Q9SRU7
Gene name |
At3g02320 (F11A12.1, F11A12_100, F14P3.2) |
Protein name |
Probable tRNA (guanine(26)-N(2))-dimethyltransferase 2 |
Names |
tRNA 2,2-dimethylguanosine-26 methyltransferase 2, tRNA(guanine-26,N(2)-N(2)) methyltransferase 2, tRNA(m(2,2)G26)dimethyltransferase 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G02320 |
EC number |
2.1.1.216: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SRU7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SRU7-F1 | Predicted | AlphaFoldDB |
47 variants for Q9SRU7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_470127_A_G | 11 | I>V | No | 1000Genomes | |
| ENSVATH13858456 | 12 | K>E | No | 1000Genomes | |
| ENSVATH05757092 | 30 | K>R | No | 1000Genomes | |
| tmp_3_470701_A_T | 34 | N>I | No | 1000Genomes | |
| tmp_3_470714_G_C | 38 | M>I | No | 1000Genomes | |
| tmp_3_470722_C_T | 41 | A>V | No | 1000Genomes | |
| ENSVATH00302121 | 43 | L>I | No | 1000Genomes | |
| ENSVATH00302123 | 59 | S>F | No | 1000Genomes | |
| ENSVATH10456458 | 71 | K>N | No | 1000Genomes | |
| ENSVATH00302124 | 76 | A>D | No | 1000Genomes | |
| ENSVATH00302125 | 79 | E>K | No | 1000Genomes | |
| ENSVATH00302126 | 80 | E>G | No | 1000Genomes | |
| tmp_3_470847_A_G | 83 | S>G | No | 1000Genomes | |
| ENSVATH05757104 | 119 | P>S | No | 1000Genomes | |
| ENSVATH00302127 | 139 | A>V | No | 1000Genomes | |
| tmp_3_471149_A_G | 153 | N>D | No | 1000Genomes | |
| ENSVATH00302128 | 166 | K>Q | No | 1000Genomes | |
| ENSVATH05757111 | 180 | H>L | No | 1000Genomes | |
| ENSVATH05757112 | 190 | H>Y | No | 1000Genomes | |
| ENSVATH05757116 | 242 | S>F | No | 1000Genomes | |
| tmp_3_471912_G_T | 275 | R>L | No | 1000Genomes | |
| tmp_3_472134_G_C | 312 | V>L | No | 1000Genomes | |
| tmp_3_472161_T_A | 321 | F>I | No | 1000Genomes | |
| tmp_3_472165_A_G | 322 | H>R | No | 1000Genomes | |
| tmp_3_472479_C_T | 344 | P>L | No | 1000Genomes | |
| ENSVATH05757129 | 349 | D>N | No | 1000Genomes | |
| ENSVATH05757131 | 380 | S>R | No | 1000Genomes | |
| ENSVATH05757138 | 429 | A>T | No | 1000Genomes | |
| ENSVATH13858464 | 432 | R>* | No | 1000Genomes | |
| tmp_3_472854_A_T | 439 | N>Y | No | 1000Genomes | |
| ENSVATH13858475 | 459 | E>D | No | 1000Genomes | |
| ENSVATH00302131 | 471 | N>D | No | 1000Genomes | |
| tmp_3_473217_C_T | 499 | R>C | No | 1000Genomes | |
| tmp_3_473253_A_G | 511 | K>E | No | 1000Genomes | |
| tmp_3_473327_C_G | 535 | S>R | No | 1000Genomes | |
| ENSVATH00302133 | 539 | S>T | No | 1000Genomes | |
| tmp_3_473361_A_T | 547 | N>Y | No | 1000Genomes | |
| ENSVATH05757144 | 548 | G>S | No | 1000Genomes | |
| ENSVATH05757146 | 553 | H>R | No | 1000Genomes | |
| ENSVATH05757145 | 553 | H>Y | No | 1000Genomes | |
| tmp_3_473388_G_A | 556 | E>K | No | 1000Genomes | |
| tmp_3_473445_G_C | 575 | D>H | No | 1000Genomes | |
| tmp_3_473449_C_G | 576 | P>R | No | 1000Genomes | |
| ENSVATH05757147 | 576 | P>S | No | 1000Genomes | |
| ENSVATH10456508 | 587 | T>S | No | 1000Genomes | |
| tmp_3_473484_T_C | 588 | S>P | No | 1000Genomes | |
| ENSVATH05757148 | 589 | T>R | No | 1000Genomes |
No associated diseases with Q9SRU7
No regional properties for Q9SRU7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9SRU7 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.216 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (guanine-N2-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. |
| tRNA binding | Binding to a transfer RNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. |
| tRNA N2-guanine methylation | The process whereby a guanine in a tRNA is methylated at the N2 position of guanine. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q7Z2T5 | TRMT1L | TRMT1-like protein | Homo sapiens (Human) | PR |
| Q9NXH9 | TRMT1 | tRNA (guanine(26)-N(2))-dimethyltransferase | Homo sapiens (Human) | PR |
| Q3TX08 | Trmt1 | tRNA (guanine(26)-N(2))-dimethyltransferase | Mus musculus (Mouse) | PR |
| Q9LFU5 | At5g15810 | Probable tRNA (guanine(26)-N(2))-dimethyltransferase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METDLNDYTV | IKEGEAEILM | HKKNQVFFNK | AQVNNRDMSI | AVLREFLSKR | KQEHEAKSSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTRPASKVIE | KDASEASKEE | TPSENGMNNG | DHEVASEDGP | SSVSKDPAKT | TERFAPREPK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PPKVLEALSA | SGLRALRYAR | EIEGIGQVVA | LDNDLASVEA | CQRNIKFNGS | VAISKVESHH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TDARVHMLTH | PKEFDVVDLD | PYGSPSIFLD | SAIQSVTDGG | LLMCTATDMA | VLCGGNGEVC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YSKYGSYPLR | AKYCHEMALR | ILLASIESHA | NRYKRYIVPV | LSVQMDFYVR | VFVRVYTSAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AMKNTPLKLS | YVYQCIGCDS | FHLQPVGRSL | PKNNSVRYLP | AIGPVVKQDC | NHCGKKYNMG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GPIWSAPMHD | PEWVTSILNS | VKSMKDRYPA | YDRISAVLTT | VSEELLDVPL | FLSLHNLCAT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKCISPSAAM | FRSAVINANY | RISGTHVNPL | GMKTDAPMEV | IWDIMRCWVK | NHPIKAQSPE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QPGSVILSKE | PSHEVDFSRH | IGSLSKAQAK | KVARFLPNPE | KHWGPKLRAG | RQITSKHVSL |
| 550 | 560 | 570 | 580 | ||
| IGHEAVNGHL | SQHHEELKEE | DEEAEPEDNV | QDKVDPKRQK | TATDNITST |