Q4V8B2

PR
Gene name
Dcun1d3
Protein name
DCN1-like protein 3
Names
DCNL3, DCUN1 domain-containing protein 3, Defective in cullin neddylation protein 1-like protein 3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:309035
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-117 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4V8B2

Entry ID Method Resolution Chain Position Source
AF-Q4V8B2-F1 Predicted AlphaFoldDB

No variants for Q4V8B2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4V8B2

No associated diseases with Q4V8B2

1 regional properties for Q4V8B2

Type Name Position InterPro Accession
domain Potentiating neddylation domain 86 - 278 IPR005176

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
  • Cytoplasm
  • Nucleus
  • Cytoplasm, perinuclear region
  • After UVC treatment, the protein enters to the nucleus gradually
  • Cell membrane localization is essential for CUL3 neddylation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

3 GO annotations of molecular function

Name Definition
cullin family protein binding Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3).
ubiquitin conjugating enzyme binding Binding to a ubiquitin conjugating enzyme, any of the E2 proteins.
ubiquitin-like protein binding Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.

11 GO annotations of biological process

Name Definition
negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of G1/S transition of mitotic cell cycle Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
negative regulation of protein neddylation Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of protein neddylation Any process that activates or increases the frequency, rate or extent of protein neddylation.
positive regulation of ubiquitin-protein transferase activity Any process that activates, maintains or increases the rate of ubiquitin transferase activity.
protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
regulation of cell cycle process Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
regulation of protein neddylation Any process that modulates the frequency, rate or extent of protein neddylation.
response to gamma radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
response to UV-C Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9V1 DCUN1D3 DCN1-like protein 3 Bos taurus (Bovine) PR
Q8IWE4 DCUN1D3 DCN1-like protein 3 Homo sapiens (Human) PR
Q8K0V2 Dcun1d3 DCN1-like protein 3 Mus musculus (Mouse) PR
Q9U3C8 dcn-1 Defective in cullin neddylation protein 1 Caenorhabditis elegans PR
A4IHK8 dcun1d3 DCN1-like protein 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MGQCVTKCKN PSSTLGSKNG DRDPSSKSHS RRGASHREEQ VPPCGKPAGD ILVNGTKKAE
70 80 90 100 110 120
AATEACQLPT SSGDAGRESK TNAEESSLQR LEELFRRYKD EREDAILEEG MERFCNDLCV
130 140 150 160 170 180
DPTEFRVLLL AWKFQAATMC KFTRKEFFDG CKAISADSID GICARFPSLL TEAKQEDKFK
190 200 210 220 230 240
DLYRFTFQFG LDSEEGQRSL HREIAIALWK LVFTQNNPPV LDQWLNFLTE NPSGIKGISR
250 260 270 280 290 300
DTWNMFLNFT QVIGPDLSNY SEDEAWPSLF DTFVEWEMER RKREVEGRGA LSSGPEGLCP
EEQT