Q4VBD2
PR
Gene name |
Tapt1 |
Protein name |
Transmembrane anterior posterior transformation protein 1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:231225 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4VBD2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4VBD2-F1 | Predicted | AlphaFoldDB |
16 variants for Q4VBD2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388743796 | 127 | L>I | No | EVA | |
| rs3388756885 | 150 | R>H | No | EVA | |
| rs3388753315 | 212 | Q>E | No | EVA | |
| rs3388760731 | 232 | H>Y | No | EVA | |
| rs3388760725 | 239 | F>L | No | EVA | |
| rs3388756900 | 332 | L>H | No | EVA | |
| rs3388748327 | 405 | P>Q | No | EVA | |
| rs226625217 | 486 | P>S | No | EVA | |
| rs3413085433 | 489 | G>V | No | EVA | |
| rs36323740 | 492 | T>R | No | EVA | |
| rs3388760256 | 495 | N>K | No | EVA | |
| rs3388743811 | 495 | N>Y | No | EVA | |
| rs3388763033 | 504 | P>L | No | EVA | |
| rs3388761136 | 513 | P>S | No | EVA | |
| rs239594919 | 519 | N>T | No | EVA | |
| rs3388760596 | 561 | N>H | No | EVA |
No associated diseases with Q4VBD2
6 regional properties for Q4VBD2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GAF domain | 159 - 318 | IPR003018 |
| domain | Histidine kinase/HSP90-like ATPase | 456 - 589 | IPR003594 |
| domain | Signal transduction histidine kinase, dimerisation/phosphoacceptor domain | 344 - 409 | IPR003661 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 512 - 526 | IPR004358-1 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 546 - 564 | IPR004358-2 |
| domain | Histidine kinase domain | 351 - 589 | IPR005467 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| anatomical structure development | The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. |
| cartilage development | The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. |
| cell projection organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. |
| embryonic skeletal system development | The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. |
| maintenance of protein localization in endoplasmic reticulum | Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum. |
| neural crest cell development | The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. |
| ossification | The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. |
| positive regulation of bone development | Any process that activates or increases the frequency, rate or extent of bone development. |
| positive regulation of cartilage development | Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. |
| positive regulation of cilium assembly | Any process that activates or increases the frequency, rate or extent of the formation of a cilium. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40085 | EMP65 | Endoplasmic reticulum membrane protein 65 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZLG8 | TAPT1 | Transmembrane anterior posterior transformation protein 1 homolog | Gallus gallus (Chicken) | PR |
| Q9U3H8 | F26F2.7 | Protein TAPT1 homolog | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGVCDAAAP | GEGGGGGADG | PERTGRGEAE | QPGGGGHGPA | PQHTETLGFY | ESDRRREKRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRAELSLLRF | LSAELTRGYF | LEHNEAKYTE | RRERVYTCMR | IPRELEKLMF | FGIFLCLDAF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LYVFTLLPLR | VFLALFRLLT | LPCYGLRDRR | LLQPAQVCDI | LKGVILVICY | FMMHYVDYSM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MYHLIRGQSV | IKLYIIYNML | EVADRLFSSF | GQDILDALYW | TATEPKERKR | AHIGVIPHFF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MAVLYVFLHA | ILIMVQATTL | NVAFNSHNKS | LLTIMMSNNF | VEIKGSVFKK | FEKNNLFQMS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSDIKERFTN | YVLLLIVCLR | NMEQFSWNPD | HLWVLFPDVC | MVIASEIAVD | IVKHAFITKF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NDITADVYSE | YRASLAFDLV | SSRQKNAYTD | YSDSVARRMG | FIPLPLAVLL | IRVVTSSIKV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QGILSYACVI | LFYFGLISLK | ILNSIVLLGK | SCQYVKEAKM | EEKLFNPPPA | STPGKPSSKS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QSKGKPSQGL | STEENLSASV | TSQPGHQKEN | VIPLLVTSNS | DQFLTTPDGD | EKDITQENSE |
| 550 | 560 | ||||
| LKHRSSKKDL | LEIDRFTICG | NRID |