Q8RXE5

PR
Gene name
WNK10 (At1g64630, F1N19.20)
Protein name
Probable serine/threonine-protein kinase WNK10
Names
AtWNK10, Protein kinase with no lysine 10
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G64630
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

245-524 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

162-183 (Activation loop from InterPro)

Target domain

16-273 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8RXE5

Entry ID Method Resolution Chain Position Source
AF-Q8RXE5-F1 Predicted AlphaFoldDB

66 variants for Q8RXE5

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05060145 7 V>A No 1000Genomes
ENSVATH05060150 19 N>I No 1000Genomes
tmp_1_24020152_C_T 29 T>I No 1000Genomes
ENSVATH05060154 31 Y>F No 1000Genomes
tmp_1_24020327_A_C 49 I>L No 1000Genomes
ENSVATH13724356 94 M>V No 1000Genomes
ENSVATH13724357 96 T>I No 1000Genomes
ENSVATH05060159 98 L>F No 1000Genomes
ENSVATH05060159 98 L>V No 1000Genomes
ENSVATH05060161 102 G>V No 1000Genomes
tmp_1_24020498_C_T 106 L>F No 1000Genomes
ENSVATH05060163 111 H>L No 1000Genomes
ENSVATH01463210 112 R>C No 1000Genomes
ENSVATH00120890 112 R>H No 1000Genomes
tmp_1_24020644_G_A 120 M>I No 1000Genomes
tmp_1_24020661_T_G 126 I>S No 1000Genomes
tmp_1_24020724_G_T 147 C>F No 1000Genomes
ENSVATH05060164 158 K>E No 1000Genomes
ENSVATH14411205 167 A>T No 1000Genomes
ENSVATH05060166 178 V>L No 1000Genomes
tmp_1_24020912_C_T 181 T>I No 1000Genomes
ENSVATH14411206 191 E>K No 1000Genomes
ENSVATH05060170 195 N>T No 1000Genomes
ENSVATH05060172 216 P>S No 1000Genomes
tmp_1_24021034_A_T 222 N>Y No 1000Genomes
tmp_1_24021038_A_T 223 Q>L No 1000Genomes
ENSVATH01463215 240 S>I No 1000Genomes
ENSVATH14411209 249 Q>H No 1000Genomes
ENSVATH05060177 253 K>N No 1000Genomes
tmp_1_24021228_C_G 260 S>C No 1000Genomes
tmp_1_24021270_C_T 274 A>V No 1000Genomes
tmp_1_24021315_C_G 289 T>R No 1000Genomes
ENSVATH13724364 295 M>R No 1000Genomes
ENSVATH00120893 299 C>S No 1000Genomes
tmp_1_24021353_C_T 302 R>C No 1000Genomes
ENSVATH01463216 307 E>D No 1000Genomes
ENSVATH01463217 308 Y>H No 1000Genomes
ENSVATH13724365 313 S>R No 1000Genomes
ENSVATH13724366 314 V>I No 1000Genomes
ENSVATH13724367 316 I>T No 1000Genomes
tmp_1_24021395_A_G 316 I>V No 1000Genomes
tmp_1_24021404_T_G 319 S>A No 1000Genomes
tmp_1_24021428_G_A 327 A>T No 1000Genomes
ENSVATH05060182 357 M>T No 1000Genomes
ENSVATH14411210 360 R>Q No 1000Genomes
ENSVATH01463219 378 K>N No 1000Genomes
ENSVATH13724371 379 T>I No 1000Genomes
ENSVATH05060185 394 D>N No 1000Genomes
ENSVATH05060186 401 T>I No 1000Genomes
ENSVATH14411211 407 I>T No 1000Genomes
ENSVATH00120895 425 S>R No 1000Genomes
ENSVATH05060187 426 V>L No 1000Genomes
ENSVATH05060188 445 D>E No 1000Genomes
tmp_1_24021885_G_A 449 R>Q No 1000Genomes
ENSVATH05060189 450 V>I No 1000Genomes
tmp_1_24021925_C_G 462 C>W No 1000Genomes
ENSVATH00120896 464 A>T No 1000Genomes
ENSVATH05060191 474 D>V No 1000Genomes
ENSVATH05060192 475 S>L No 1000Genomes
ENSVATH00120897 481 N>D No 1000Genomes
tmp_1_24021982_C_A 481 N>K No 1000Genomes
ENSVATH00120898 493 V>M No 1000Genomes
tmp_1_24022035_A_G 499 N>S No 1000Genomes
tmp_1_24022046_C_T 503 Q>* No 1000Genomes
tmp_1_24022055_C_T 506 L>F No 1000Genomes
ENSVATH05060196 508 M>L No 1000Genomes

No associated diseases with Q8RXE5

6 regional properties for Q8RXE5

Type Name Position InterPro Accession
domain C2 domain 1 - 116 IPR000008
domain HECT domain 564 - 918 IPR000569
domain WW domain 345 - 378 IPR001202-1
domain WW domain 377 - 410 IPR001202-2
domain WW domain 452 - 485 IPR001202-3
domain WW domain 492 - 525 IPR001202-4

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UHY1 NRBP1 Nuclear receptor-binding protein Homo sapiens (Human) PR
Q9H4A3 WNK1 Serine/threonine-protein kinase WNK1 Homo sapiens (Human) SS
Q96J92 WNK4 Serine/threonine-protein kinase WNK4 Homo sapiens (Human) SS
Q9Y3S1 WNK2 Serine/threonine-protein kinase WNK2 Homo sapiens (Human) SS
Q9BYP7 WNK3 Serine/threonine-protein kinase WNK3 Homo sapiens (Human) SS
Q80UE6 Wnk4 Serine/threonine-protein kinase WNK4 Mus musculus (Mouse) SS
Q99J45 Nrbp1 Nuclear receptor-binding protein Mus musculus (Mouse) PR
P83741 Wnk1 Serine/threonine-protein kinase WNK1 Mus musculus (Mouse) SS
Q3UH66 Wnk2 Serine/threonine-protein kinase WNK2 Mus musculus (Mouse) SS
Q80XP9 Wnk3 Serine/threonine-protein kinase WNK3 Mus musculus (Mouse) SS
Q6R2V0 WNK1 Serine/threonine-protein kinase WNK1 Sus scrofa (Pig) SS
Q7TPK6 Wnk4 Serine/threonine-protein kinase WNK4 Rattus norvegicus (Rat) SS
Q9JIH7 Wnk1 Serine/threonine-protein kinase WNK1 Rattus norvegicus (Rat) EV
X5M5N0 wnk-1 Serine/threonine-protein kinase WNK Caenorhabditis elegans SS
Q944Q0 WNK8 Serine/threonine-protein kinase WNK8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVL5 WNK4 Probable serine/threonine-protein kinase WNK4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STK6 WNK3 Probable serine/threonine-protein kinase WNK3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LST2 WNK7 Probable serine/threonine-protein kinase WNK7 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEEADFVQKD PTGRYIRYND VLGRGAFKTV YKAFDEVEGI EVAWNLMSIE DVLQMPGQLD
70 80 90 100 110 120
RLYSEVHLLN SLKHDNIIKL FYSWVDDHNK SINMITELFT SGSLTLYRKK HRKVDPKAIM
130 140 150 160 170 180
NWARQILKGL HYLHSQTPPV IHRDLKCDNI FVNGNTGKVK IGDLGLAAVM QQPTARSVIG
190 200 210 220 230 240
TPEFMAPELY EEEYNELVDI YSFGMCMLEM VTCEYPYREC RNQAQIYKKV TSGIKPQSLS
250 260 270 280 290 300
KVDDPQVKQF IEKCLLPAPS RPTALELLKD QLLAVDGAKD STLTASSNTT FKPAMPPQCE
310 320 330 340 350 360
YRPMDVEYKK NTSVSICSSA KSSQECALLQ TMEVQRVAES TEFKLSGERR DDVAASMALR
370 380 390 400 410 420
IAGSSGQARK VDFDFNLKTD TARAVTGEMV EELDLSSHEV TVIAEMIDEL IMKLKANRSL
430 440 450 460 470 480
PNANSVYQSK DEEAGESMKS EISADYYHRV SSNEGSRLGC CCEAVESLLS SFLDSCSMVS
490 500 510 520
NKQSEDLKTE LNVIESQYNQ SCQRLLRMKE EAIEKAKRKW MKLS