AiPD: Autoinhibited Protein Database

Gene name	WNK7 (At1g49160, F27J15.7)
Protein name	Probable serine/threonine-protein kinase WNK7
Names	AtWNK7, Protein kinase with no lysine 7
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G49160
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

316-404 (Predicted disordered autoinhibitory region) PR

316-404 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8LST2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH01326534	4	S>P	No	1000Genomes
tmp_1_18181845_G_C	8	S>C	No	1000Genomes
tmp_1_18181842_G_A	9	A>V	No	1000Genomes
ENSVATH04912033	29	R>W	No	1000Genomes
tmp_1_18181359_G_A	80	L>F	No	1000Genomes
ENSVATH04912022	101	N>S	No	1000Genomes
tmp_1_18181278_T_C	107	I>V	No	1000Genomes
ENSVATH04912019	135	A>G	No	1000Genomes
tmp_1_18181090_C_T	136	R>K	No	1000Genomes
tmp_1_18180945_T_A	184	Q>H	No	1000Genomes
tmp_1_18180750_C_T	217	M>I	No	1000Genomes
ENSVATH04912013	226	E>D	No	1000Genomes
ENSVATH04912009	251	L>V	No	1000Genomes
tmp_1_18180403_G_A	295	P>S	No	1000Genomes
tmp_1_18180390_G_A	299	P>L	No	1000Genomes
tmp_1_18180375_G_A	304	P>L	No	1000Genomes
tmp_1_18180333_C_T	318	G>E	No	1000Genomes
tmp_1_18180328_G_A	320	P>S	No	1000Genomes
tmp_1_18180297_T_G	330	N>T	No	1000Genomes
tmp_1_18180292_C_T	332	D>N	No	1000Genomes
ENSVATH04912006	343	S>R	No	1000Genomes
ENSVATH13458123	347	G>E	No	1000Genomes
ENSVATH00089040	349	N>K	No	1000Genomes
tmp_1_18180206_G_T	360	N>K	No	1000Genomes
ENSVATH14267537	385	G>E	No	1000Genomes
ENSVATH01326520	403	N>T	No	1000Genomes
ENSVATH14267536	442	A>T	No	1000Genomes
tmp_1_18179765_T_A	461	N>I	No	1000Genomes
tmp_1_18179763_C_A	462	G>C	No	1000Genomes
tmp_1_18179742_C_T	469	E>K	No	1000Genomes
tmp_1_18179708_C_T	480	C>Y	No	1000Genomes
tmp_1_18179703_G_C	482	R>G	No	1000Genomes
ENSVATH04912002	491	V>L	No	1000Genomes
tmp_1_18179666_G_T	494	T>K	No	1000Genomes
ENSVATH04912001	503	P>L	No	1000Genomes
ENSVATH01326519	513	E>D	No	1000Genomes
ENSVATH04912000	516	K>T	No	1000Genomes
ENSVATH14267535	541	T>K	No	1000Genomes
tmp_1_18179503_A_T	548	F>L	No	1000Genomes
tmp_1_18179499_C_G	550	E>Q	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	28 - 285	IPR000719
active_site	Serine/threonine-protein kinase, active site	152 - 164	IPR008271

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Name	Definition
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation	The process of introducing a phosphate group on to a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q96J92	WNK4	Serine/threonine-protein kinase WNK4	Homo sapiens (Human)	SS
Q9BYP7	WNK3	Serine/threonine-protein kinase WNK3	Homo sapiens (Human)	SS
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	Homo sapiens (Human)	SS
Q9Y3S1	WNK2	Serine/threonine-protein kinase WNK2	Homo sapiens (Human)	SS
Q9UHY1	NRBP1	Nuclear receptor-binding protein	Homo sapiens (Human)	PR
P83741	Wnk1	Serine/threonine-protein kinase WNK1	Mus musculus (Mouse)	SS
Q3UH66	Wnk2	Serine/threonine-protein kinase WNK2	Mus musculus (Mouse)	SS
Q80UE6	Wnk4	Serine/threonine-protein kinase WNK4	Mus musculus (Mouse)	SS
Q80XP9	Wnk3	Serine/threonine-protein kinase WNK3	Mus musculus (Mouse)	SS
Q99J45	Nrbp1	Nuclear receptor-binding protein	Mus musculus (Mouse)	PR
Q6R2V0	WNK1	Serine/threonine-protein kinase WNK1	Sus scrofa (Pig)	SS
Q7TPK6	Wnk4	Serine/threonine-protein kinase WNK4	Rattus norvegicus (Rat)	SS
Q9JIH7	Wnk1	Serine/threonine-protein kinase WNK1	Rattus norvegicus (Rat)	EV
E9PTG8	Stk10	Serine/threonine-protein kinase 10	Rattus norvegicus (Rat)	PR
X5M5N0	wnk-1	Serine/threonine-protein kinase WNK	Caenorhabditis elegans	SS
Q8RXE5	WNK10	Probable serine/threonine-protein kinase WNK10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q944Q0	WNK8	Serine/threonine-protein kinase WNK8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LVL5	WNK4	Probable serine/threonine-protein kinase WNK4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9STK6	WNK3	Probable serine/threonine-protein kinase WNK3	Arabidopsis thaliana (Mouse-ear cress)	PR