClinGen gnomAD
rs759381698 CA2476736	773	V>F		No	ClinGen ExAC gnomAD
TCGA novel	775	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476735 rs776557778	776	K>Q		No	ClinGen ExAC gnomAD
rs770603309 CA2476734	776	K>R		No	ClinGen ExAC gnomAD
CA75624112 rs865887166	777	E>K		No	ClinGen Ensembl
CA2476733 rs774579772	778	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs374035152 CA2476730	778	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs374035152 CA2476731	778	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA2476732 rs774579772	778	R>S		No	ClinGen ExAC gnomAD
TCGA novel	779	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476729 rs148300961	781	E>A		No	ClinGen ESP ExAC gnomAD
CA2476728 rs142653808	783	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs746355673 CA2476727	783	K>R		No	ClinGen ExAC gnomAD
CA2476726 rs781648951	785	R>K		No	ClinGen ExAC gnomAD
CA2476724 CA2476725 rs751920649	785	R>S		No	ClinGen ExAC TOPMed gnomAD
CA353016991 COSM278442 COSM278441 rs1411500518	787	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs777596271 CA2476723	787	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1561549798 CA353016931	789	L>Q		No	ClinGen Ensembl
rs758071026 CA2476722	790	L>V		No	ClinGen ExAC gnomAD
rs1383473233 CA353016810	794	I>F		No	ClinGen gnomAD
rs35912235 CA2476721	795	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2476720 rs764651868	795	T>I		No	ClinGen ExAC TOPMed gnomAD
CA353016782 rs1202843167	796	H>R		No	ClinGen gnomAD
CA75624030 rs908397389	796	H>Y		No	ClinGen TOPMed gnomAD
rs1577092688 CA353015606	800	C>Y		No	ClinGen Ensembl
TCGA novel	803	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353015520 rs1256267990	804	G>D		No	ClinGen gnomAD
TCGA novel	804	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476699 rs766308486	805	R>Q		No	ClinGen ExAC gnomAD
rs1413396998 CA353015484	806	P>R		No	ClinGen gnomAD
CA2476698 rs755988090	806	P>S		No	ClinGen ExAC gnomAD
TCGA novel	807	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1296527864 CA353015443	808	G>A		No	ClinGen TOPMed
rs995827207 CA75623089	809	A>S		No	ClinGen TOPMed
CA353015362 rs1340040116	812	A>V		No	ClinGen TOPMed
CA2476697 rs750276180	813	T>I		No	ClinGen ExAC gnomAD
CA75623086 rs760619126	814	L>H		No	ClinGen ExAC gnomAD
TCGA novel	814	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476696 rs760619126	814	L>R		No	ClinGen ExAC gnomAD
rs1325640375 CA353015328	814	L>V		No	ClinGen TOPMed gnomAD
rs1280876995 CA353015284	817	L>S		No	ClinGen TOPMed
rs918859458 CA75622798	820	V>I		No	ClinGen Ensembl
CA75622782 rs974321249	822	M>K		No	ClinGen Ensembl
TCGA novel	824	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476681 rs756110830	825	I>M		No	ClinGen ExAC TOPMed gnomAD
CA353015011 rs1577086027	825	I>T		No	ClinGen Ensembl
CA2476680 rs750327475	828	P>L		No	ClinGen ExAC gnomAD
CA353014908 rs1561524593	831	Q>R		No	ClinGen Ensembl
CA2476677 rs751324960	832	E>D		No	ClinGen ExAC TOPMed gnomAD
rs765379258 CA2476676	833	E>D		No	ClinGen ExAC gnomAD
rs372013976 CA2476675	834	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2476674 rs567780877	835	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs13082830 CA75622731	837	V>D		No	ClinGen Ensembl
rs1425225580 CA353014739	838	I>F		No	ClinGen TOPMed
rs766539208 CA2476673	839	R>C		No	ClinGen ExAC gnomAD
COSM287401 rs184805711 COSM287402 CA2476672	839	R>H	ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA2476670 rs772669319	841	C>S		No	ClinGen ExAC gnomAD
rs1367477382 CA353014599	844	Q>*		No	ClinGen TOPMed
rs762089492 CA353014579 CA2476669	844	Q>H		No	ClinGen ExAC gnomAD
CA2476668 rs774721337	846	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353014527 rs1161100134	847	L>F		No	ClinGen gnomAD
rs149875451 CA75622692	848	V>L		No	ClinGen ESP TOPMed gnomAD
rs150724919 CA2476667	849	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs539731981 CA75622691	850	Y>C		No	ClinGen gnomAD
rs1172349398 CA353014426	851	S>C		No	ClinGen gnomAD
CA75622683 rs201178310	852	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2476663 rs201178310	852	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM3775318 CA2476664 rs779578391 COSM3775317	852	R>W	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	854	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781136889 CA2476661	855	E>D		No	ClinGen ExAC TOPMed gnomAD
CA2476662 rs201778092	855	E>K		No	ClinGen ExAC gnomAD
TCGA novel	856	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA75622665 rs755928119	860	E>K		No	ClinGen gnomAD
CA353012342 rs1561478809	862	N>D		No	ClinGen Ensembl
rs752081344 CA2476632	863	Q>E		No	ClinGen ExAC gnomAD
CA2476630 rs375222372	863	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA353012305 rs1387531420	863	Q>R		No	ClinGen TOPMed gnomAD
rs1014154638 CA353009222	868	N>K		No	ClinGen TOPMed
CA353009217 rs1372604239	869	V>L		No	ClinGen gnomAD
CA353009192 rs1312753756	870	G>D		No	ClinGen TOPMed
rs376024808 CA2476615	871	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA2476616 rs781177687 COSM3357744 COSM3357743	871	R>W	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1308896591 CA353009163	873	I>F		No	ClinGen gnomAD
CA2476614 rs139990093	873	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs199920092 CA2476612	874	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1202939215 CA353009146	874	T>P		No	ClinGen TOPMed
CA2476613 rs199920092	874	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2476611 rs753114055	876	A>V		No	ClinGen ExAC TOPMed gnomAD
CA353009085 rs1157369955	877	K>R		No	ClinGen gnomAD
TCGA novel	879	L>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	879	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	882	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1198254110 CA353009009	882	T>K		No	ClinGen gnomAD
CA75610641 rs201388081	884	R>C		No	ClinGen ExAC gnomAD
CA2476606 rs142613294	884	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA2476607 rs201388081	884	R>S		No	ClinGen ExAC gnomAD
CA2476605 rs371103619	886	A>V		No	ClinGen ESP ExAC gnomAD
rs772540253 CA2476604	888	L>P		No	ClinGen ExAC
rs1188614885 CA353008921	890	I>V		No	ClinGen TOPMed
rs1407850987 CA353008902	891	E>A		No	ClinGen TOPMed
COSM1047944 COSM1047943 rs1229955756 CA353008877	893	L>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA2476601 rs774327812	898	E>V		No	ClinGen ExAC gnomAD
rs748984742 CA2476599	899	H>N		No	ClinGen ExAC gnomAD
CA2476597 rs747123779	901	A>S		No	ClinGen ExAC TOPMed gnomAD
CA2476596 rs747123779	901	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1303853851 CA353007630	904	H>Y		No	ClinGen gnomAD
rs1387343262 CA353007618	905	V>A		No	ClinGen TOPMed
CA2476581 rs374261190	906	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA75606528 rs772245834	907	K>E		No	ClinGen Ensembl
rs1368360851 CA353007604	907	K>N		No	ClinGen TOPMed gnomAD
rs867944914 CA353007599	908	G>E		No	ClinGen TOPMed
CA75606522 rs867944914	908	G>V		No	ClinGen TOPMed
CA2476580 rs775085902	909	E>K		No	ClinGen ExAC gnomAD
rs180960336 CA75605664	910	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs180960336 CA2476560	910	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA2476559 rs773456732	911	F>L		No	ClinGen ExAC gnomAD
rs748244005 CA2476558	912	A>G		No	ClinGen ExAC TOPMed gnomAD
rs748244005 CA2476557	912	A>V		No	ClinGen ExAC TOPMed gnomAD
CA353006969 rs1330190217	915	S>*		No	ClinGen gnomAD
rs1561189321 CA353006963	916	D>N		No	ClinGen Ensembl
CA353006929 rs1576769251	918	M>T		No	ClinGen Ensembl
CA353006910 rs1320985340	919	V>A		No	ClinGen gnomAD
CA353006908 rs1388029743	920	E>K		No	ClinGen gnomAD
rs769272343 CA2476555	922	A>V		No	ClinGen ExAC gnomAD
rs746760146 COSM304381 CA2476553 COSM304382	924	T>M	large_intestine prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2476549 rs185042172	928	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs965276965 CA75605605	929	F>V		No	ClinGen gnomAD
TCGA novel	930	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1268592984 CA353006746	932	D>G		No	ClinGen gnomAD
rs373416442 CA75605598	932	D>N		No	ClinGen ESP gnomAD
TCGA novel	932	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1208668345 CA353006714	934	D>G		No	ClinGen gnomAD
rs1298303902 CA353006705	935	A>P		No	ClinGen TOPMed
CA2476547 rs763689385	935	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1405747544 CA353006687	936	A>G		No	ClinGen gnomAD
CA353006675 rs1209799795	938	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2476544 rs765183785	941	P>H		No	ClinGen ExAC TOPMed gnomAD
CA2476545 rs765183785	941	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767786545 CA2476541	947	S>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	948	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1296307647 CA353006540	948	F>V		No	ClinGen gnomAD
rs774456022 CA2476539	950	L>V		No	ClinGen ExAC gnomAD
rs1401717460 CA353006437	956	D>N		No	ClinGen TOPMed gnomAD
rs749339449 CA2476537	959	R>C		No	ClinGen ExAC TOPMed gnomAD
rs376315928 COSM1047939 COSM1047940 CA2476536	959	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs376315928 CA353006388	959	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs200922509 CA2476516	969	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA2476515 rs770261939	971	K>Q		No	ClinGen ExAC gnomAD
rs138691556 CA75604604	972	H>Y		No	ClinGen ESP TOPMed gnomAD
rs376296834 CA75604597	974	Q>E		No	ClinGen ESP TOPMed gnomAD
TCGA novel	974	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs376296834 CA353006219	974	Q>K		No	ClinGen ESP TOPMed gnomAD
CA2476513 rs777171428	974	Q>R		No	ClinGen ExAC gnomAD
CA353006207 CA2476512 rs771397571	975	D>E		No	ClinGen ExAC gnomAD
TCGA novel	978	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	982	V>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1339207966 CA353006167	982	V>L		No	ClinGen TOPMed
CA353006143 rs1265380864	985	V>A		No	ClinGen gnomAD
rs1384204860 CA353006130	987	L>P		No	ClinGen TOPMed
rs1036402798 CA75604583	989	E>D		No	ClinGen gnomAD
CA353006068 rs1165315843	992	I>T		No	ClinGen gnomAD
CA353006075 rs1224570625	992	I>V		No	ClinGen TOPMed gnomAD
CA353006020 rs1344769170	995	S>A		No	ClinGen gnomAD
rs771701556 CA2476509	999	G>S		No	ClinGen ExAC TOPMed gnomAD
CA75604576 rs144078102	999	G>V		No	ClinGen ESP TOPMed gnomAD
rs747672464 CA2476508	1002	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1232952891 CA353005906	1002	R>W		No	ClinGen gnomAD
rs778482031 CA2476507	1008	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1449775502 CA353005810 COSM1047936 COSM1047935	1008	V>I	endometrium Variant assessed as Somatic; 4.625e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs748759001 CA2476486	1010	S>G		No	ClinGen ExAC gnomAD
CA2476485 rs751130300	1010	S>I		No	ClinGen ExAC gnomAD
CA353022634 rs1404985212	1012	T>S		No	ClinGen gnomAD
CA75658011 rs1019142663	1013	S>G		No	ClinGen TOPMed
CA2476482 rs77008736	1017	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2476483 rs77008736	1017	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs999789507 CA75657972	1018	V>M		No	ClinGen TOPMed
CA353022482 rs1426654805	1021	P>T		No	ClinGen gnomAD
rs1470971454 CA353022463	1022	N>D		No	ClinGen gnomAD
rs752937730 CA2476480	1022	N>I		No	ClinGen ExAC TOPMed gnomAD
CA353022438 rs1368078937	1023	V>L		No	ClinGen TOPMed
CA2476476 rs753914427	1028	V>I		No	ClinGen ExAC gnomAD
rs1486075591 CA353022326	1029	P>S		No	ClinGen gnomAD
rs1261475586 CA353022282	1032	P>T		No	ClinGen gnomAD
CA2476474 rs761244804	1036	P>L		No	ClinGen ExAC gnomAD
CA75657907 rs868827229	1036	P>S		No	ClinGen gnomAD
CA353022194 rs868827229	1036	P>T		No	ClinGen gnomAD
CA2476472 rs767902686	1037	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353022125 rs1296047822	1040	P>S		No	ClinGen gnomAD
CA353022105 rs1363072804	1041	Q>*		No	ClinGen gnomAD
CA2476471 rs762036394	1042	M>I		No	ClinGen ExAC gnomAD
TCGA novel	1042	M>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1302697663 CA353022082	1042	M>V		No	ClinGen gnomAD
CA353022005 rs1360587095	1045	F>L		No	ClinGen gnomAD
CA2476470 rs373178609	1046	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2476468 rs748808363	1047	A>T		No	ClinGen ExAC TOPMed gnomAD
CA2476467 rs774966536	1047	A>V		No	ClinGen ExAC TOPMed gnomAD
CA75657840 COSM446959 rs916748914	1048	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1179943976 CA353021894	1050	W>G		No	ClinGen gnomAD
rs1409825299 CA353021859	1051	M>V		No	ClinGen Ensembl
TCGA novel	1053	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780894973 CA2476464	1054	I>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs757094635 CA2476463	1054	I>T		No	ClinGen ExAC gnomAD
rs779293996 CA2476461	1055	Y>C		No	ClinGen ExAC gnomAD
rs746738362 CA2476462	1055	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA353021723 rs1308638231	1057	A>T		No	ClinGen gnomAD
CA2476459 rs375576173 COSM3940616	1057	A>V	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	1058	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1073	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM193675 rs147087123 COSM273629 CA2476432	1073	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA353020421 rs1208565255	1076	T>N		No	ClinGen gnomAD
rs577817819 CA2476430	1078	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA353020343 rs1274166986	1078	I>V		No	ClinGen gnomAD
CA353020323 rs1380591245	1079	R>Q		No	ClinGen gnomAD
CA353020280 rs148430862	1080	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1326587557 CA353020284	1080	D>G		No	ClinGen TOPMed gnomAD
rs1326587557 CA353020282	1080	D>V		No	ClinGen TOPMed gnomAD
CA353020265 rs1239061728	1081	L>V		No	ClinGen TOPMed gnomAD
CA2476428 rs775993860	1082	H>R		No	ClinGen ExAC gnomAD
TCGA novel	1083	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1298638581 CA353020174	1085	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2476427 rs770971642	1087	E>D		No	ClinGen ExAC gnomAD
rs1157689950 CA353019996	1090	K>E		No	ClinGen TOPMed gnomAD
CA2476426 rs760662640	1095	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1034439787 CA75654694	1099	M>T		No	ClinGen TOPMed
rs868478167 CA75654671	1102	D>G		No	ClinGen Ensembl
TCGA novel	1102	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773195036 CA2476425	1103	M>V		No	ClinGen ExAC TOPMed gnomAD
CA2476423 rs747913353	1105	E>K		No	ClinGen ExAC TOPMed gnomAD
rs746365672 CA75654651	1107	C>Y		No	ClinGen Ensembl
CA353019440 rs1454556060	1109	K>I		No	ClinGen gnomAD
CA353019442 rs1454556060	1109	K>R		No	ClinGen gnomAD
CA353019443 rs1454556060	1109	K>T		No	ClinGen gnomAD
CA2476404 rs149931152	1113	I>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781377421 CA2476403	1114	A>S		No	ClinGen ExAC TOPMed gnomAD
rs781377421 CA2476402	1114	A>T		No	ClinGen ExAC TOPMed gnomAD
CA2476401 rs771021661	1118	K>E		No	ClinGen ExAC gnomAD
rs151301388 COSM1425026 CA2476400 COSM1425027	1122	T>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA75650996 rs201181624	1124	R>*		No	ClinGen gnomAD
rs778256058 CA2476399	1124	R>P		No	ClinGen ExAC TOPMed gnomAD
COSM3427826 rs778256058 COSM3427825 CA353018515	1124	R>Q	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM1692940 COSM1692939 CA2476397 rs748581222	1129	R>*	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs367714345 CA2476396	1129	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs753456107 CA2476394	1132	Q>P		No	ClinGen ExAC gnomAD
CA353018404 rs753456107	1132	Q>R		No	ClinGen ExAC gnomAD
rs766019189 CA2476393	1133	S>P		No	ClinGen ExAC gnomAD
TCGA novel	1134	I>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1416638600 CA353018379	1134	I>T		No	ClinGen gnomAD
CA2476392 rs199647496	1134	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA353018365 rs1313557880	1135	C>Y		No	ClinGen gnomAD
CA2476391 rs534391982	1138	F>C		No	ClinGen 1000Genomes ExAC gnomAD
rs112585082 CA2476390	1138	F>L		No	ClinGen ExAC gnomAD
CA2476389 rs761834820	1140	V>I		No	ClinGen ExAC gnomAD
CA353018249 rs1400604418	1141	M>L		No	ClinGen TOPMed
rs763771626 CA2476387	1142	V>I		No	ClinGen ExAC gnomAD
CA353018163 rs1415134254	1144	A>G		No	ClinGen gnomAD
TCGA novel	1147	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1148	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1250386400 CA353018056	1149	T>K		No	ClinGen TOPMed gnomAD
rs1201886217 CA353017968	1154	M>T		No	ClinGen gnomAD
CA2476384 rs368477906	1155	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed
rs1003757145 CA75650833	1155	E>V		No	ClinGen Ensembl
rs376363470 CA2476383	1156	M>K		No	ClinGen ESP ExAC TOPMed
rs376363470 CA2476382	1156	M>T		No	ClinGen ESP ExAC TOPMed
CA353017902 rs1439442118	1157	G>D		No	ClinGen gnomAD
CA353017892 rs1208950713	1158	Q>*		No	ClinGen gnomAD
rs1208950713 CA353017896	1158	Q>K		No	ClinGen gnomAD
rs779428191	1159	E>=	Variant assessed as Somatic; 0.0005061 impact. [NCI-TCGA]	No	NCI-TCGA
CA2476380 rs748581967	1159	E>K	Variant assessed as Somatic; 0.002762 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1211756666 CA353016367	1161	Q>P		No	ClinGen gnomAD
rs1250163102 CA353016329	1162	Y>C		No	ClinGen gnomAD
TCGA novel	1164	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV000660540 rs1553773676	1165	K>*		No	ClinVar dbSNP
CA2476313 rs774478977 COSM731758 COSM731759	1166	I>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2476312 rs200712817	1167	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs776043383 CA2476310	1168	E>A		No	ClinGen ExAC gnomAD
CA2476309 rs770301757	1169	L>V		No	ClinGen ExAC gnomAD
CA2476308 rs746190980	1170	I>T		No	ClinGen ExAC gnomAD
TCGA novel	1172	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1394198286 CA353015989	1173	T>S		No	ClinGen gnomAD
CA2476305 rs746556427	1175	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1439113081 CA353015939	1175	K>T		No	ClinGen TOPMed
TCGA novel	1176	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476304 rs777331057	1177	M>K		No	ClinGen ExAC gnomAD
CA353015851 rs1311883660	1178	I>K		No	ClinGen TOPMed
rs1162606599 CA353015857	1178	I>V		No	ClinGen gnomAD
CA353015811 rs1420304514	1181	L>F		No	ClinGen gnomAD
CA353015802 rs1448126960	1182	V>A		No	ClinGen TOPMed gnomAD
rs770554516	1185	F>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA2476288 rs777122141	1185	F>L		No	ClinGen ExAC gnomAD
rs574220713 CA2476286	1186	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772693397 CA2476285	1188	I>V		No	ClinGen ExAC gnomAD
CA353015631 rs1346971953	1190	E>D		No	ClinGen gnomAD
CA353015591 rs1443081345	1192	V>M		No	ClinGen gnomAD
CA353015481 rs1158576022	1198	R>I		No	ClinGen Ensembl
COSM731761 COSM731760 rs902090459 CA75643081	1201	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM1047923 COSM1047924 CA75643053 rs761920713	1208	F>L	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	1209	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754901644 CA2476281	1209	L>P		No	ClinGen ExAC gnomAD
rs940378954 CA75643045	1211	F>L		No	ClinGen Ensembl
TCGA novel	1216	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2476257 rs144155979	1218	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2476255 rs755590141	1221	D>A		No	ClinGen ExAC gnomAD
CA353008184 rs1576043808	1224	K>N		No	ClinGen Ensembl
CA75619524 rs757765489	1224	K>Q		No	ClinGen TOPMed
rs774846596 CA2476211	1225	P>H		No	ClinGen ExAC gnomAD
CA2476209 rs566247034	1226	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs201724714 CA75619493	1228	D>E		No	ClinGen ExAC
CA2476206 rs771045473	1229	V>L		No	ClinGen ExAC TOPMed gnomAD
CA2476207 rs771045473	1229	V>M		No	ClinGen ExAC TOPMed gnomAD
rs779293832 CA2476205	1231	D>N		No	ClinGen ExAC gnomAD
rs1238715963 CA353008084	1232	A>T	Variant assessed as Somatic; 0.0001387 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs749452981 CA2476203	1236	F>S		No	ClinGen ExAC gnomAD
CA2476201 rs756697221	1237	V>I		No	ClinGen ExAC TOPMed
COSM1642332 CA353008007 rs1188476583 COSM1642333	1238	R>C	stomach [Cosmic]	No	ClinGen cosmic curated TOPMed
CA353007999 rs1256556991	1238	R>L		No	ClinGen gnomAD
CA353007958 rs1254707213	1241	Q>L		No	ClinGen gnomAD
rs750918281 CA2476200	1244	L>V		No	ClinGen ExAC gnomAD
CA353007912 rs1190512729	1245	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA353007910 rs1190512729	1245	R>L		No	ClinGen TOPMed
rs781637391 CA2476199	1246	D>N		No	ClinGen ExAC gnomAD
rs1390894524 CA353007875	1248	V>A		No	ClinGen TOPMed
rs751860249 CA2476197	1248	V>F		No	ClinGen ExAC TOPMed gnomAD
rs751860249 CA75619357	1248	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1475353469 CA353007843	1252	M>I		No	ClinGen TOPMed
rs763791039 CA2476196	1252	M>T		No	ClinGen ExAC gnomAD
CA2476195 rs762508377	1254	I>T		No	ClinGen ExAC gnomAD
CA353007789 rs1234264719	1259	D>E		No	ClinGen gnomAD
rs747437965 CA2476174	1261	W>R		No	ClinGen ExAC gnomAD
TCGA novel	1262	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353023411 rs1216926669	1263	N>H		No	ClinGen gnomAD
rs1311812728 CA353023407	1263	N>S		No	ClinGen gnomAD
rs199626657 CA2476173	1264	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353023403 rs199626657	1264	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1377205076 CA353023401	1264	S>T		No	ClinGen gnomAD
rs1176471383 CA353023384	1266	M>I		No	ClinGen gnomAD
rs558289554 CA2476172	1268	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752313498 CA2476171	1271	T>A		No	ClinGen ExAC gnomAD
rs764902930 CA2476170	1272	W>*		No	ClinGen ExAC gnomAD
rs754461043 CA2476169	1274	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs150776949 CA75629343	1275	D>E		No	ClinGen ESP
TCGA novel	1275	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA75629321 rs566731837	1276	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353023314 rs1258318088	1277	M>K		No	ClinGen gnomAD
CA75629317 rs992421878	1278	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1307255630 CA353023276	1282	H>R		No	ClinGen gnomAD
CA2476165 rs773193357	1283	I>V		No	ClinGen ExAC gnomAD
rs767242642 CA2476164	1284	Y>F		No	ClinGen ExAC gnomAD
rs1349647484 CA353023256	1285	Q>P		No	ClinGen TOPMed
rs761631358 CA2476163	1287	K>I		No	ClinGen ExAC gnomAD
CA2476162 rs775583072	1288	T>I		No	ClinGen ExAC TOPMed gnomAD
rs201703105 CA75629272	1292	M>I		No	ClinGen 1000Genomes
rs1211434629 CA353022836	1297	Y>N		No	ClinGen TOPMed gnomAD
TCGA novel	1300	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141301525 CA2476131 COSM1047921 COSM1047922	1301	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed
CA2476130 COSM446955 rs755694732 COSM446956	1301	R>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	1306	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1311396812 CA353022706	1307	D>Y		No	ClinGen TOPMed gnomAD
CA2476125 rs763926479	1309	T>I		No	ClinGen ExAC TOPMed gnomAD
CA2476126 rs763926479	1309	T>S		No	ClinGen ExAC TOPMed gnomAD
CA2476127 rs757210914	1309	T>S		No	ClinGen ExAC gnomAD
CA75626931 rs902143375	1314	T>N		No	ClinGen Ensembl
CA75626926 rs376832211	1315	Y>C		No	ClinGen ESP TOPMed gnomAD
rs754090010 CA2476123	1315	Y>H		No	ClinGen ExAC gnomAD
rs148752175 CA2476122	1317	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353022498 rs1575521833	1318	I>T		No	ClinGen Ensembl
CA2476119 COSM1738918 COSM1738919 rs772497329	1319	R>Q	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs773337761 CA2476120	1319	R>W		No	ClinGen ExAC gnomAD
CA353022470 rs1575521698	1320	N>T		No	ClinGen Ensembl
COSM1047919 CA353022451 COSM1047920 rs1192160113	1321	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA353022392 rs1575521539	1324	V>G		No	ClinGen Ensembl
CA353022312 rs1267652273	1329	A>S		No	ClinGen gnomAD
rs774675078 CA2476117	1330	S>L		No	ClinGen ExAC gnomAD
CA2476116 rs769177137	1334	G>A		No	ClinGen ExAC gnomAD
CA353022214 rs1487780014	1334	G>S		No	ClinGen gnomAD
rs1248327845 CA353022182	1336	G>V		No	ClinGen Ensembl
CA2476115 rs749601515	1339	G>D		No	ClinGen ExAC gnomAD
CA75626866 rs1039388242	1340	I>N		No	ClinGen Ensembl
CA353022122 rs1235187285	1340	I>V		No	ClinGen gnomAD
TCGA novel	1341	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs944534060 CA75626858	1344	D>N		No	ClinGen Ensembl
CA2476112 rs554950742	1346	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353021938 rs1381906896	1347	E>K		No	ClinGen gnomAD
rs780719627 CA353021869	1349	D>E		No	ClinGen ExAC TOPMed gnomAD
COSM231942 COSM231943 CA2476110 rs147103435	1350	E>K	oesophagus skin Variant assessed as Somatic; 4.622e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA353021830 rs1375376847	1351	E>K		No	ClinGen gnomAD
rs768330044 CA75626826	1352	D>G		No	ClinGen Ensembl
CA2476108 rs777645997	1353	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1191982427 CA353021753	1354	D>Q		No	ClinGen gnomAD

No associated diseases with Q9ULU8

4 regional properties for Q9ULU8

Type	Name	Position	InterPro Accession
domain	C2 domain	380 - 495	IPR000008
domain	Pleckstrin homology domain	521 - 626	IPR001849
domain	MUN domain	835 - 1300	IPR010439
domain	Munc13 homology 1	931 - 1111	IPR014770

Functions

		Description
EC Number
Subcellular Localization	Synapse Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane ; Peripheral membrane protein	Membrane-associated to vesicles Strongly enriched in synaptic fractions Preferentially binds to dense core vesicles but not to synaptic vesicles Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3 Probably localizes to different vesicles compared to CADPS2
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
neuronal dense core vesicle membrane	The lipid bilayer surrounding a neuronal dense core vesicle.
presynapse	The part of a synapse that is part of the presynaptic cell.

3 GO annotations of molecular function

Name	Definition
lipid binding	Binding to a lipid.
metal ion binding	Binding to a metal ion.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

5 GO annotations of biological process

Name	Definition
dense core granule exocytosis	The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
positive regulation of exocytosis	Any process that activates or increases the frequency, rate or extent of exocytosis.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
synaptic vesicle exocytosis	Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8BYR5	Cadps2	Calcium-dependent secretion activator 2	Mus musculus (Mouse)	PR
Q80TJ1	Cadps	Calcium-dependent secretion activator 1	Mus musculus (Mouse)	PR
Q62717	Cadps	Calcium-dependent secretion activator 1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MLDPSSSEEE	SDEIVEEESG	KEVLGSAPSG	ARLSPSRTSE	GSAGSAGLGG	GGAGAGAGVG
70	80	90	100	110	120
AGGGGGSGAS	SGGGAGGLQP	SSRAGGGRPS	SPSPSVVSEK	EKEELERLQK	EEEERKKRLQ
130	140	150	160	170	180
LYVFVMRCIA	YPFNAKQPTD	MARRQQKISK	QQLQTVKDRF	QAFLNGETQI	MADEAFMNAV
190	200	210	220	230	240
QSYYEVFLKS	DRVARMVQSG	GCSANDSREV	FKKHIEKRVR	SLPEIDGLSK	ETVLSSWMAK
250	260	270	280	290	300
FDAIYRGEED	PRKQQARMTA	SAASELILSK	EQLYEMFQNI	LGIKKFEHQL	LYNACQLDNP
310	320	330	340	350	360
DEQAAQIRRE	LDGRLQMADQ	IARERKFPKF	VSKEMENMYI	EELKSSVNLL	MANLESMPVS
370	380	390	400	410	420
KGGEFKLQKL	KRSHNASIID	MGEESENQLS	KSDVVLSFSL	EVVIMEVQGL	KSLAPNRIVY
430	440	450	460	470	480
CTMEVEGGEK	LQTDQAEASK	PTWGTQGDFS	TTHALPAVKV	KLFTESTGVL	ALEDKELGRV
490	500	510	520	530	540
ILHPTPNSPK	QSEWHKMTVS	KNCPDQDLKI	KLAVRMDKPQ	NMKHSGYLWA	IGKNVWKRWK
550	560	570	580	590	600
KRFFVLVQVS	QYTFAMCSYR	EKKAEPQELL	QLDGYTVDYT	DPQPGLEGGR	AFFNAVKEGD
610	620	630	640	650	660
TVIFASDDEQ	DRILWVQAMY	RATGQSHKPV	PPTQVQKLNA	KGGNVPQLDA	PISQFYADRA
670	680	690	700	710	720
QKHGMDEFIS	SNPCNFDHAS	LFEMVQRLTL	DHRLNDSYSC	LGWFSPGQVF	VLDEYCARNG
730	740	750	760	770	780
VRGCHRHLCY	LRDLLERAEN	GAMIDPTLLH	YSFAFCASHV	HGNRPDGIGT	VTVEEKERFE
790	800	810	820	830	840
EIKERLRVLL	ENQITHFRYC	FPFGRPEGAL	KATLSLLERV	LMKDIVTPVP	QEEVKTVIRK
850	860	870	880	890	900
CLEQAALVNY	SRLSEYAKIE	ENQKDAENVG	RLITPAKKLE	DTIRLAELVI	EVLQQNEEHH
910	920	930	940	950	960
AEPHVDKGEA	FAWWSDLMVE	HAETFLSLFA	VDMDAALEVQ	PPDTWDSFPL	FQLLNDFLRT
970	980	990	1000	1010	1020
DYNLCNGKFH	KHLQDLFAPL	VVRYVDLMES	SIAQSIHRGF	ERESWEPVKS	LTSNLPNVNL
1030	1040	1050	1060	1070	1080
PNVNLPKVPN	LPVNIPLGIP	QMPTFSAPSW	MAAIYDADNG	SGTSEDLFWK	LDALQTFIRD
1090	1100	1110	1120	1130	1140
LHWPEEEFGK	HLEQRLKLMA	SDMIESCVKR	TRIAFEVKLQ	KTSRSTDFRV	PQSICTMFNV
1150	1160	1170	1180	1190	1200
MVDAKAQSTK	LCSMEMGQEH	QYHSKIDELI	EETVKEMITL	LVAKFVTILE	GVLAKLSRYD
1210	1220	1230	1240	1250	1260
EGTLFSSFLS	FTVKAASKYV	DVPKPGMDVA	DAYVTFVRHS	QDVLRDKVNE	EMYIERLFDQ
1270	1280	1290	1300	1310	1320
WYNSSMNVIC	TWLTDRMDLQ	LHIYQLKTLI	RMVKKTYRDF	RLQGVLDSTL	NSKTYETIRN
1330	1340	1350
RLTVEEATAS	VSEGGGLQGI	SMKDSDEEDE	EDD