AiPD: Autoinhibited Protein Database

Q9UHA3

Gene name	RSL24D1 (C15orf15, RPL24L, My024)
Protein name	Probable ribosome biogenesis protein RLP24
Names	Ribosomal L24 domain-containing protein 1, Ribosomal protein L24-like
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51187
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

35-163 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

35-163 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

38 structures for Q9UHA3

Entry ID	Method	Resolution	Chain	Position	Source
6LSS	EM	323 A	7	1-163	PDB
6LU8	EM	313 A	7	1-163	PDB
8FKP	EM	285 A	SV	1-163	PDB
8FKQ	EM	276 A	SV	1-163	PDB
8FKR	EM	289 A	SV	1-163	PDB
8FKS	EM	288 A	SV	1-163	PDB
8FKT	EM	281 A	SV	1-163	PDB
8FKU	EM	282 A	SV	1-163	PDB
8FKV	EM	247 A	SV	1-163	PDB
8FKW	EM	250 A	SV	1-163	PDB
8FKX	EM	259 A	SV	1-163	PDB
8FKY	EM	267 A	SV	1-163	PDB
8FKZ	EM	304 A	SV	1-163	PDB
8FL0	EM	291 A	SV	1-163	PDB
8FL2	EM	267 A	SV	1-163	PDB
8FL3	EM	253 A	SV	1-163	PDB
8FL4	EM	289 A	SV	1-163	PDB
8FL6	EM	262 A	SV	1-163	PDB
8FL7	EM	255 A	SV	1-163	PDB
8FL9	EM	275 A	SV	1-163	PDB
8FLA	EM	263 A	SV	1-163	PDB
8FLB	EM	255 A	SV	1-163	PDB
8FLC	EM	276 A	SV	1-163	PDB
8FLD	EM	258 A	SV	1-163	PDB
8FLE	EM	248 A	SV	1-163	PDB
8FLF	EM	265 A	SV	1-163	PDB
8IDT	EM	280 A	7	1-163	PDB
8IDY	EM	300 A	7	1-163	PDB
8IE3	EM	330 A	7	1-163	PDB
8INE	EM	320 A	7	1-163	PDB
8INF	EM	300 A	7	1-163	PDB
8INK	EM	320 A	7	1-163	PDB
8IPD	EM	320 A	7	1-163	PDB
8IPX	EM	430 A	7	1-163	PDB
8IPY	EM	320 A	7	1-163	PDB
8IR1	EM	330 A	7	1-163	PDB
8IR3	EM	350 A	7	1-163	PDB
AF-Q9UHA3-F1	Predicted				AlphaFoldDB

144 variants for Q9UHA3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262768278 CA392781648	3	I>M		No	ClinGen gnomAD
CA7573482 rs777526919	4	E>G		No	ClinGen ExAC gnomAD
CA7573483 rs777526919	4	E>V		No	ClinGen ExAC gnomAD
CA7573481 rs756569215	7	Y>C		No	ClinGen ExAC gnomAD
CA392781607 rs1218707788	9	C>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs11540394 CA271241097	12	P>L		No	ClinGen Ensembl
TCGA novel	12	P>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA271241098 rs1003962483	12	P>S		No	ClinGen Ensembl
CA271241095 rs11540389	13	I>N		No	ClinGen Ensembl
rs371629101 CA271241096	13	I>V		No	ClinGen ESP TOPMed gnomAD
CA7573478 rs755577679	14	Y>C		No	ClinGen ExAC gnomAD
rs755577679 CA392781577	14	Y>F		No	ClinGen ExAC gnomAD
CA7573477 rs751998821	15	P>L		No	ClinGen ExAC TOPMed gnomAD
CA271241094 rs199532636	15	P>S		No	ClinGen 1000Genomes TOPMed
rs766496104 CA392781567	16	G>A		No	ClinGen ExAC gnomAD
CA7573476 rs766496104	16	G>E		No	ClinGen ExAC gnomAD
CA392781558 rs762878339	17	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1278504670 CA392781556	18	G>C		No	ClinGen TOPMed
rs765399239 CA271241093 CA7573473	19	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1173400339 CA392781547	19	M>T		No	ClinGen gnomAD
CA392781541 rs1178439610	20	M>T		No	ClinGen gnomAD
rs761988262 CA7573472	20	M>V		No	ClinGen ExAC gnomAD
rs775326760 CA7573471	21	F>V		No	ClinGen ExAC gnomAD
CA392781529 rs1262414457	22	V>I		No	ClinGen TOPMed
CA7573468 rs774087440	25	D>N		No	ClinGen ExAC gnomAD
rs200023487 CA7573440	28	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA271240616 rs17856255	29	F>I		No	ClinGen ExAC gnomAD
CA392781386 rs957387047	29	F>L		No	ClinGen gnomAD
rs17856255 CA7573439	29	F>V		No	ClinGen ExAC gnomAD
CA271240614 rs17851202	30	R>G		No	ClinGen TOPMed
CA271240613 rs111669877	30	R>T		No	ClinGen Ensembl
rs778975431 CA7573438	37	H>R		No	ClinGen ExAC TOPMed gnomAD
CA271240612 rs939879035	37	H>Y		No	ClinGen TOPMed
CA7573437 rs757258993	38	K>N		No	ClinGen ExAC gnomAD
CA392781308 rs1367145063	40	F>C		No	ClinGen TOPMed
CA392781312 rs1347090778	40	F>L		No	ClinGen gnomAD
TCGA novel	42	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA271240610 rs11540381	42	K>R		No	ClinGen Ensembl
rs11540393 CA271240608	43	K>N		No	ClinGen Ensembl
rs754119174 CA7573436	44	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM191447 CA7573434 rs572620938	44	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs572620938 CA392781280	44	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA271240607 rs17852590	45	N>D		No	ClinGen Ensembl
CA7573433 rs772105282	45	N>S		No	ClinGen ExAC TOPMed gnomAD
CA392781265 rs1290751382	47	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA392781263 rs1464589332	47	R>H		No	ClinGen gnomAD
CA392781252 rs751351733	49	V>F		No	ClinGen ExAC TOPMed gnomAD
CA7573432 rs751351733	49	V>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	53	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1421858666 CA392781216	54	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1467469744 CA392781213	54	A>V		No	ClinGen TOPMed
CA7573431 rs766272809	58	A>S		No	ClinGen ExAC TOPMed gnomAD
rs368924119 CA7573429	59	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368924119 CA7573430	59	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1478045216 CA392781182	60	G>S		No	ClinGen TOPMed
rs1261974696 CA392781149	64	T>I		No	ClinGen TOPMed gnomAD
CA392781145 rs1405220959	65	V>E		No	ClinGen TOPMed
rs1459562317 CA392781146	65	V>L		No	ClinGen gnomAD
TCGA novel	65	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7573386 rs759167715	66	D>V		No	ClinGen ExAC gnomAD
CA392781111 rs1310796598	68	S>*		No	ClinGen TOPMed
rs1338047570 CA392781114	68	S>P		No	ClinGen gnomAD
CA7573385 rs774755801	69	F>L		No	ClinGen ExAC TOPMed gnomAD
CA7573383 rs763374116	74	R>C		No	ClinGen ExAC gnomAD
rs145555296 CA7573382	74	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs145555296 CA392781068	74	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	74	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA271240432 rs1006463257	76	N>D		No	ClinGen TOPMed
CA7573381 rs769784566	76	N>S		No	ClinGen ExAC gnomAD
CA7573380 rs370157846	77	E>A		No	ClinGen ESP ExAC gnomAD
rs781386911 CA7573379	79	I>V		No	ClinGen ExAC TOPMed gnomAD
rs200616324 CA271240430	80	K>R		No	ClinGen gnomAD
CA7573378 rs769044549	82	Q>E		No	ClinGen ExAC gnomAD
CA392781014 rs1197069200	82	Q>H		No	ClinGen gnomAD
rs968465281 CA271240429	83	R>Q		No	ClinGen TOPMed
CA7573377 rs747216897	84	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA271240428 rs17851390	86	W>R		No	ClinGen Ensembl
rs778860442 CA7573376	87	N>H		No	ClinGen ExAC gnomAD
TCGA novel	87	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7573351 rs754427012	91	D>G		No	ClinGen ExAC gnomAD
rs144437295 CA7573349	92	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	94	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750846016 CA7573347	96	V>I		No	ClinGen ExAC TOPMed gnomAD
rs371062419 CA271239766	98	E>D		No	ClinGen TOPMed gnomAD
CA271239764 rs145320361	99	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA7573344 rs777224422	101	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs764295201 CA7573343	101	Q>H		No	ClinGen ExAC gnomAD
CA392780862 rs1462183225	103	R>C		No	ClinGen gnomAD
rs199758477 CA7573342	103	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs775403419 CA7573341	104	Q>H		No	ClinGen ExAC gnomAD
CA271239763 rs113933212	104	Q>R		No	ClinGen gnomAD
CA392780853 rs1470001086	105	A>T		No	ClinGen TOPMed gnomAD
CA271239762 rs968911646	107	F>L		No	ClinGen Ensembl
rs772387456 CA7573340	109	M>I		No	ClinGen ExAC TOPMed gnomAD
CA7573339 rs746065826 CA392780811	110	N>K		No	ClinGen ExAC gnomAD
CA7573321 rs774377773	115	N>T		No	ClinGen ExAC gnomAD
CA392780740 rs1209852668	119	Q>K		No	ClinGen Ensembl
rs1057218932 CA271239541	120	K>E		No	ClinGen TOPMed gnomAD
rs1425383291 CA392780724	121	V>I		No	ClinGen gnomAD
rs942533265 CA271239540	122	Q>E		No	ClinGen gnomAD
CA392780708 rs1157012792	123	D>G		No	ClinGen gnomAD
rs746905564 CA7573316	126	E>V		No	ClinGen ExAC gnomAD
CA271239538 rs139024218	132	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs911162056 CA271239539	132	H>N		No	ClinGen gnomAD
CA7573315 rs139024218	132	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7573314 rs757777074	133	L>F		No	ClinGen ExAC gnomAD
rs200024314 COSM309606 CA7573313	134	I>L	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs200024314 CA271239537	134	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7573311 rs150727724	135	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1224212817 CA392780626	136	A>T		No	ClinGen TOPMed
CA7573310 rs754306199	136	A>V		No	ClinGen ExAC TOPMed gnomAD
CA392780613 rs1327774181	138	L>F		No	ClinGen TOPMed
CA392780604 rs1316315609	139	A>V		No	ClinGen gnomAD
rs1458479049 CA392780589	140	G>A		No	ClinGen TOPMed
rs1177662303 CA392780576	142	G>E		No	ClinGen gnomAD
CA392780560 rs1191844668	144	Q>H		No	ClinGen TOPMed gnomAD
rs756376298 CA7573286	144	Q>R		No	ClinGen ExAC gnomAD
CA7573285 rs200847511	146	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA271239413 rs17852589	146	E>G		No	ClinGen gnomAD
TCGA novel	146	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392780551 rs1371882795	146	E>Q		No	ClinGen TOPMed
COSM1373604 CA7573284 rs781511293	147	E>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA7573283 rs751183994	148	K>E		No	ClinGen ExAC gnomAD
rs1192808150 CA392780522	150	V>I		No	ClinGen TOPMed gnomAD
CA7573280 rs766430929	151	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA392780506 rs763224716	152	Q>P		No	ClinGen ExAC gnomAD
rs763224716 CA7573279	152	Q>R		No	ClinGen ExAC gnomAD
rs1249849823 CA392780494	154	Q>E		No	ClinGen gnomAD
rs1249849823 CA392780495	154	Q>K		No	ClinGen gnomAD
CA7573278 rs750572411	155	E>D		No	ClinGen ExAC gnomAD
CA392780482 rs1312479906	155	E>G		No	ClinGen TOPMed
CA392780476 rs1348518536	156	D>G		No	ClinGen gnomAD
rs1212669184 CA392780480	156	D>N		No	ClinGen gnomAD
CA7573277 rs763887148	157	V>M		No	ClinGen ExAC gnomAD
CA7573276 rs760350791	158	D>E		No	ClinGen ExAC gnomAD
rs1299964957 CA392780464	158	D>G		No	ClinGen gnomAD
CA7573275 rs775329023	159	M>T		No	ClinGen ExAC gnomAD
rs1358016739 CA392780459	159	M>V		No	ClinGen TOPMed
rs771954608 CA7573274	160	E>A		No	ClinGen ExAC gnomAD
rs369049485 CA7573273	161	D>V		No	ClinGen ESP ExAC gnomAD
rs774073894 CA7573272	162	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7573271 rs770500399	164	P>K		No	ClinGen ExAC gnomAD
CA271239411 rs770500399	164	P>Q		No	ClinGen ExAC gnomAD

No associated diseases with Q9UHA3

2 regional properties for Q9UHA3

Type	Name	Position	InterPro Accession
domain	RsgA GTPase domain	102 - 279	IPR010914
domain	Circularly permuted (CP)-type guanine nucleotide-binding (G) domain	114 - 276	IPR030378

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
ribosome	An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.

1 GO annotations of molecular function

Name	Definition
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

2 GO annotations of biological process

Name	Definition
ribosomal large subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q07915	RLP24	Ribosome biogenesis protein RLP24	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q3SZ12	RSL24D1	Probable ribosome biogenesis protein RLP24	Bos taurus (Bovine)	PR
Q99L28	Rsl24d1	Probable ribosome biogenesis protein RLP24	Mus musculus (Mouse)	PR
Q6P6G7	Rsl24d1	Probable ribosome biogenesis protein RLP24	Rattus norvegicus (Rat)	PR
Q17606	rpl-24.2	Probable ribosome biogenesis protein RLP24	Caenorhabditis elegans	PR
Q7ZTZ2	rsl24d1	Probable ribosome biogenesis protein RLP24	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MRIEKCYFCS	GPIYPGHGMM	FVRNDCKVFR	FCKSKCHKNF	KKKRNPRKVR	WTKAFRKAAG
70	80	90	100	110	120
KELTVDNSFE	FEKRRNEPIK	YQRELWNKTI	DAMKRVEEIK	QKRQAKFIMN	RLKKNKELQK
130	140	150	160
VQDIKEVKQN	IHLIRAPLAG	KGKQLEEKMV	QQLQEDVDME	DAP