Q80TJ1
PR
Gene name |
Cadps (Caps, Caps1, Kiaa1121) |
Protein name |
Calcium-dependent secretion activator 1 |
Names |
Calcium-dependent activator protein for secretion 1, CAPS-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:27062 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80TJ1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80TJ1-F1 | Predicted | AlphaFoldDB |
59 variants for Q80TJ1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs214998741 | 19 | R>S | No | EVA | |
| rs3389321433 | 219 | S>I | No | EVA | |
| rs3389303435 | 266 | L>M | No | EVA | |
| rs3389314346 | 270 | Q>* | No | EVA | |
| rs3404372411 | 293 | C>* | No | EVA | |
| rs3389308829 | 370 | R>H | No | EVA | |
| rs3389308896 | 378 | D>V | No | EVA | |
| rs3389316708 | 378 | D>Y | No | EVA | |
| rs3404795852 | 404 | E>G | No | EVA | |
| rs3389314351 | 426 | G>R | No | EVA | |
| rs3389279684 | 465 | T>S | No | EVA | |
| rs3389272756 | 475 | L>V | No | EVA | |
| rs3389316661 | 529 | I>N | No | EVA | |
| rs3389306788 | 560 | K>R | No | EVA | |
| rs3389233958 | 567 | L>I | No | EVA | |
| rs3389263212 | 569 | Q>* | No | EVA | |
| rs3389308852 | 616 | A>D | No | EVA | |
| rs3389305811 | 620 | A>V | No | EVA | |
| rs3404804893 | 637 | N>I | No | EVA | |
| rs3404796053 | 639 | K>M | No | EVA | |
| rs3404585124 | 639 | K>N | No | EVA | |
| rs3404973911 | 639 | K>Q | No | EVA | |
| rs3389305723 | 645 | Q>H | No | EVA | |
| rs3389308894 | 652 | Q>* | No | EVA | |
| rs3389308893 | 701 | S>T | No | EVA | |
| rs3404585150 | 703 | L>Q | No | EVA | |
| rs3389319272 | 770 | I>F | No | EVA | |
| rs1133518419 | 808 | P>R | No | EVA | |
| rs3389314318 | 821 | R>W | No | EVA | |
| rs3389303392 | 832 | P>S | No | EVA | |
| rs3389279656 | 850 | V>A | No | EVA | |
| rs3404974820 | 851 | N>I | No | EVA | |
| rs3389289656 | 854 | R>P | No | EVA | |
| rs3389314322 | 857 | E>D | No | EVA | |
| rs3389303396 | 884 | T>K | No | EVA | |
| rs3389279704 | 899 | E>G | No | EVA | |
| rs3389279720 | 902 | H>Y | No | EVA | |
| rs3389306864 | 926 | T>R | No | EVA | |
| rs3389306816 | 942 | Q>L | No | EVA | |
| rs3389306879 | 959 | F>V | No | EVA | |
| rs3389303480 | 974 | H>Y | No | EVA | |
| rs3389263270 | 1006 | S>T | No | EVA | |
| rs3389308860 | 1010 | V>I | No | EVA | |
| rs3389289682 | 1011 | K>E | No | EVA | |
| rs3389308621 | 1016 | N>D | No | EVA | |
| rs3404886246 | 1042 | P>R | No | EVA | |
| rs3389303458 | 1114 | R>M | No | EVA | |
| rs3389279671 | 1115 | I>N | No | EVA | |
| rs3389279660 | 1125 | S>N | No | EVA | |
| rs3389308814 | 1174 | E>D | No | EVA | |
| rs3389319282 | 1189 | T>I | No | EVA | |
| rs3389308666 | 1189 | T>S | No | EVA | |
| rs3389263241 | 1194 | V>I | No | EVA | |
| rs3389308670 | 1214 | T>R | No | EVA | |
| rs3389279687 | 1227 | P>T | No | EVA | |
| rs3412971959 | 1248 | D>E | No | EVA | |
| rs3389263208 | 1276 | T>I | No | EVA | |
| rs3389308638 | 1334 | S>DG* | No | EVA | |
| rs3389321403 | 1337 | G>R | No | EVA |
No associated diseases with Q80TJ1
7 regional properties for Q80TJ1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Oxidoreductase FAD/NAD(P)-binding | 168 - 274 | IPR001433 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 108 - 115 | IPR001709-1 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 167 - 186 | IPR001709-2 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 205 - 216 | IPR001709-3 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 260 - 268 | IPR001709-4 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | 61 - 158 | IPR008333 |
| domain | FAD-binding domain, ferredoxin reductase-type | 56 - 159 | IPR017927 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| dense core granule | Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. |
| extrinsic component of neuronal dense core vesicle membrane | The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| catecholamine secretion | The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| positive regulation of calcium ion-dependent exocytosis | Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. |
| positive regulation of exocytosis | Any process that activates or increases the frequency, rate or extent of exocytosis. |
| presynaptic dense core vesicle exocytosis | The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| synaptic vesicle priming | A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. |
| vesicle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLDPSSSEEE | SDEILEEERG | KDVLGSAASG | ARLSPSRTSE | GSAGSAGMGG | SGAGAGVGAG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGGGSGASSG | GGAGGLQPSS | RAGGGRPSSP | SPSVVSEKEK | EELERLQKEE | EERKKRLQLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VFVMRCIAYP | FNAKQPTDMA | RRQQKISKQQ | LQTVKDRFQA | FLNGETQIVA | DEAFMNAVQS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YYEVFLKSDR | VARMVQSGGC | SANDSREVFK | KHIEKRVRSL | PEIDGLSKET | VLSSWMAKFD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AIYRGEEDPR | KQQARMTASA | ASELILSKEQ | LYEMFQNILG | IKKFEHQLLY | NACQLDNPDE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QAAQIRRELD | GRLQMADQIA | RERKFPKFVS | KEMENMYIEE | LKSSVNLLMA | NLESMPVSKG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GEFKLQKLKR | SHNASIIDMG | EESENQLSKS | DVLLSFSLEV | VIMEVQGLKS | LAPNRIVYCT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MEVEGGEKLQ | TDQAEASKPT | WGTQGDFSTT | HALPAVKVKL | FTESTGVLAL | EDKELGRVIL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HPTPNSPKQS | EWHKMTVSKN | CPDQDLKIKL | AVRMDKPQNM | KHSGYLWTIG | KNVWKRWKKR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FFVLVQVSQY | TFAMCSYREK | KAEPQELLQL | DGYTVDYTDP | QPGLEGGRAF | FNAVKEGDTV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IFASDDEQDR | ILWVQAMYRA | TGQSHKPVPP | TQVQKLNAKG | GNVPQLDAPI | SQFSGLKDAD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RAQKHGMDEF | ISSNPCNFDH | ASLFEMVQRL | TLDHRLNDSY | SCLGWFSPGQ | VFVLDEYCAR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NGVRGCHRHL | CYLRDLLERA | ENGAMIDPTL | LHYSFAFCAS | HVHGNRPDGI | GTVTVEEKER |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FEEIKERLRV | LLENQITHFR | YCFPFGRPEG | ALKATLSLLE | RVLMKDIVTP | VPQEEVKTVI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RKCLEQAALV | NYSRLSEYAK | IEENQKDAEN | VGRLITPAKK | LEDTIRLAEL | VIEVLQQNEE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HHAEPHVDKG | EAFAWWSDLM | VEHAETFLSL | FAVDMDAALE | VQPPDTWDSF | PLFQLLNDFL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RTDYNLCNGK | FHKHLQDLFA | PLVVRYVDLM | ESSIAQSIHR | GFERESWEPV | KSLTSNLPNV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| NLPNVNLPKV | PNLPVNIPLG | IPQMPTFSAP | SWMAAIYDAD | NGSGTSEDLF | WKLDALQTFI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RDLHWPEEEF | GKHLEQRLKL | MASDMIESCV | KRTRIAFEVK | LQKTSRSTDF | RVPQSICTMF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| NVMVDAKAQS | TKLCSMEMGQ | EHQYHSKIDE | LIEETVKEMI | TLLVAKFVTI | LEGVLAKLSR |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| YDEGTLFSSF | LSFTVKAASK | YVDVPKPGMD | VADAYVTFVR | HSQDVLRDKV | NEEMYIERLF |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| DQWYNSSMNI | ICTWLTDRMD | LQLHIYQLKT | LIRMVKKTYR | DFRLQGVLDS | TLNSKTYETI |
| 1330 | 1340 | 1350 | |||
| RNRLTVEEAT | ASVSEGGGLQ | GISMKDSDEE | DEEDD |