P40085
Gene name |
EMP65 |
Protein name |
Endoplasmic reticulum membrane protein 65 |
Names |
65 kDa endoplasmic reticulum membrane protein |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YER140W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P40085
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P40085-F1 | Predicted | AlphaFoldDB |
4 variants for P40085
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s05-451705 | 49 | I>T | No | SGRP | |
| s05-452946 | 463 | A>T | No | SGRP | |
| s05-452949 | 464 | F>L | No | SGRP | |
| s05-453112 | 518 | L>S | No | SGRP |
No associated diseases with P40085
No regional properties for P40085
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P40085 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| maintenance of protein localization in endoplasmic reticulum | Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum. |
| protein folding in endoplasmic reticulum | A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZLG8 | TAPT1 | Transmembrane anterior posterior transformation protein 1 homolog | Gallus gallus (Chicken) | PR |
| Q4VBD2 | Tapt1 | Transmembrane anterior posterior transformation protein 1 | Mus musculus (Mouse) | PR |
| Q9U3H8 | F26F2.7 | Protein TAPT1 homolog | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQHKDTAVAK | DTAKKRLLRR | NSAPSAIHII | SRLDKKWSFL | WNTIDRHNIV | EEQDESSAAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SEEEHEDDYE | LEQLLNMIRI | PMFLEKFMLF | ALLTSLDCFL | YYFTVLPIRL | IKGYVKQFKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YRQHYRLQQR | SGHKNKIPFR | YRITSREYKE | RCMIFIIVIS | SILLSKLDTS | KLYHRIKRQS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TMKLYMLFSV | LEMADKMLAS | LGQSLLTVML | SRKNSERILL | HKCLLVSMSL | TYVTIHGYVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VYQAISLNIA | VNSYSNALLT | LLLSMQFAEI | KSSVLKKFDK | EGFFQITIAD | VVERFKLTLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSITGLRNLQ | SWSSSLSNTS | INFWSPRSTL | SIVINILCGP | MVSVVGSEVL | VDWAKHAYIT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KFNRIRPQIY | DKFYYIIYKD | YSTRTHKLED | RLGLPLPAFV | VLFIVMVRPT | LFKSSEPSYL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PSLFRILFMG | ASVFLLALLA | KFTLDLILIK | WSKRIEQRFR | DQAFNTVVTE | EEYVPGLLSG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GMGKVDVSTR | IALHSDYNKE | NRIETESVSP | MRKRKTTLTA | ECTPPSLNDI | RRQKDSKNPR |
| 550 | |||||
| SLENVARYKM | VSKRIW |