Q8MNV7

PR
Gene name
smrc-1
Protein name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C16A3.1
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-217 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8MNV7

Entry ID Method Resolution Chain Position Source
AF-Q8MNV7-F1 Predicted AlphaFoldDB

No variants for Q8MNV7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8MNV7

No associated diseases with Q8MNV7

4 regional properties for Q8MNV7

Type Name Position InterPro Accession
domain Signal transduction response regulator, receiver domain 715 - 833 IPR001789
domain GAF domain 269 - 423 IPR003018
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 447 - 514 IPR003661
domain Histidine kinase domain 456 - 690 IPR005467

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear replication fork The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
ATP-dependent DNA/DNA annealing activity An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule.
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

4 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
replication fork processing The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.
replication fork protection Any process that prevents the collapse of stalled replication forks.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9TTA5 SMARCAL1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Bos taurus (Bovine) PR
Q5FWF4 ZRANB3 DNA annealing helicase and endonuclease ZRANB3 Homo sapiens (Human) PR
Q9NZC9 SMARCAL1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Homo sapiens (Human) PR
Q8BJL0 Smarcal1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Mus musculus (Mouse) PR
B4F769 Smarcal1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Rattus norvegicus (Rat) PR
B2ZFP3 smarcal1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MVLTDEQRQA IAKKREEAIR RAAAYREREM QAAANATAST SSAAPPAPPK PVIPVMFSQN
70 80 90 100 110 120
RQNFQPMKPT MNNSTKQSTI NNYIKQVQKP EPTSLIKPTI GVKLKLDIGD RIKIEFYPFH
130 140 150 160 170 180
SAVIDLIKQV PSRNYDPAKR SWTVASSDHI TISNILKNAT AVKVELEPLP QNIIGLTNFK
190 200 210 220 230 240
PKAAPSDLNT VMDPSLIERL FPYQKEGVIF ALERDGRILL ADEMGLGKSV QALTIARYYK
250 260 270 280 290 300
ADWPLLIVCP ASVKGAWKKQ LNTFFPIIHR IFIVDKSSDP LPDVCTSNTV AIMSYEQMVL
310 320 330 340 350 360
KHDILKKEKY RTIIFDESHM LKDGKARRTK VATDLSKVAL HVILLSGTPA LSRPSELFTQ
370 380 390 400 410 420
IRLIDHKLFT NFHEFAIRYC DGKQGRFCFE AKGCTNSEEL AAIMFKRLMI RRLKADVLKD
430 440 450 460 470 480
LPEKRREVVY VSGPTIDARM DDLQKARADY EKVNSMERKH ESLLEFYSLT GIVKAAAVCE
490 500 510 520 530 540
HILENYFYPD APPRKVLIFA HHQIVLDTIQ VEVNKRKLGS IRIDGKTPSH RRTALCDSFQ
550 560 570 580 590 600
TDDNIRVAVL SITAAGVGIT LTAASVVVFA EIHFNPGYLV QAEDRAHRVG QKDSVFVQYL
610 620 630 640 650 660
IAKKTADDVM WNMVQQKLDV LGQVSLSSDT FRTADKMHLR FNDAAQPGIA EYLKKTPDTT
670 680
IDEWEDPVEE KEDDDLEIIC DSPAPKRIKN