Q5U4C1
PR
Gene name |
Gprasp1 (Kiaa0443) |
Protein name |
G-protein coupled receptor-associated sorting protein 1 |
Names |
GASP-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67298 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5U4C1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5U4C1-F1 | Predicted | AlphaFoldDB |
121 variants for Q5U4C1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389589118 | 10 | A>G | No | EVA | |
| rs3412301964 | 92 | V>L | No | EVA | |
| rs230807429 | 95 | P>S | No | EVA | |
| rs3389543212 | 110 | C>Y | No | EVA | |
| rs3389524808 | 141 | N>D | No | EVA | |
| rs3389567837 | 142 | M>I | No | EVA | |
| rs254607179 | 161 | Y>F | No | EVA | |
| rs254607179 | 161 | Y>S | No | EVA | |
| rs3411976085 | 162 | G>E | No | EVA | |
| rs227213973 | 175 | A>P | No | EVA | |
| rs3389569937 | 177 | P>S | No | EVA | |
| rs3412499841 | 178 | V>L | No | EVA | |
| rs3412110742 | 182 | E>Q | No | EVA | |
| rs3389554843 | 191 | W>R | No | EVA | |
| rs3389483464 | 195 | P>L | No | EVA | |
| rs222906765 | 209 | T>P | No | EVA | |
| rs3409343882 | 210 | R>K | No | EVA | |
| rs864265160 | 214 | R>W | No | EVA | |
| rs3389576085 | 221 | N>I | No | EVA | |
| rs3389584311 | 221 | N>K | No | EVA | |
| rs3389567817 | 231 | A>G | No | EVA | |
| rs3411976096 | 248 | S>R | No | EVA | |
| rs29265974 | 255 | S>P | No | EVA | |
| rs3412084760 | 328 | R>S | No | EVA | |
| rs238807785 | 344 | G>A | No | EVA | |
| rs254138410 | 361 | A>T | No | EVA | |
| rs29265653 | 363 | V>A | No | EVA | |
| rs3389576152 | 379 | P>S | No | EVA | |
| rs3389531719 | 431 | I>M | No | EVA | |
| rs29265652 | 482 | S>C | No | EVA | |
| rs3389531755 | 520 | F>L | No | EVA | |
| rs263916430 | 526 | N>H | No | EVA | |
| rs3389576147 | 531 | V>A | No | EVA | |
| rs3389570033 | 536 | E>* | No | EVA | |
| rs3411975462 | 538 | M>IQK* | No | EVA | |
| rs251939803 | 541 | A>V | No | EVA | |
| rs29265650 | 544 | K>R | No | EVA | |
| rs225729903 | 549 | S>P | No | EVA | |
| rs245719019 | 558 | T>P | No | EVA | |
| rs219441492 | 602 | A>T | No | EVA | |
| rs3389575464 | 630 | L>H | No | EVA | |
| rs3389576094 | 637 | I>L | No | EVA | |
| rs3389567838 | 649 | D>V | No | EVA | |
| rs240222414 | 656 | I>V | No | EVA | |
| rs29265648 | 662 | A>G | No | EVA | |
| rs29265648 | 662 | A>V | No | EVA | |
| rs3389569966 | 691 | T>S | No | EVA | |
| rs3412084828 | 710 | R>P | No | EVA | |
| rs238718573 | 713 | T>S | No | EVA | |
| rs3411638155 | 716 | G>W | No | EVA | |
| rs3389483475 | 720 | W>* | No | EVA | |
| rs3410591201 | 725 | G>E | No | EVA | |
| rs3389576106 | 734 | K>R | No | EVA | |
| rs218881721 | 756 | S>T | No | EVA | |
| rs241071993 | 758 | V>I | No | EVA | |
| rs266223896 | 762 | K>N | No | EVA | |
| rs29265646 | 766 | F>S | No | EVA | |
| rs29265645 | 789 | E>Q | No | EVA | |
| rs263387625 | 790 | P>S | No | EVA | |
| rs3389574150 | 791 | A>D | No | EVA | |
| rs225438034 | 794 | I>T | No | EVA | |
| rs3411875625 | 797 | E>K | No | EVA | |
| rs245688453 | 804 | D>E | No | EVA | |
| rs3412499885 | 813 | W>* | No | EVA | |
| rs3389575427 | 819 | S>I | No | EVA | |
| rs3389554848 | 824 | R>I | No | EVA | |
| rs29265644 | 826 | G>V | No | EVA | |
| rs29265303 | 827 | T>P | No | EVA | |
| rs3389574140 | 831 | A>D | No | EVA | |
| rs3389574140 | 831 | A>V | No | EVA | |
| rs3389579391 | 833 | G>E | No | EVA | |
| rs253785312 | 840 | T>S | No | EVA | |
| rs3389567761 | 846 | T>A | No | EVA | |
| rs3411976109 | 858 | V>L | No | EVA | |
| rs3409343863 | 861 | G>A | No | EVA | |
| rs3389589171 | 875 | W>* | No | EVA | |
| rs3389575420 | 881 | S>T | No | EVA | |
| rs29265302 | 882 | I>M | No | EVA | |
| rs238043383 | 890 | S>P | No | EVA | |
| rs258481339 | 891 | K>Q | No | EVA | |
| rs29265301 | 893 | K>N | No | EVA | |
| rs3389575431 | 894 | D>A | No | EVA | |
| rs232216825 | 895 | D>E | No | EVA | |
| rs248264400 | 897 | N>D | No | EVA | |
| rs3389572348 | 905 | W>C | No | EVA | |
| rs3389567766 | 913 | E>D | No | EVA | |
| rs3389524823 | 923 | S>N | No | EVA | |
| rs3389585629 | 940 | D>N | No | EVA | |
| rs3389569933 | 955 | S>N | No | EVA | |
| rs242604726 | 956 | T>A | No | EVA | |
| rs3389524794 | 958 | A>V | No | EVA | |
| rs3389575418 | 962 | V>L | No | EVA | |
| rs261095296 | 985 | V>I | No | EVA | |
| rs3389531736 | 993 | E>D | No | EVA | |
| rs3389543204 | 996 | P>T | No | EVA | |
| rs3389579378 | 1002 | P>L | No | EVA | |
| rs3389575473 | 1007 | E>K | No | EVA | |
| rs29265300 | 1009 | T>N | No | EVA | |
| rs259709092 | 1014 | A>P | No | EVA | |
| rs3389574157 | 1015 | G>V | No | EVA | |
| rs3389589143 | 1027 | P>R | No | EVA | |
| rs224950495 | 1060 | Q>R | No | EVA | |
| rs29265297 | 1093 | N>T | No | EVA | |
| rs3389575432 | 1114 | D>E | No | EVA | |
| rs3389575429 | 1126 | K>N | No | EVA | |
| rs3389524812 | 1129 | M>L | No | EVA | |
| rs3389531782 | 1137 | F>C | No | EVA | |
| rs3389554830 | 1139 | R>G | No | EVA | |
| rs3389574145 | 1143 | R>G | No | EVA | |
| rs3389575468 | 1151 | I>T | No | EVA | |
| rs3389567798 | 1165 | R>W | No | EVA | |
| rs3389584374 | 1191 | C>Y | No | EVA | |
| rs29265295 | 1197 | Y>S | No | EVA | |
| rs29265294 | 1201 | S>T | No | EVA | |
| rs3389579358 | 1203 | D>E | No | EVA | |
| rs3389589125 | 1217 | T>I | No | EVA | |
| rs3389584372 | 1220 | Y>C | No | EVA | |
| rs29264982 | 1240 | T>I | No | EVA | |
| rs3389569939 | 1242 | T>I | No | EVA | |
| rs3389483403 | 1264 | L>I | No | EVA | |
| rs864258523 | 1313 | E>D | No | EVA |
No associated diseases with Q5U4C1
1 regional properties for Q5U4C1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Armadillo repeat-containing domain | 1103 - 1304 | IPR006911 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| endosome to lysosome transport | The directed movement of substances from endosomes to lysosomes. |
| G protein-coupled receptor catabolic process | The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6P1M9 | ARMCX5 | Armadillo repeat-containing X-linked protein 5 | Homo sapiens (Human) | PR |
| Q9UH62 | ARMCX3 | Armadillo repeat-containing X-linked protein 3 | Homo sapiens (Human) | PR |
| Q3UZB0 | Armcx5 | Armadillo repeat-containing X-linked protein 5 | Mus musculus (Mouse) | PR |
| Q8BUY8 | Gprasp2 | G-protein coupled receptor-associated sorting protein 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTRAEVEPGA | QAKAENKPGD | ENANAAEVEP | EAPLVVRPKV | RTQIMTGARP | KVKPKGTPGA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RPKGETSTPG | GAYAKCKPKA | IPIARSKHDA | QVWAPNKFRG | ESMSKMGKQC | QISAADPPLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SNDSGMVAQA | KCLPVDRELA | NMDTESIPKK | ANSPAGFQPS | YGSEEGTNMG | SWYRARPVPK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GEAYENSDFK | WADKPSGSPS | FWNRDEASTR | FRPRKSMKAN | NRFRHMAKQE | ANTMPRHKNK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QEFYNISSSD | SEDESGKTPW | FWPKDKTKVW | SKPKEEPNSR | SWFRSKKEVR | VESTSGSECE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPTKSLFWSG | EEAKSRSKPR | ARKGVNMRAR | QQAKREACSD | AMSGAIDTNK | KESWFLPEEK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ANVFSKSKTK | KEPRTRAVPK | EEVKTKARAS | TKQEARPEEE | VLVGAWFWDT | QESTMADRIS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IKTTFVEEEP | IVGDWFWSEE | EASVDSETCH | TSRPRAKEEQ | VSSFCLGSGK | KSSMESGPKA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TSKSMPVAKE | DEVVIGSWFW | ADDEEINLQA | DDESIFGSWF | WGTGENSLRS | VGVNCEKMPK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AGEKEVTDSW | FWAGDVNTEA | EVEEQARSAS | TKATIFVPWF | WSEKQPNMDL | GSEPCSDIMA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GAEEEPIIGP | WFWAKVDNSV | EAEVNSKSSL | EDEEEPIRSP | WFGAREQTDM | KYAAGIRYKP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MAEAEDANKK | SCVWAKEPCL | YPTNRECLKS | TLGEKEDTVD | PWLWSNNYPR | TKTITGSWLW |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AAEEGNIDDE | TGEKIKLPTL | EDNAFNSWFW | KENEESIVEA | PKREEFRPEA | EEEDIIGSWF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| WAGDEDRFEP | AAKINEENKI | ASEDEDTVGS | WFWGNEEASL | EAVRRGTFES | APGIKEEKVT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GSWFWTDKAK | VGAGSQTVET | GSETEEEAIF | ESLIWAAKKD | SIQAGVKRVS | KPKDDGNIAV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GSWLWSSDKA | TKEAKTLIVS | EASPENGKES | VVKFGSRAKD | EVINKTGSGD | NCKHSTEAET |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IVGAWFWEGD | EASFESNPVP | VCKAVCEPES | SAEHEPDPSR | RPQSWDEVTV | QFKAGPWGKA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GFPPMNPFRF | PKEAASLFAE | MFGGKPKLVE | VGPEREPEPQ | FPFQYDPSYR | SVREIREHLK |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| ARESAQPENW | SCNCIQCELR | IGSEEFEELL | LLMDRNRDPF | IHEISKIAMG | MRGASQFTRD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| FIRNSGVVSL | IEALLNYPSS | RVRTRFLENM | VRMAPPYPDL | NMIETYVCQI | CEDTFDYDLD |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SPDQLSGLTM | ITHLTATSDY | HKVVVNYLAG | FFYLLNSGNT | KTRFHVLKLL | LNLSENLVMT |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| KRLLVTDSVS | EFMDLINREE | SDENIQIVLA | IFETISKHIQ | KEALFSDDDD | DDEEEDAVNL |
| 1330 | 1340 | ||||
| EPFISAFREA | EKIAKELKRK | PGNQKAP |