Q9TTA5
PR
Gene name |
SMARCAL1 (HARP) |
Protein name |
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 |
Names |
HepA-related protein, Sucrose nonfermenting protein 2-like 1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:338072 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9TTA5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9TTA5-F1 | Predicted | AlphaFoldDB |
No variants for Q9TTA5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9TTA5 | |||||
No associated diseases with Q9TTA5
7 regional properties for Q9TTA5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 4 - 72 | IPR000504-1 |
| domain | RNA recognition motif domain | 154 - 229 | IPR000504-2 |
| domain | RNA recognition motif domain | 283 - 359 | IPR000504-3 |
| domain | RNA recognition motif domain | 401 - 478 | IPR000504-4 |
| domain | RNA recognition motif domain | 758 - 834 | IPR000504-5 |
| domain | RBM12B, RNA recognition motif 2 | 152 - 237 | IPR034588 |
| domain | RNA-binding protein 12B, RNA recognition motif 4 | 401 - 476 | IPR047188 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear replication fork | The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| ATP-dependent DNA/DNA annealing activity | An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule. |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| replication fork processing | The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes. |
| replication fork protection | Any process that prevents the collapse of stalled replication forks. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5FWF4 | ZRANB3 | DNA annealing helicase and endonuclease ZRANB3 | Homo sapiens (Human) | PR |
| Q9NZC9 | SMARCAL1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 | Homo sapiens (Human) | PR |
| Q8BJL0 | Smarcal1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 | Mus musculus (Mouse) | PR |
| B4F769 | Smarcal1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 | Rattus norvegicus (Rat) | PR |
| Q8MNV7 | smrc-1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog | Caenorhabditis elegans | PR |
| B2ZFP3 | smarcal1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSISPLKCPC | LLQRSRGKIE | ANRQKALARR | AEKLLAEQHQ | KPAQSKQGPS | QNLPRDPSKS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSHGIFFKQQ | NPSSSSHGDQ | RPQNPHSFSP | NTSEQAKGMW | QRPEEMPTAC | PSYRPPNQVT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VAGISPPLAN | SPPGVPSQQL | WGCELGQGHP | QASLETQSTP | FANTTHEPLA | KVKNFQETAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSCGQPPRDP | ELEARMARPS | TSGQNISGSV | MPRTEGRLQQ | KAGTPLHRVV | GSQQGRCIRN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GERFQVKIGY | NEALIAVFKS | LPSRSYDPAT | KTWNFSMTDY | GPLMKAAQRL | PGITLQPLEG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AEGHMESPST | SSGIIAKTGL | PAAPSLAFVK | GQCVLISRAR | FEADISYSED | LIALFKQMDS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RKYDVKTRKW | SFLLEEYSKL | MERVRGLPQV | QLDPLPKTLT | LFRAQLQKTS | LSPVADIPEA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DLSRVDSKLV | SSLLPFQRAG | VNFAIAQRGR | LLLADDMGLG | KTIQAICIAA | YYRKEWPLLV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VVPSSVRFTW | EQAFCRWLPS | LNPLDINVVV | TGKDRLTDGL | VNIVSFDLLS | KLEKQLKPPF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KVVIIDESHF | LKNIKTARCR | AAMPLLKVAK | RVILLSGTPA | MSRPAELYTQ | ILAVRPTFFP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QFHAFGLRYC | GAKRQPWGWD | YSGSSNLGEL | KLLLEEAVML | RRLKGDVLSQ | LPAKQARWWW |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SPQARSTPGP | EPPWMPPPRM | TTKDKTKQQQ | KEALILFFNR | TAEAKIPSII | EYILDLLESG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| REKFLVFAHH | KVVLDAITKE | LERKRVQHIR | IDGSTSSADR | ETSASSFSCP | RALRGVLSIT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AANMGLTFSS | ADLVVFGELF | WNPGVLMQAE | DRVHRIGQLS | SVSIHYLVAR | GTADDYLWPL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IQEKIKVLGE | AGLSETNFSE | MTEATDYFSK | DSKQQKIYNL | FQKSFEEDGN | DMELLEAAES |
| 910 | 920 | 930 | |||
| FDPGSQDTGD | KLDESTLTGS | PVKKKRFEFF | DNWDSFTSPL |