Q62717

PR
Gene name
Cadps (Caps, Caps1)
Protein name
Calcium-dependent secretion activator 1
Names
Calcium-dependent activator protein for secretion 1, CAPS-1, rCAPS
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:26989
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q62717

Entry ID Method Resolution Chain Position Source
6A68 X-ray 290 A A 859-1036 PDB
7VS3 X-ray 260 A A 391-634 PDB
AF-Q62717-F1 Predicted AlphaFoldDB

No variants for Q62717

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q62717

No associated diseases with Q62717

5 regional properties for Q62717

Type Name Position InterPro Accession
domain TolB, N-terminal 22 - 128 IPR007195
repeat WD40-like beta propeller 242 - 271 IPR011659-1
repeat WD40-like beta propeller 282 - 316 IPR011659-2
repeat WD40-like beta propeller 325 - 349 IPR011659-3
repeat WD40-like beta propeller 377 - 400 IPR011659-4

Functions

Description
EC Number
Subcellular Localization
  • Synapse
  • Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane ; Peripheral membrane protein
  • Membrane-associated to vesicles
  • Strongly enriched in synaptic fractions
  • Preferentially binds to dense core vesicles but not to synaptic vesicles
  • Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3
  • Probably localizes to different vesicles compared to CADPS2
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
dense core granule Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.
extrinsic component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
presynapse The part of a synapse that is part of the presynaptic cell.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
phosphatidylinositol-4,5-bisphosphate binding Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

10 GO annotations of biological process

Name Definition
catecholamine secretion The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
positive regulation of calcium ion-dependent exocytosis Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.
positive regulation of exocytosis Any process that activates or increases the frequency, rate or extent of exocytosis.
presynaptic dense core vesicle exocytosis The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulated exocytosis A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
synaptic vesicle priming A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9ULU8 CADPS Calcium-dependent secretion activator 1 Homo sapiens (Human) PR
Q8BYR5 Cadps2 Calcium-dependent secretion activator 2 Mus musculus (Mouse) PR
Q80TJ1 Cadps Calcium-dependent secretion activator 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MLDPSSSEEE SDEILEEESG KEVLGSAASG ARLSPSRTNE GSAGSAGMGG SGAGAGVGAG
70 80 90 100 110 120
GGGGSGASSG GGAGGLQPSS RAGGGRPSSP SPSVVSEKEK EELERLQKEE EERKKRLQLY
130 140 150 160 170 180
VFVMRCIAYP FNAKQPTDMA RRPRKISKQQ LQTVKDRFQA FLNGETQIVA DEAFMNAVQS
190 200 210 220 230 240
YYEVFLKSDR VARMVQSGGC SANDSREVFK KHIEKRVRSL PEIDGLSKET VLSSWMAKFD
250 260 270 280 290 300
AIYRGEEDPR KQQARMTASA ASELILSKEQ LYEMFQNILG IKKFEHQLLY NACQLDNPDE
310 320 330 340 350 360
QAAQIRRELD GRLQMADQIA RERKFPKFVS KEMENMYIEE LKSSVNLLMA NLESMPVSKG
370 380 390 400 410 420
GEFKLQKLKR SHNASIIDMG EESENQLSKS DVLLSFSLEV VIMEVQGLKS LAPNRIVYCT
430 440 450 460 470 480
MEVEGGEKLQ TDQAEASKPT WGTQGDFSTT HALPAVKVKL FTESTGVLAL EDKELGRVIL
490 500 510 520 530 540
HPTPNSPKQS EWHKMTVSKN CPDQDLKIKL AVRMDKPQNM KHSGYLWTIG KNVWKRWKKR
550 560 570 580 590 600
FFVLVQVSQY TFAMCSYREK KAEPQELLQL DGYTVDYTDP QPGLEGGRAF FNAVKEGDTV
610 620 630 640 650 660
IFASDDEQDR ILWVQAMYRA TGQSHKPVPP TQVQKLKPRA ETCLSMDAPI SQFYADRAQK
670 680 690 700 710 720
HGMDEFISSN PCNFDHASLF EMVQRLTLDH RLNDSYSCLG WFSPGQVFVL DEYCARNGVR
730 740 750 760 770 780
GCHRHLCYLR DLLERAENGA MIDPTLLHYS FAFCASHVHG NRPDGIGTVT VEEKERFEEI
790 800 810 820 830 840
KERLRVLLEN QITHFRYCFP FGRPEGALKA TLSLLERVLM KDIVTPVPQE EVKTVIRKCL
850 860 870 880 890 900
EQAALVNYSR LSEYAKIEEN VGRLITPAKK LEDTIRLAEL VIEVLQQNEE HHAEAFAWWS
910 920 930 940 950 960
DLMVEHAETF LSLFAVDMDA ALEVQPPDTW DSFPLFQLLN DFLRTDYNLC NGKFHKHLQD
970 980 990 1000 1010 1020
LFAPLVVRYV DLMESSIAQS IHRGFERESW EPVNNGSGTS EDLFWKLDAL QTFIRDLHWP
1030 1040 1050 1060 1070 1080
EEEFGKHLEQ RLKLMASDMI ESCVKRTRIA FEVKLQKTSR STDFRVPQSI CTMFNVMVDA
1090 1100 1110 1120 1130 1140
KAQSTKLCSM EMGQEHQYHS KIDELIEETV KEMITLLVAK FVTILEGVLA KLSRYDEGTL
1150 1160 1170 1180 1190 1200
FSSFLSFTVK AASKYVDVPK PGMDVADAYV TFVRHSQDVL RDKVNEEMYI ERLFDQWYNS
1210 1220 1230 1240 1250 1260
SMNVICTWLT DRMDLQLHIY QLKTLIRMVK KTYRDFRLQG VLDSTLNSKT YETIRNRLTV
1270 1280
EERTASVSEG GGLQGISMKD SDEEDEEDD