Q8BYR5

PR
Gene name
Cadps2 (Caps2)
Protein name
Calcium-dependent secretion activator 2
Names
Calcium-dependent activator protein for secretion 2, CAPS-2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:320405
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

26-99 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BYR5

Entry ID Method Resolution Chain Position Source
AF-Q8BYR5-F1 Predicted AlphaFoldDB

No variants for Q8BYR5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8BYR5

No associated diseases with Q8BYR5

4 regional properties for Q8BYR5

Type Name Position InterPro Accession
domain C2 domain 353 - 468 IPR000008
domain Pleckstrin homology domain 491 - 596 IPR001849
domain MUN domain 801 - 1246 IPR010439
domain Munc13 homology 1 886 - 1057 IPR014770

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Synapse
  • Membrane-associated to vesicles
  • Strongly enriched in synaptic fractions
  • Probably localizes to different vesicles compared to CADPS
  • Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
parallel fiber to Purkinje cell synapse An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
presynapse The part of a synapse that is part of the presynaptic cell.
presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.

2 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.
metal ion binding Binding to a metal ion.

7 GO annotations of biological process

Name Definition
cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
dense core granule exocytosis The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
hematopoietic stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.
positive regulation of exocytosis Any process that activates or increases the frequency, rate or extent of exocytosis.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
synaptic vesicle priming A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9ULU8 CADPS Calcium-dependent secretion activator 1 Homo sapiens (Human) PR
Q80TJ1 Cadps Calcium-dependent secretion activator 1 Mus musculus (Mouse) PR
Q62717 Cadps Calcium-dependent secretion activator 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MLDPSSSEEE SDEGLEEESR EVLVAPGVSQ RAPPAAAREG RRDAPGRSGG GSGGGAARPV
70 80 90 100 110 120
SPSPSVLSEG RNEPELQLDE EQERRIRLQL YVFVVRCIAY PFNAKQPTDM ARRQQKLNKQ
130 140 150 160 170 180
QLQLLKERFQ AFLNGETQIV ADEAFCNAVR SYYEVFLKSD RVARMVQSGG CSANDFREVF
190 200 210 220 230 240
KKNIEKRVRS LPEIDGLSKE TVLSSWIAKY DAIYRGEEDL CKQPNRMTLS AVSELILSKE
250 260 270 280 290 300
QLYEMFQQIL GIKKLEHQLL YNACQLDNAD EQAAQIRREL DGRLQLAEKM AKERRFPRFI
310 320 330 340 350 360
SKEMESMYIE ELRASVNLLM ANLESLPVSK GGPEFKLQKL KRSQNSAFLD LGDENEIQLS
370 380 390 400 410 420
KSDVVLSFTL EIVIMEVQGL KSVAPNRIVY CTMEVEGGEK LQTDQAEASR PQWGTQGDFN
430 440 450 460 470 480
TTHPRPVVKV KLFTESTGVL ALEDKELGRV VLYPTSNSSK SAELHRMTVP KNSQDSDLKI
490 500 510 520 530 540
KLAVRMDKPA HMKHSGYLYA LGQKVWKRWK KRYFVLVQVS QYTFAMCSYR EKKSEPQELM
550 560 570 580 590 600
QLEGYTVDYT DPHPGLQGGQ VFFNAVKEGD TVIFASDDEQ DRILWVQAMY RATGQSYKPV
610 620 630 640 650 660
PAVQSQKLNP KGGALHADAQ LYADRFQKHG MDEFISASPC KLDHAFLFRI LQRQTLDHRL
670 680 690 700 710 720
NDSYSCLGWF SPGQVFVLDE YCARYGVRGC HRHLCYLTEL MEHSENGAVI DPTLLHYSFA
730 740 750 760 770 780
FCASHVHGNR PDGIGTVSVE EKERFEEIKD RLSSLLENQI SHFRYCFPFG RPEGALKATL
790 800 810 820 830 840
SLLERVLMKD IATPIPAEEV KKVVRKCLEK AALINYTRLT EYAKIEETMN QATPARKLEE
850 860 870 880 890 900
VLHLAELCIE VLQQNEEHHA EGREAFAWWP DLLAEHAEKF WALFTVDMDT ALEAQPQDSW
910 920 930 940 950 960
DSFPLFQLLN NFLRNDTLLC NGKFHKHLQE IFVPLVVRYV DLMESAIAQS IHRGFEQETW
970 980 990 1000 1010 1020
QPVKNIANSL PNVALPKVPS LPLNLPQIPS FSTPPWMASL YESTNGSTTS EDLFWKLDAL
1030 1040 1050 1060 1070 1080
QMFVFDLHWP EQEFAHHLEQ RLKLMASDMI EACVKRTRTA FELKLQKANK TTDLRIPASV
1090 1100 1110 1120 1130 1140
CTMFNVLVDA KKQSTKLCAL DGGQEQQYHS KIDDLIDNTV KEIIALLVSK FVSVLEGVLS
1150 1160 1170 1180 1190 1200
KLSRYDEGTF FSSILSFTVK AAAKYVDVPK PGMDLADTYI MFVRQNQDIL REKVNEEMYI
1210 1220 1230 1240 1250 1260
EKLFDQWYSN SMKVICVWLA DRLDLQLHIY QLKTLIKIVK KTYRDFRLQG VLEGTLNSKT
1270 1280 1290
YDTLHRRLTV EEATASVSEG GGLQGITMKD SDEEEEG