AiPD: Autoinhibited Protein Database

Q9UH62

Gene name	ARMCX3 (ALEX3, BM-017, UNQ2517/PRO6007)
Protein name	Armadillo repeat-containing X-linked protein 3
Names	ARM protein lost in epithelial cancers on chromosome X 3, Protein ALEX3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51566
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-94 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

25-94 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UH62

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UH62-F1	Predicted				AlphaFoldDB

169 variants for Q9UH62

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1257173965 CA414033613	4	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA10474066 rs200151007	4	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1556038240 CA414033660	7	V>I		No	ClinGen gnomAD
rs1486916934 CA414033693	9	W>R		No	ClinGen TOPMed
CA414033760 rs1556038249	12	A>G		No	ClinGen TOPMed
CA414033797 rs1214514335	15	V>M		No	ClinGen TOPMed
rs1556038252 CA414033827	16	I>T		No	ClinGen gnomAD
rs782282127 CA10474067	16	I>V		No	ClinGen ExAC TOPMed gnomAD
rs782394011 CA10474068	18	A>T		No	ClinGen ExAC gnomAD
CA10474069 rs782636138	18	A>V		No	ClinGen ExAC gnomAD
CA414033853 rs1230999634	20	A>S		No	ClinGen TOPMed
TCGA novel	23	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10474071 rs782347784	26	R>K		No	ClinGen ExAC gnomAD
rs1354592095 CA414033911	28	T>S		No	ClinGen TOPMed
TCGA novel	32	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1293632584 CA414033953	34	N>S		No	ClinGen TOPMed
rs1416582945 CA414033969	36	E>A		No	ClinGen TOPMed
rs1569370235 CA414033995	39	A>S		No	ClinGen Ensembl
rs782644531 CA10474072	45	D>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs138397719 CA10474073	46	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA414034038 rs138397719	46	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA10474075 rs782415759	49	A>G		No	ClinGen ExAC gnomAD
rs1453222109 CA414034080	52	C>R		No	ClinGen TOPMed
rs868935240 CA414034081	52	C>S		No	ClinGen TOPMed
CA333873607 rs868935240	52	C>Y		No	ClinGen TOPMed
CA10474077 rs781998690	59	D>G		No	ClinGen ExAC gnomAD
TCGA novel	60	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414034158 rs1556038328	63	D>N		No	ClinGen gnomAD
CA414034162 rs1189144991	63	D>V		No	ClinGen TOPMed gnomAD
TCGA novel	64	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414034174 rs1425900337	65	D>N		No	ClinGen TOPMed
TCGA novel	66	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782110371 CA10474079	66	D>E		No	ClinGen ExAC
CA10474080 rs782741127	67	S>G		No	ClinGen ExAC gnomAD
rs1603241641 CA414034197	68	N>D		No	ClinGen Ensembl
TCGA novel	69	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA333873609 rs112014657	70	S>G		No	ClinGen Ensembl
rs781820213 CA10474081	73	I>T		No	ClinGen ExAC gnomAD
CA414034248 rs1556038354	75	W>R		No	ClinGen gnomAD
CA414034272 rs1485910186	78	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	80	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10474083 rs782696028	80	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1211468081 CA414034290	81	R>W		No	ClinGen TOPMed
CA414034298 rs1556038362	82	I>T		No	ClinGen gnomAD
CA10474084 rs781909195	82	I>V		No	ClinGen ExAC gnomAD
TCGA novel	84	T>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414034316 rs1569370348	85	E>A		No	ClinGen Ensembl
CA414034326 rs1333658285	86	A>V		No	ClinGen TOPMed
rs782535499 CA10474085	88	T>A		No	ClinGen ExAC gnomAD
TCGA novel	91	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1556038374 CA414034371	93	R>S		No	ClinGen gnomAD
CA333873611 rs1041715655	100	R>L		No	ClinGen TOPMed gnomAD
CA414034411 rs1041715655	100	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA10474087 rs781854858	100	R>W		No	ClinGen ExAC gnomAD
rs1556038386 CA414034421	102	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA414034426 rs1234962087	103	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10474088 rs782490463	109	A>V		No	ClinGen ExAC gnomAD
TCGA novel	114	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA333873612 rs903185505	117	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs375844900 CA10474091	120	P>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs375844900 CA414034537	120	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1556038412 CA414034549	122	E>*		No	ClinGen Ensembl
CA10474092 rs149266795	125	K>M		No	ClinGen ESP ExAC gnomAD
CA414034571 rs149266795	125	K>T		No	ClinGen ESP ExAC gnomAD
CA414034606 rs1556038418	130	V>A		No	ClinGen gnomAD
CA10474093 rs782258566	132	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1556038433 CA414034668	139	L>V		No	ClinGen gnomAD
TCGA novel	142	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1556038442 CA414034730	148	N>K		No	ClinGen gnomAD
COSM1682775 rs781963129 CA10474095	151	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
TCGA novel	152	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1459826307 CA414034795	157	D>E		No	ClinGen TOPMed
rs868995472 CA414034812	160	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA333873613 rs1033127729	161	D>H		No	ClinGen Ensembl
rs1371626978 CA414034820	161	D>V		No	ClinGen TOPMed gnomAD
rs1556038455 CA414034853	167	I>V		No	ClinGen gnomAD
CA414034859 rs1170372682	168	V>I		No	ClinGen TOPMed gnomAD
CA414034892 rs1556038462	173	N>D		No	ClinGen gnomAD
CA414034894 rs1556038462	173	N>H		No	ClinGen gnomAD
rs1429574589 CA414034896	173	N>S		No	ClinGen TOPMed
rs369113898 CA10474096	174	T>I		No	ClinGen ESP ExAC gnomAD
rs1556038479 CA414034978	185	I>T		No	ClinGen gnomAD
TCGA novel	188	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10474099 rs372051555	198	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA333873615 rs372051555	198	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1556038494 CA414035087	201	K>E		No	ClinGen gnomAD
CA414035108 rs1556038511	204	M>L		No	ClinGen gnomAD
CA414035126 rs1603241709	206	Q>E		No	ClinGen Ensembl
TCGA novel	211	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	219	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414035274 rs1603241714	228	L>F		No	ClinGen Ensembl
CA414035285 rs1556038529	229	T>I		No	ClinGen gnomAD
rs1556038540 CA414035301	231	M>I		No	ClinGen gnomAD
rs1556038544 CA414035311	233	V>I		No	ClinGen gnomAD
CA414035318 rs1556038545	234	T>A		No	ClinGen gnomAD
rs781828907 CA10474104	234	T>I		No	ClinGen ExAC gnomAD
CA10474105 rs782461535	237	Y>H		No	ClinGen ExAC gnomAD
CA10474106 rs782809877	239	H>L		No	ClinGen ExAC gnomAD
TCGA novel	239	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414035407 rs1250495596	242	A>T		No	ClinGen TOPMed gnomAD
TCGA novel	243	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414035431 rs1556038563	243	N>S		No	ClinGen gnomAD
rs868972628 CA414035448	244	S>F		No	ClinGen Ensembl
CA10474107 rs781882226	245	I>V		No	ClinGen ExAC gnomAD
CA414035473 rs1556038573	246	S>C		No	ClinGen TOPMed
CA333873616 rs997449630	246	S>P		No	ClinGen gnomAD
CA10474108 rs782505708	247	D>E		No	ClinGen ExAC TOPMed gnomAD
CA414035531 rs1556038584	250	R>C		No	ClinGen gnomAD
rs1556038592 CA414035541	250	R>L		No	ClinGen gnomAD
rs376915704 CA414035559	251	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	251	L>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1301129701 CA414035597	254	A>T		No	ClinGen TOPMed
rs782224564 CA10474110	254	A>V		No	ClinGen ExAC gnomAD
rs1556038598 CA414035629	256	N>T		No	ClinGen gnomAD
CA414035676 rs1232255100	259	T>A		No	ClinGen TOPMed gnomAD
TCGA novel	268	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782178210 CA10474114	268	L>S		No	ClinGen ExAC TOPMed
CA10474115 rs782423340	272	E>K		No	ClinGen ExAC
CA10474117 rs782264611	275	A>V		No	ClinGen ExAC gnomAD
CA414036016 rs1394808823	282	R>G		No	ClinGen TOPMed
rs955786842 CA333873617	283	A>T		No	ClinGen Ensembl
CA333873618 rs200063096	283	A>V		No	ClinGen 1000Genomes TOPMed gnomAD
rs1556038640 CA414036073	285	V>A		No	ClinGen gnomAD
CA10474120 rs369278711	286	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1556038652 CA414036105	288	S>P		No	ClinGen gnomAD
rs1453342357 CA414036114	289	L>V		No	ClinGen TOPMed
rs1200569279 CA414036219	296	K>E		No	ClinGen TOPMed
rs1249343569 CA414036261	298	N>S		No	ClinGen TOPMed
CA10474123 rs781925495	300	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10474124 rs782144980	301	V>F		No	ClinGen ExAC gnomAD
CA10474125 rs138110734	303	L>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	307	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781847660 CA10474126	307	V>I		No	ClinGen ExAC
CA10474127 rs782091422	309	F>S		No	ClinGen ExAC
rs868971969 CA414036442	311	N>D		No	ClinGen Ensembl
rs1347256535 CA414036460	312	I>L		No	ClinGen TOPMed gnomAD
rs1304190214 CA414036466	312	I>T		No	ClinGen TOPMed gnomAD
TCGA novel	313	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782721194 CA10474128	315	N>H		No	ClinGen ExAC gnomAD
CA10474129 rs781802741	317	K>R		No	ClinGen ExAC gnomAD
CA414036575 rs1556038716	318	W>C		No	ClinGen gnomAD
rs143586223 CA333873619	318	W>R		No	ClinGen ESP TOPMed
rs782428966 CA10474130	320	E>*		No	ClinGen ExAC gnomAD
TCGA novel	323	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10474131 rs199850913	324	T>I		No	ClinGen ExAC gnomAD
TCGA novel	325	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA333873620 rs973119559	329	G>S		No	ClinGen Ensembl
CA414036756 rs1556038734	330	E>Q		No	ClinGen gnomAD
rs1556038737 CA414036774	331	G>S		No	ClinGen gnomAD
rs1556038740 CA414036784	331	G>V		No	ClinGen gnomAD
CA10474133 rs782522314	333	L>F		No	ClinGen ExAC TOPMed gnomAD
CA10474136 rs782239191	335	F>L		No	ClinGen ExAC gnomAD
rs115179885 CA10474134	335	F>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10474137 rs782582627	337	L>F		No	ClinGen ExAC TOPMed gnomAD
CA414036959 rs1434581838	342	V>G		No	ClinGen TOPMed
CA10474139 rs782629163	354	H>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA333873621 rs937177302	354	H>Y		No	ClinGen Ensembl
TCGA novel	357	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781999648 CA10474141	358	V>A		No	ClinGen ExAC TOPMed gnomAD
CA414037318 rs1182075910	366	M>K		No	ClinGen TOPMed
CA414037315 rs1569370721	366	M>L		No	ClinGen Ensembl
CA414037341 rs1473452588	367	A>V		No	ClinGen TOPMed
CA414037367 rs1255062436	369	L>P		No	ClinGen TOPMed gnomAD
CA414037369 rs1255062436	369	L>R		No	ClinGen TOPMed gnomAD
CA10474146 rs782704817	373	M>I		No	ClinGen ExAC TOPMed gnomAD
CA333873622 rs200712003	373	M>K		No	ClinGen Ensembl
CA414037440 rs1041663254	374	F>I		No	ClinGen TOPMed
CA333873623 rs1041663254	374	F>L		No	ClinGen TOPMed
rs1229173568 CA414037507	378	Q>R		No	ClinGen TOPMed

No associated diseases with Q9UH62

1 regional properties for Q9UH62

Type	Name	Position	InterPro Accession
domain	Signal transduction response regulator, receiver domain	28 - 146	IPR001789

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion outer membrane ; Single-pass membrane protein Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
axon cytoplasm	Any cytoplasm that is part of a axon.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of mitochondrial outer membrane	The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name	Definition
axonal transport of mitochondrion	The directed movement of mitochondria along microtubules in nerve cell axons.
mitochondrion organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein localization	Any process in which a protein is transported to, or maintained in, a specific location.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6P1M9	ARMCX5	Armadillo repeat-containing X-linked protein 5	Homo sapiens (Human)	PR
Q3UZB0	Armcx5	Armadillo repeat-containing X-linked protein 5	Mus musculus (Mouse)	PR
Q5U4C1	Gprasp1	G-protein coupled receptor-associated sorting protein 1	Mus musculus (Mouse)	PR
Q8BUY8	Gprasp2	G-protein coupled receptor-associated sorting protein 2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MGYARKVGWV	TAGLVIGAGA	CYCIYRLTRG	RKQNKEKMAE	GGSGDVDDAG	DCSGARYNDW
70	80	90	100	110	120
SDDDDDSNES	KSIVWYPPWA	RIGTEAGTRA	RARARARATR	ARRAVQKRAS	PNSDDTVLSP
130	140	150	160	170	180
QELQKVLCLV	EMSEKPYILE	AALIALGNNA	AYAFNRDIIR	DLGGLPIVAK	ILNTRDPIVK
190	200	210	220	230	240
EKALIVLNNL	SVNAENQRRL	KVYMNQVCDD	TITSRLNSSV	QLAGLRLLTN	MTVTNEYQHM
250	260	270	280	290	300
LANSISDFFR	LFSAGNEETK	LQVLKLLLNL	AENPAMTREL	LRAQVPSSLG	SLFNKKENKE
310	320	330	340	350	360
VILKLLVIFE	NINDNFKWEE	NEPTQNQFGE	GSLFFFLKEF	QVCADKVLGI	ESHHDFLVKV
370
KVGKFMAKLA	EHMFPKSQE