Q9STK6
Gene name |
WNK3 (At3g48260, T29H11_220) |
Protein name |
Probable serine/threonine-protein kinase WNK3 |
Names |
AtWNK3, Protein kinase with no lysine 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G48260 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
168-190 (Activation loop from InterPro)
Target domain |
22-280 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9STK6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9STK6-F1 | Predicted | AlphaFoldDB |
35 variants for Q9STK6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02468533 | 4 | D>E | No | 1000Genomes | |
| ENSVATH02468532 | 5 | E>D | No | 1000Genomes | |
| tmp_3_17875198_G_A | 8 | S>F | No | 1000Genomes | |
| tmp_3_17874829_A_G | 72 | V>A | No | 1000Genomes | |
| ENSVATH14399848 | 72 | V>F | No | 1000Genomes | |
| ENSVATH12633859 | 78 | L>V | No | 1000Genomes | |
| ENSVATH02468521 | 93 | H>Q | No | 1000Genomes | |
| ENSVATH14399847 | 122 | L>R | No | 1000Genomes | |
| ENSVATH14399845 | 242 | K>R | No | 1000Genomes | |
| ENSVATH14399804 | 244 | A>V | No | 1000Genomes | |
| tmp_3_17874062_T_G | 248 | N>H | No | 1000Genomes | |
| ENSVATH06268660 | 266 | S>T | No | 1000Genomes | |
| tmp_3_17874003_T_A | 267 | Q>H | No | 1000Genomes | |
| ENSVATH06268658 | 282 | C>W | No | 1000Genomes | |
| ENSVATH06268657 | 285 | E>A | No | 1000Genomes | |
| ENSVATH02468505 | 293 | H>L | No | 1000Genomes | |
| ENSVATH00407801 | 297 | G>C | No | 1000Genomes | |
| tmp_3_17873731_A_G | 307 | L>P | No | 1000Genomes | |
| tmp_3_17873722_G_C | 310 | S>C | No | 1000Genomes | |
| tmp_3_17873716_A_C | 312 | V>G | No | 1000Genomes | |
| ENSVATH02468492 | 318 | E>D | No | 1000Genomes | |
| ENSVATH02468493 | 318 | E>Q | No | 1000Genomes | |
| ENSVATH12633787 | 382 | T>I | No | 1000Genomes | |
| tmp_3_17873356_C_T | 403 | V>I | No | 1000Genomes | |
| tmp_3_17873257_G_A | 436 | R>C | No | 1000Genomes | |
| ENSVATH06268645 | 444 | N>S | No | 1000Genomes | |
| ENSVATH12633786 | 447 | L>F | No | 1000Genomes | |
| ENSVATH12633754 | 450 | A>S | No | 1000Genomes | |
| ENSVATH12633753 | 452 | G>R | No | 1000Genomes | |
| ENSVATH12633752 | 457 | E>D | No | 1000Genomes | |
| tmp_3_17873179_C_T | 462 | V>I | No | 1000Genomes | |
| tmp_3_17873164_A_T | 467 | S>T | No | 1000Genomes | |
| ENSVATH02468479 | 482 | D>N | No | 1000Genomes | |
| tmp_3_17873080_G_A | 495 | P>S | No | 1000Genomes | |
| ENSVATH02468478 | 513 | N>S | No | 1000Genomes |
No associated diseases with Q9STK6
8 regional properties for Q9STK6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 478 - 763 | IPR000719 |
| domain | S-locus glycoprotein domain | 198 - 305 | IPR000858 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 480 - 746 | IPR001245 |
| domain | Bulb-type lectin domain | 16 - 166 | IPR001480 |
| domain | PAN/Apple domain | 326 - 408 | IPR003609 |
| active_site | Serine/threonine-protein kinase, active site | 599 - 611 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 484 - 506 | IPR017441 |
| domain | S-locus receptor kinase, C-terminal | 750 - 792 | IPR021820 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
22 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UHY1 | NRBP1 | Nuclear receptor-binding protein | Homo sapiens (Human) | PR |
| Q9H4A3 | WNK1 | Serine/threonine-protein kinase WNK1 | Homo sapiens (Human) | SS |
| Q96J92 | WNK4 | Serine/threonine-protein kinase WNK4 | Homo sapiens (Human) | SS |
| Q9Y3S1 | WNK2 | Serine/threonine-protein kinase WNK2 | Homo sapiens (Human) | SS |
| Q9BYP7 | WNK3 | Serine/threonine-protein kinase WNK3 | Homo sapiens (Human) | SS |
| Q8TDX7 | NEK7 | Serine/threonine-protein kinase Nek7 | Homo sapiens (Human) | EV |
| Q80UE6 | Wnk4 | Serine/threonine-protein kinase WNK4 | Mus musculus (Mouse) | SS |
| Q99J45 | Nrbp1 | Nuclear receptor-binding protein | Mus musculus (Mouse) | PR |
| P83741 | Wnk1 | Serine/threonine-protein kinase WNK1 | Mus musculus (Mouse) | SS |
| Q3UH66 | Wnk2 | Serine/threonine-protein kinase WNK2 | Mus musculus (Mouse) | SS |
| Q80XP9 | Wnk3 | Serine/threonine-protein kinase WNK3 | Mus musculus (Mouse) | SS |
| Q6R2V0 | WNK1 | Serine/threonine-protein kinase WNK1 | Sus scrofa (Pig) | SS |
| Q7TPK6 | Wnk4 | Serine/threonine-protein kinase WNK4 | Rattus norvegicus (Rat) | SS |
| Q9JIH7 | Wnk1 | Serine/threonine-protein kinase WNK1 | Rattus norvegicus (Rat) | EV |
| P59895 | Nek6 | Serine/threonine-protein kinase Nek6 | Rattus norvegicus (Rat) | SS |
| D3ZBE5 | Nek7 | Serine/threonine-protein kinase Nek7 | Rattus norvegicus (Rat) | SS |
| G5EFM9 | nekl-3 | Serine/threonine-protein kinase nekl-3 | Caenorhabditis elegans | PR |
| X5M5N0 | wnk-1 | Serine/threonine-protein kinase WNK | Caenorhabditis elegans | SS |
| Q8RXE5 | WNK10 | Probable serine/threonine-protein kinase WNK10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944Q0 | WNK8 | Serine/threonine-protein kinase WNK8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVL5 | WNK4 | Probable serine/threonine-protein kinase WNK4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LST2 | WNK7 | Probable serine/threonine-protein kinase WNK7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRQDENNSEE | EFVEIDPTGR | YGRYKEVLGK | GAFKEVYRAF | DQLEGIEVAW | NQVKLDDKFC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSEDLDRLYS | EVHLLKTLKH | KSIIKFYTSW | IDHQHMTINL | ITEVFTSGNL | RQYRKKHKCV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLRALKKWSR | QILEGLVYLH | SHDPPVIHRD | LKCDNIFING | NQGEVKIGDL | GLAAILHRAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SAHSVIGTPE | FMAPELYEED | YNVLVDIYAF | GMCLLELVTF | EYPYSECTNA | AQIYRKVTSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IKPAALLNVT | DPQVRAFIEK | CIAKVSQRLS | AKELLDDPFL | KCYKENTENV | SSHKENGYNG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NGIVDKLSDS | EVGLLTVEGQ | RKDLNTIFLK | LRITDSKGQI | RNIHFPFNIE | TDTSFSVAIE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MVEELDLTDD | QDISTIAKMI | DTEIHSHIPD | WTPSRLIGDD | SAVQKCLSSP | ETLHLDRFPS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GRKFWSSPKA | GAGDSRSPFA | PRSNSKLSSA | QGPINQEVGV | IVEKLESLLR | KQREEIEEMQ |
| 490 | 500 | 510 | |||
| RDQERIVTEF | LKEFPPEICE | EALVRLQVKD | SDNLLC |