Q8K0V2
PR
Gene name |
Dcun1d3 |
Protein name |
DCN1-like protein 3 |
Names |
DCNL3, DCUN1 domain-containing protein 3, Defective in cullin neddylation protein 1-like protein 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:233805 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K0V2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K0V2-F1 | Predicted | AlphaFoldDB |
10 variants for Q8K0V2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388921447 | 38 | E>V | No | EVA | |
| rs3388941336 | 74 | D>G | No | EVA | |
| rs3388915066 | 89 | Q>K | No | EVA | |
| rs32579926 | 102 | R>Q | No | EVA | |
| rs3398242455 | 131 | A>* | No | EVA | |
| rs3388915043 | 209 | W>C | No | EVA | |
| rs3388941685 | 277 | E>G | No | EVA | |
| rs3388931294 | 283 | R>S | No | EVA | |
| rs3388939306 | 284 | E>* | No | EVA | |
| rs3388941264 | 286 | E>V | No | EVA |
No associated diseases with Q8K0V2
1 regional properties for Q8K0V2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Potentiating neddylation domain | 86 - 278 | IPR005176 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| ubiquitin ligase complex | A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cullin family protein binding | Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). |
| ubiquitin conjugating enzyme binding | Binding to a ubiquitin conjugating enzyme, any of the E2 proteins. |
| ubiquitin-like protein binding | Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of cell growth | Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. |
| negative regulation of G1/S transition of mitotic cell cycle | Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. |
| negative regulation of protein neddylation | Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of protein neddylation | Any process that activates or increases the frequency, rate or extent of protein neddylation. |
| positive regulation of ubiquitin-protein transferase activity | Any process that activates, maintains or increases the rate of ubiquitin transferase activity. |
| protein neddylation | Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. |
| regulation of cell cycle process | Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. |
| regulation of protein neddylation | Any process that modulates the frequency, rate or extent of protein neddylation. |
| response to gamma radiation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. |
| response to UV-C | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9V1 | DCUN1D3 | DCN1-like protein 3 | Bos taurus (Bovine) | PR |
| Q8IWE4 | DCUN1D3 | DCN1-like protein 3 | Homo sapiens (Human) | PR |
| Q4V8B2 | Dcun1d3 | DCN1-like protein 3 | Rattus norvegicus (Rat) | PR |
| Q9U3C8 | dcn-1 | Defective in cullin neddylation protein 1 | Caenorhabditis elegans | PR |
| A4IHK8 | dcun1d3 | DCN1-like protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGQCVTKCKN | PSSTLGSKNG | DRDPSNKSHS | RRGASHREEQ | VPPCGKPAGD | ILVNGTKKAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AATEACQLPT | SSGDAGRESK | TNAEESSLQR | LEELFRRYKD | EREDAILEEG | MERFCNDLCV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DPTEFRVLLL | AWKFQAATMC | KFTRKEFFDG | CKAISADSID | GICARFPSLL | TEAKQEDKFK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLYRFTFQFG | LDSEEGQRSL | HREIAIALWK | LVFTQNNPPV | LDQWLNFLTE | NPSGIKGISR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DTWNMFLNFT | QVIGPDLSNY | SEDEAWPSLF | DTFVEWEMER | RKREVEGRGT | LSSGQEGLCP |
| EEQT |