Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9U3H8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9U3H8-F1 | Predicted | AlphaFoldDB |
No variants for Q9U3H8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9U3H8 | |||||
No associated diseases with Q9U3H8
4 regional properties for Q9U3H8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 225 - 302 | IPR000504-1 |
| domain | RNA recognition motif domain | 326 - 406 | IPR000504-2 |
| domain | RNA recognition motif domain | 446 - 521 | IPR000504-3 |
| domain | ESRP1, RNA recognition motif 1 | 216 - 308 | IPR034427 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| maintenance of protein localization in endoplasmic reticulum | Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum. |
| positive regulation of cilium assembly | Any process that activates or increases the frequency, rate or extent of the formation of a cilium. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40085 | EMP65 | Endoplasmic reticulum membrane protein 65 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZLG8 | TAPT1 | Transmembrane anterior posterior transformation protein 1 homolog | Gallus gallus (Chicken) | PR |
| Q4VBD2 | Tapt1 | Transmembrane anterior posterior transformation protein 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNNVPSTSRE | NSRNPSESSS | SIQDLLINVE | ANDLSSVVNE | DVSITMSAPP | SPATPRKIDF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAEIETPKST | GIRRRLTLKD | SIGSDLENDP | ESTPAIRKPS | RISYDERLTV | ICDSQTSSPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QTPSPSQERD | SAPFADVFQP | KGFFSFFWEE | LTRGYSLHND | HARFSEKRRK | VYAFLRIPLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEQFLTYGLL | QCIDAFFYLF | TFLPLRFLMS | IFGALLRIKR | WTSAETCDFL | KVVIIVAASM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LIREIDSSFL | YHQVRSQGVI | KLYIFYNMLE | VADRLFSSLG | QDIFDALLWT | ANSEKRFSVG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YFIRTCGHLI | VAILYATLHS | FLVILQATTL | NVAFNSHNQT | VLAIMMSNNF | VELKGSVFKK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FAKANLFQMA | CSDVRERFHI | FALLFVVMIR | NMTAVNWNID | SFTEMIPDII | MVVGCEYFVD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WLKHAFITKF | NEINAEVYKD | FTITIAFDVI | RSRDQSAFSD | YSDQVSRRMG | FIPIPLSIMI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRVLSQTFTL | DNWGSCIIFG | IGWLLVFAVK | ICNGVVMLGQ | ACHHVKRFRD | IQARAEFELF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RKRMVEKKSK | SAPNSPRMSL | IDFTDVLHQP | AAGKGFTVSD | MLSQWEELQP | SLLSSEIRRS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TDRETAVSHL | TARSDERTPR | RAVSMAHIPR | RDRSEPPPAP | SMDQDPQLDT | EDPVVTENNT |
| 670 | 680 | 690 | 700 | 710 | |
| NSNSEQASPV | KKKTTAAPVT | SSASTNTNAT | SSDELADVTA | YKMPEQGVQR | IE |