Q8BUY8
Gene name |
Gprasp2 |
Protein name |
G-protein coupled receptor-associated sorting protein 2 |
Names |
GASP-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:245607 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BUY8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BUY8-F1 | Predicted | AlphaFoldDB |
37 variants for Q8BUY8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3411639970 | 20 | E>G | No | EVA | |
| rs3411976130 | 20 | E>S | No | EVA | |
| rs29265141 | 70 | S>P | No | EVA | |
| rs29265140 | 83 | P>L | No | EVA | |
| rs3389585709 | 102 | V>I | No | EVA | |
| rs3412499932 | 130 | E>G | No | EVA | |
| rs3412302043 | 130 | E>K | No | EVA | |
| rs3389589004 | 134 | E>Q | No | EVA | |
| rs3410710660 | 149 | T>I | No | EVA | |
| rs265768402 | 155 | V>A | No | EVA | |
| rs244663720 | 203 | S>P | No | EVA | |
| rs3412086259 | 373 | E>V | No | EVA | |
| rs3413091543 | 390 | V>L | No | EVA | |
| rs3412112677 | 399 | D>H | No | EVA | |
| rs221613815 | 400 | A>T | No | EVA | |
| rs231268276 | 403 | G>V | No | EVA | |
| rs3409343841 | 404 | A>P | No | EVA | |
| rs3389569897 | 414 | F>L | No | EVA | |
| rs3389572371 | 452 | F>I | No | EVA | |
| rs3389554860 | 488 | E>G | No | EVA | |
| rs265884096 | 534 | A>V | No | EVA | |
| rs29264923 | 575 | T>I | No | EVA | |
| rs29264923 | 575 | T>N | No | EVA | |
| rs3389589188 | 596 | D>V | No | EVA | |
| rs3412086274 | 628 | G>I | No | EVA | |
| rs3389579383 | 649 | L>W | No | EVA | |
| rs3411202954 | 659 | Y>* | No | EVA | |
| rs3411976177 | 669 | I>F | No | EVA | |
| rs224785934 | 680 | S>T | No | EVA | |
| rs3389585711 | 691 | R>W | No | EVA | |
| rs3389579362 | 694 | R>K | No | EVA | |
| rs3410540604 | 725 | K>M | No | EVA | |
| rs3411203011 | 728 | V>G | No | EVA | |
| rs3389584326 | 729 | L>P | No | EVA | |
| rs3410592434 | 782 | K>PG* | No | EVA | |
| rs3389572328 | 784 | G>E | No | EVA | |
| rs3389554892 | 801 | A>V | No | EVA |
No associated diseases with Q8BUY8
1 regional properties for Q8BUY8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Armadillo repeat-containing domain | 584 - 801 | IPR006911 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| amyloid-beta binding | Binding to an amyloid-beta peptide/protein. |
| G protein-coupled receptor binding | Binding to a G protein-coupled receptor. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| hematopoietic stem cell homeostasis | Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6P1M9 | ARMCX5 | Armadillo repeat-containing X-linked protein 5 | Homo sapiens (Human) | PR |
| Q9UH62 | ARMCX3 | Armadillo repeat-containing X-linked protein 3 | Homo sapiens (Human) | PR |
| Q3UZB0 | Armcx5 | Armadillo repeat-containing X-linked protein 5 | Mus musculus (Mouse) | PR |
| Q5U4C1 | Gprasp1 | G-protein coupled receptor-associated sorting protein 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTGAEVETGS | QAKPDKKPQE | EVAGGAERES | EAPLVVRPKV | RPQAPATSGA | RPKTETKSSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RARPKTETQS | VSGTRHRMSG | ARPRSEAQLM | SGARPKTDAR | AVGGARPKTE | AKPIPGARPK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GDAQAWAHSE | FGAEAMPRAE | RAHLSNSVTW | PPVNVGSATV | TKSKSLSMNT | ELASMGSEIF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGTQGQPGIE | PWFGPREEAN | MGSWCYPRPR | AREETSNESA | DENSTMSSFW | TREETSIRSW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PREEVNTRSR | HRAKHQTNAR | SKPRSKQDPY | IDSLSGSEDE | ASNPFCFWAG | ENTNDMFRAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GRDEANARPK | IRTKREDYFE | DEDEIYKESW | LLPGEEGNRF | RRRDKEEPNK | TLKNENEKDV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KNDETVEQES | RLEEEVIIGS | WFWAEQETNV | EAGASAICDA | EPGAEEGAIG | GSLFWTEEKP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLGAVARDEV | RPESEEEALF | GSWFWDRDEA | CFDPNPTPVY | TAKSRYRDPE | EDLNLASRPK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TWDEVTIEFK | PPCHGLGFPS | PRPFIIPEGA | SGNSEEKAKN | AELGAEGEEQ | DSVAQRDLPE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PEFPFQYDPS | YRSVQEIREH | LKARESAQPE | NWSCTCIQCE | LRISSAEFEE | LLLLMDRIRD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PFIHEIAKIA | MGMRTASQFT | RDFIRDSGVV | SLIEALMNYP | SSRVRTNFLE | NMVHMAPPYP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NLNMIETFIC | QVCEETLSHS | VNSPEQLTGM | RMLRHLTITT | DYHVLIANYV | SGFLALLTTG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DARTKFHVLK | MLLNLSDNPM | VAKKLFSAKA | LSIFVGLFNI | EETNDNIQIV | IKMFQNISNI |
| 790 | 800 | 810 | 820 | ||
| VKSGAMSLLD | DDFSLEPLVS | AFHEFEELAK | QLQIQIDNQN | DPEEGQ |