B2ZFP3

PR
Gene name
smarcal1 (harp, si:ch211-239d11.1)
Protein name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Names
HepA-related protein, Sucrose nonfermenting protein 2-like 1
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:560412
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-153 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2ZFP3

Entry ID Method Resolution Chain Position Source
AF-B2ZFP3-F1 Predicted AlphaFoldDB

No variants for B2ZFP3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2ZFP3

No associated diseases with B2ZFP3

5 regional properties for B2ZFP3

Type Name Position InterPro Accession
domain SNF2, N-terminal 357 - 574 IPR000330
domain Helicase, C-terminal 614 - 773 IPR001650
domain HARP domain 127 - 198 IPR010003-1
domain HARP domain 231 - 302 IPR010003-2
domain Helicase superfamily 1/2, ATP-binding domain 335 - 525 IPR014001

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear replication fork The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
ATP-dependent DNA/DNA annealing activity An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule.
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

10 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cartilage development The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
embryonic body morphogenesis The process in which the anatomical structures of the embryonic soma are generated and organized.
hemopoiesis The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
replication fork processing The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.
replication fork protection Any process that prevents the collapse of stalled replication forks.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9TTA5 SMARCAL1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Bos taurus (Bovine) PR
Q5FWF4 ZRANB3 DNA annealing helicase and endonuclease ZRANB3 Homo sapiens (Human) PR
Q9NZC9 SMARCAL1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Homo sapiens (Human) PR
Q8BJL0 Smarcal1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Mus musculus (Mouse) PR
B4F769 Smarcal1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Rattus norvegicus (Rat) PR
Q8MNV7 smrc-1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog Caenorhabditis elegans PR
10 20 30 40 50 60
MSVSLTPEQQ RRIEENRKKA LARRAERQAQ IADPGPAQNK HTQSGTTGGP AKNNQHFASD
70 80 90 100 110 120
RGQSGAPTRQ TQLIDINAAC TKTAPPTSIT AASTASSFYG QAGKPSTGEK RPPKPPEPAA
130 140 150 160 170 180
NIPAKKPAVY LRGRCVSHSE NRFRVEVGYH ADLILVFKSI PSKNYDPATK MWNFSLEDYQ
190 200 210 220 230 240
MLMEQVAHLP SISLKPLEGM EGLNISASTC RPKDAAAMAA LMRLCQGWQK PGATIKGKCV
250 260 270 280 290 300
LVSRSRLEVD IGYQADVIGI FKQMPSKSYD MKTRKWTFLL EDYGKLMADL NELPTVETEP
310 320 330 340 350 360
LPHAVLQSFS SQFEKTQSQA PVPPEADLSH IDPQLTRSLM PFQRDGVNFA VSREGRLLLA
370 380 390 400 410 420
DDMGLGKTVQ AICIAAYYRS EWPLLVVAPS SVRFTWAEAF RRWLPSVKPD SINVVVKGKD
430 440 450 460 470 480
SLRSGLINII SYDLLNKMDK QPPSSPFNVI IMDESHFLKN MKTARCRAAL PLLKTAKRVI
490 500 510 520 530 540
LLSGTPAMSR PAELYTQIQA VRPALFPRFH DFGTRYCDAK QLPWGWDYSS SSNLTELKLL
550 560 570 580 590 600
LEESLMLRRL KSEVLSQLPA KQRKVVTVTT DGINSRTKAA LNAAARELAK GYHNKSQEKE
610 620 630 640 650 660
ALLVFFNHTA EAKIRAIMEY ISDMLECGRE KFLVFAHHKL VLDSITKELG EKSISFIRID
670 680 690 700 710 720
GSTPSAERQL LCERFQASQQ SCVAVLSITA ANMGLTLHSA ALVVFAELFW NPGVLIQAED
730 740 750 760 770 780
RVHRIGQTSN VDIHYLVAKG TADDYLWPMI QAKMNVLEQV GLSESNISEN AESASFHSRD
790 800
RQQLTITEMF QRSFDEDEML ALMDQDP