Q9U3C8
Gene name |
dcn-1 (H38K22.2) |
Protein name |
Defective in cullin neddylation protein 1 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_H38K22.2 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9U3C8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9U3C8-F1 | Predicted | AlphaFoldDB |
No variants for Q9U3C8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9U3C8 | |||||
No associated diseases with Q9U3C8
1 regional properties for Q9U3C8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Potentiating neddylation domain | 60 - 272 | IPR005176 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ubiquitin ligase complex | A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cullin family protein binding | Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
| ubiquitin conjugating enzyme binding | Binding to a ubiquitin conjugating enzyme, any of the E2 proteins. |
| ubiquitin-like protein binding | Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| astral microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles. |
| establishment of mitotic spindle localization | The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. |
| positive regulation of ubiquitin-protein transferase activity | Any process that activates, maintains or increases the rate of ubiquitin transferase activity. |
| protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| protein neddylation | Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9V1 | DCUN1D3 | DCN1-like protein 3 | Bos taurus (Bovine) | PR |
| Q8IWE4 | DCUN1D3 | DCN1-like protein 3 | Homo sapiens (Human) | PR |
| Q8K0V2 | Dcun1d3 | DCN1-like protein 3 | Mus musculus (Mouse) | PR |
| Q4V8B2 | Dcun1d3 | DCN1-like protein 3 | Rattus norvegicus (Rat) | PR |
| A4IHK8 | dcun1d3 | DCN1-like protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRLKSDQKT | KLRQFVQWTQ | VTEAVSLNFL | AKANWNIEYA | MTLYFDNPNL | FAGSTPQPSV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRSNIERLFN | QYVDPKDKVG | EKRMGPHGIN | RLLTDLGYEA | TDRRVLVLAW | KFTAQTQCEF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLDEWVKGMT | ALQADTVQNL | RQRIDSINSG | LESDKAKFHE | LYLFAFNYAK | SAACRNLDLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TAICCWDVLF | GQRSTIMTQW | IDFLWAQENA | AASRLAQNVG | ASNAKQFKSV | WISRDTWNLF |
| 250 | 260 | 270 | 280 | 290 | |
| WDFILLSKPD | LSDYDDEGAW | PVLIDQFVDY | CRENLNYPKP | GNASNDQQME | TPSYY |