Q3SZ12
Gene name |
RSL24D1 |
Protein name |
Probable ribosome biogenesis protein RLP24 |
Names |
Ribosomal L24 domain-containing protein 1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:783948 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3SZ12
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3SZ12-F1 | Predicted | AlphaFoldDB |
23 variants for Q3SZ12
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs475147653 | 3 | I>V | No | EVA | |
| rs440519165 | 6 | C>G | No | EVA | |
| rs454150878 | 6 | C>W | No | EVA | |
| rs470977906 | 11 | G>R | No | EVA | |
| rs439970683 | 14 | Y>S | No | EVA | |
| rs463270676 | 17 | H>Q | No | EVA | |
| rs442224817 | 21 | F>L | No | EVA | |
| rs483323034 | 21 | F>L | No | EVA | |
| rs435321930 | 29 | F>V | No | EVA | |
| rs455439955 | 34 | S>T | No | EVA | |
| rs440865662 | 46 | P>T | No | EVA | |
| rs451250635 | 48 | K>E | No | EVA | |
| rs471709057 | 51 | W>C | No | EVA | |
| rs443490917 | 54 | A>V | No | EVA | |
| rs459381246 | 55 | F>Y | No | EVA | |
| rs463565531 | 57 | K>I | No | EVA | |
| rs480439454 | 60 | G>C | No | EVA | |
| rs442536992 | 62 | E>K | No | EVA | |
| rs454970981 | 66 | D>V | No | EVA | |
| rs459444485 | 68 | S>* | No | EVA | |
| rs434051716 | 131 | I>S | No | EVA | |
| rs470968657 | 136 | A>D | No | EVA | |
| rs433506781 | 137 | P>T | No | EVA |
No associated diseases with Q3SZ12
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| ribosome | An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| ribosomal large subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. |
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07915 | RLP24 | Ribosome biogenesis protein RLP24 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9UHA3 | RSL24D1 | Probable ribosome biogenesis protein RLP24 | Homo sapiens (Human) | PR |
| Q99L28 | Rsl24d1 | Probable ribosome biogenesis protein RLP24 | Mus musculus (Mouse) | PR |
| Q6P6G7 | Rsl24d1 | Probable ribosome biogenesis protein RLP24 | Rattus norvegicus (Rat) | PR |
| Q17606 | rpl-24.2 | Probable ribosome biogenesis protein RLP24 | Caenorhabditis elegans | PR |
| Q7ZTZ2 | rsl24d1 | Probable ribosome biogenesis protein RLP24 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRIEKCYFCS | GPIYPGHGMM | FVRNDCKVFR | FCKSKCHKNF | KKKRNPRKVR | WTKAFRKAAG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KELTVDNSFE | FEKRRNEPVK | YQRELWNKTI | DAMKRVEEIK | QKRQAKFIMN | RLKKNKELQK |
| 130 | 140 | 150 | 160 | ||
| VQDVKEVKQN | IHLIRAPLAG | KGKQLEDKMV | QKLQEDVDME | DVS |