AiPD: Autoinhibited Protein Database

Q7Z2T5

Gene name	TRMT1L (C1orf25, TRM1L, MSTP070)
Protein name	TRMT1-like protein
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:81627
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-100 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

30-100 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q7Z2T5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7Z2T5-F1	Predicted				AlphaFoldDB

491 variants for Q7Z2T5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA1289503 rs201874064	2	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA343882890 rs1172560092	2	E>D		No	ClinGen gnomAD
rs752695460 CA1289504	2	E>K		No	ClinGen ExAC TOPMed gnomAD
CA343882903 rs201874064	2	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1289502 rs368113240	3	N>K		No	ClinGen ExAC TOPMed gnomAD
CA343882867 rs1345917491	3	N>T		No	ClinGen TOPMed
rs753656594 CA1289501	5	A>V		No	ClinGen ExAC gnomAD
CA1289499 rs761966868	8	E>K		No	ClinGen ExAC TOPMed gnomAD
rs774596700 CA1289498	9	L>P		No	ClinGen ExAC TOPMed gnomAD
CA1289497 rs764089275	11	P>S		No	ClinGen ExAC gnomAD
rs762959096 CA1289496	12	L>M		No	ClinGen ExAC gnomAD
rs776031606 CA1289495	12	L>R		No	ClinGen ExAC gnomAD
rs1342475542 CA343882451	13	E>Q		No	ClinGen gnomAD
rs770277883 CA1289494	14	K>E		No	ClinGen ExAC gnomAD
CA343882368 rs1339407087	16	E>K		No	ClinGen gnomAD
rs998154164 CA33389748	17	V>G		No	ClinGen TOPMed
CA1289492 rs746269428	17	V>M		No	ClinGen ExAC gnomAD
rs902097627 CA33389745	18	E>K		No	ClinGen TOPMed gnomAD
rs776836061 CA1289490	19	V>A		No	ClinGen ExAC
rs1009436376 CA33389739	20	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs189413479 CA1289489	21	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1289487 rs777417475	23	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs758040414 CA1289486	24	V>F		No	ClinGen ExAC TOPMed gnomAD
rs892414003 CA343882043	25	P>Q		No	ClinGen gnomAD
CA33389726 rs892414003	25	P>R		No	ClinGen gnomAD
CA1289485 rs747658286	27	P>L		No	ClinGen ExAC TOPMed gnomAD
CA343881932 rs747658286	27	P>R		No	ClinGen ExAC TOPMed gnomAD
CA343881955 rs1444067739	27	P>S		No	ClinGen gnomAD
CA1289484 rs779034576	28	A>T		No	ClinGen ExAC gnomAD
CA343881890 rs904062733	29	R>G		No	ClinGen TOPMed gnomAD
rs754946753 CA1289483	29	R>P		No	ClinGen ExAC gnomAD
CA33389708 rs904062733	29	R>W		No	ClinGen TOPMed gnomAD
CA1289482 rs753782690	30	D>Y		No	ClinGen ExAC gnomAD
rs1246269976 CA343881783	32	A>S		No	ClinGen TOPMed gnomAD
rs1305333366 CA343881756	32	A>V		No	ClinGen TOPMed
rs755875052 CA1289480	33	G>R		No	ClinGen ExAC gnomAD
CA1289479 rs751738994	34	V>G		No	ClinGen ExAC gnomAD
rs1287053090 CA343881701	34	V>I		No	ClinGen gnomAD
CA343881608 rs1310224880	36	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs763084043 CA1289476	37	P>L		No	ClinGen ExAC TOPMed gnomAD
rs764360827 CA1289477	37	P>S		No	ClinGen ExAC TOPMed gnomAD
rs765780063 CA1289473	39	P>A		No	ClinGen ExAC gnomAD
rs1181417119 CA343881510	39	P>R		No	ClinGen gnomAD
CA1289474 rs765780063	39	P>S		No	ClinGen ExAC gnomAD
CA343881491 rs1253786086	40	D>N		No	ClinGen gnomAD
CA1289472 rs760056831	41	S>A		No	ClinGen ExAC gnomAD
CA343881409 rs777155352	43	L>M		No	ClinGen ExAC gnomAD
rs771204230 CA1289470	43	L>Q		No	ClinGen ExAC gnomAD
rs1226141806 CA343881359	44	D>H		No	ClinGen TOPMed
TCGA novel	45	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343881250 rs1406856412	46	A>V		No	ClinGen gnomAD
CA343881175 rs1290602644	48	T>I		No	ClinGen gnomAD
rs772807778 CA1289467	49	P>S		No	ClinGen ExAC gnomAD
CA1289466 rs771820572	51	S>L		No	ClinGen ExAC gnomAD
rs932744924 CA33389667	52	A>T		No	ClinGen Ensembl
rs1158509653 CA343881046	53	P>A		No	ClinGen gnomAD
CA1289465 rs370732709	54	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs778590946 CA1289464	55	P>A		No	ClinGen ExAC TOPMed gnomAD
rs199956086 CA1289463	56	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs199956086 CA343880875	56	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1571364614 CA343880834	57	P>R		No	ClinGen Ensembl
rs1471166193 CA343880866	57	P>S		No	ClinGen TOPMed
rs749190997 CA1289461	58	A>T		No	ClinGen ExAC gnomAD
CA343880739 rs755915918	59	L>P		No	ClinGen ExAC gnomAD
CA1289459 rs755915918	59	L>R		No	ClinGen ExAC gnomAD
rs1571364577 CA343880701	60	A>S		No	ClinGen Ensembl
CA1289458 rs750224358	60	A>V		No	ClinGen ExAC gnomAD
rs1330461015 CA343880645	61	Q>R		No	ClinGen gnomAD
CA1289457 rs777894296	62	A>T		No	ClinGen ExAC gnomAD
rs758595229 CA1289456	62	A>V		No	ClinGen ExAC gnomAD
rs765330105 CA33389637	63	P>A		No	ClinGen ExAC TOPMed gnomAD
rs765330105 CA1289454	63	P>S		No	ClinGen ExAC TOPMed gnomAD
CA1289453 rs759545650	64	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1390894048 CA343880469	66	S>C		No	ClinGen gnomAD
CA33389624 rs868246980	67	P>A		No	ClinGen TOPMed gnomAD
CA343880441 rs1413832935	67	P>R		No	ClinGen TOPMed gnomAD
CA343880368 rs1197354607	68	S>F		No	ClinGen gnomAD
rs1174052925 CA343880366	69	L>V		No	ClinGen TOPMed gnomAD
rs147387711 CA1289449	71	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs147387711 CA343880229	71	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs773605511 CA1289448	72	A>P		No	ClinGen ExAC TOPMed gnomAD
CA1289446 rs761591548	73	P>R		No	ClinGen ExAC TOPMed gnomAD
CA343880110 rs1202086354	75	E>V		No	ClinGen TOPMed
rs144761784 CA1289445	76	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA33389609 rs752960639	78	S>T		No	ClinGen TOPMed gnomAD
rs1223849471 CA343878352	80	R>K		No	ClinGen TOPMed
rs766845969 CA1289429	82	I>V		No	ClinGen ExAC TOPMed gnomAD
CA343878245 rs1213022796	84	I>T		No	ClinGen TOPMed
rs1163503159 CA343878249	84	I>V		No	ClinGen gnomAD
rs1415307306 CA343878206	86	R>K		No	ClinGen gnomAD
CA343878188 rs1330348244	87	Q>P		No	ClinGen TOPMed gnomAD
rs762206752 CA1289425	91	L>V		No	ClinGen ExAC TOPMed gnomAD
rs774200818 COSM1337085 CA1289424	92	E>D	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs962135877 CA33388613	92	E>K		No	ClinGen Ensembl
CA343878113 rs1183255357	93	N>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA343878105 rs1481759542	93	N>S		No	ClinGen gnomAD
rs1221078890 CA343878020	99	D>G		No	ClinGen gnomAD
rs1322446858 CA343878006	100	G>E		No	ClinGen gnomAD
rs1226561309 CA343877981	102	F>V		No	ClinGen gnomAD
rs1288758182 CA343877946	103	D>Y		No	ClinGen gnomAD
rs1392881773 CA343877915	105	A>G		No	ClinGen gnomAD
CA343877912 rs1365081992	106	S>G		No	ClinGen gnomAD
CA1289420 rs769139860	108	L>S		No	ClinGen ExAC gnomAD
TCGA novel rs776486368 CA1289419	113	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
CA1289418 rs776486368	113	L>P		No	ClinGen ExAC gnomAD
rs1456113400 CA343877792	115	A>S		No	ClinGen gnomAD
rs1456113400 CA343877788	115	A>T		No	ClinGen gnomAD
TCGA novel	115	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763892233 CA1289399	116	G>D		No	ClinGen ExAC gnomAD
CA343876635 rs200467304	117	N>K		No	ClinGen ExAC TOPMed gnomAD
rs139038962 CA1289395	118	R>S		No	ClinGen ESP ExAC gnomAD
rs375860895 CA1289393	120	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA1289392 rs375860895	120	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA343876516 rs1255194015	120	A>V		No	ClinGen gnomAD
rs78652979 CA1289391	121	C>F		No	ClinGen ExAC gnomAD
rs78652979 CA33388249	121	C>Y		No	ClinGen ExAC gnomAD
CA1289389 rs780078406	122	P>A		No	ClinGen ExAC gnomAD
CA1289387 rs756271493	122	P>Q		No	ClinGen ExAC gnomAD
rs780078406 CA1289388	122	P>S		No	ClinGen ExAC gnomAD
rs780078406 CA1289390	122	P>T		No	ClinGen ExAC gnomAD
CA1289384 rs745934308	123	L>F		No	ClinGen ExAC gnomAD
rs752067642 CA1289383	124	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
TCGA novel	124	C>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1289382 rs752067642	124	C>W		No	ClinGen ExAC
rs1400611770 CA343876228	125	P>L		No	ClinGen gnomAD
CA1289380 rs373143474	125	P>S		No	ClinGen ESP ExAC gnomAD
rs373143474 CA1289379	125	P>T		No	ClinGen ESP ExAC gnomAD
CA1289378 rs764784262	126	K>E		No	ClinGen ExAC TOPMed gnomAD
CA1289377 rs764784262	126	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA1289376 rs759114325	128	K>N		No	ClinGen ExAC gnomAD
CA1289375 rs753323072	129	F>I		No	ClinGen ExAC gnomAD
TCGA novel	131	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343875974 rs1166994865	131	A>P		No	ClinGen gnomAD
CA1289374 rs370739293	132	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA33388222 rs79681782	133	N>I		No	ClinGen TOPMed gnomAD
CA33388224 rs79681782	133	N>S		No	ClinGen TOPMed gnomAD
CA1289373 rs760635408	134	S>G		No	ClinGen ExAC gnomAD
rs151195858 CA33388218	134	S>R		No	ClinGen ESP TOPMed gnomAD
rs940198509 CA33388216	135	H>Y		No	ClinGen gnomAD
CA1289371 rs771911995	137	L>F		No	ClinGen ExAC gnomAD
CA1289370 rs368376702	138	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1486552977 CA343875683	138	R>H		No	ClinGen TOPMed gnomAD
CA1289369 rs775844209	139	R>C		No	ClinGen ExAC gnomAD
CA343875669 rs1176091618	139	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1378895035 CA343875610	140	H>L		No	ClinGen TOPMed
CA343875495 rs1455517592	143	N>K		No	ClinGen TOPMed
CA1289368 rs769880740	146	W>C		No	ClinGen ExAC
TCGA novel	156	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs915813047 CA343873461	159	I>L		No	ClinGen TOPMed gnomAD
CA33387462 rs915813047	159	I>V		No	ClinGen TOPMed gnomAD
CA343873389 rs1234366672	161	H>Q		No	ClinGen TOPMed gnomAD
CA343873400 rs1379989193	161	H>R		No	ClinGen TOPMed
rs1196392876 CA343873344	163	P>L		No	ClinGen gnomAD
CA33387460 rs974354008	163	P>T		No	ClinGen TOPMed
TCGA novel	163	P>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1289345 rs771150176	166	P>S		No	ClinGen ExAC gnomAD
CA1289342 rs112100541	169	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs200939961 CA1289343	169	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs200939961 CA33387451	169	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1571355953 CA343873093	175	Q>*		No	ClinGen Ensembl
rs1346849261 CA343872844	176	I>V		No	ClinGen gnomAD
CA343872816 rs1380165029	178	S>C		No	ClinGen gnomAD
rs1413745686 CA343872786	180	M>T		No	ClinGen gnomAD
CA1289328 rs762780477	181	G>E		No	ClinGen ExAC gnomAD
rs766704960 CA1289327	182	A>S		No	ClinGen ExAC TOPMed gnomAD
rs766704960 CA1289326	182	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1447267617 CA343872770	182	A>V		No	ClinGen gnomAD
CA1289324 rs773187432	184	Y>C		No	ClinGen ExAC gnomAD
rs894875184 CA33387093	187	I>M		No	ClinGen TOPMed gnomAD
CA1289321 rs774862497	187	I>T		No	ClinGen ExAC gnomAD
CA1289322 rs748606267	187	I>V		No	ClinGen ExAC gnomAD
rs769063354 CA343872733	188	I>F		No	ClinGen ExAC gnomAD
CA1289320 rs769063354	188	I>V		No	ClinGen ExAC gnomAD
CA1289319 rs749646628	195	R>G		No	ClinGen ExAC TOPMed gnomAD
rs755738256 CA1289317	203	V>I		No	ClinGen ExAC gnomAD
CA343872621 rs939000328 COSM900909	205	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA33387079 rs939000328	205	R>G		No	ClinGen TOPMed
CA1289315 rs145284891	205	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA1289316 rs145284891	205	R>L		No	ClinGen ESP ExAC gnomAD
CA33387073 rs867310609	206	H>R		No	ClinGen Ensembl
rs1163710236 CA343872516	211	E>D		No	ClinGen Ensembl
CA33387070 rs918272728	211	E>G		No	ClinGen TOPMed
CA1289314 rs756722870	211	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	213	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751468468 CA1289313	213	K>R		No	ClinGen ExAC gnomAD
rs868435088 CA33387064	214	S>F		No	ClinGen Ensembl
CA1289312 rs764115207	215	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA33387060 rs995312610	217	I>T		No	ClinGen TOPMed gnomAD
CA343872395 rs1473667436	218	A>T		No	ClinGen TOPMed
CA343872178 rs1557990887	220	S>F		No	ClinGen Ensembl
CA343872160 rs1461385483	221	T>A		No	ClinGen gnomAD
rs114355007 CA1289293	222	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1214654475 CA343872122	223	K>E		No	ClinGen TOPMed
CA343872082 rs1274983753	224	P>T		No	ClinGen TOPMed
CA343871997 rs1484665278	227	E>G		No	ClinGen TOPMed
TCGA novel	228	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777898690 CA1289292	228	I>T		No	ClinGen ExAC TOPMed gnomAD
CA1289290 rs752642001	233	D>G		No	ClinGen ExAC gnomAD
CA1289291 rs200802961	233	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM225451 rs778856321 CA1289289	234	T>M	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs577145249 CA33386775	235	D>N		No	ClinGen Ensembl
rs1571354003 CA343871726	237	Q>R		No	ClinGen Ensembl
CA343871671 rs1557990845	239	C>S		No	ClinGen Ensembl
rs535319004 CA1289286	240	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1371567941 CA343871603	241	N>S		No	ClinGen TOPMed
CA343871569 rs1571353977	242	Y>C		No	ClinGen Ensembl
CA1289285 rs761836309	243	S>C		No	ClinGen ExAC gnomAD
rs1031912156 CA33386772	243	S>P		No	ClinGen Ensembl
CA343871501 rs1316192751	244	I>M		No	ClinGen gnomAD
CA1289284 rs751612882	245	P>S		No	ClinGen ExAC TOPMed gnomAD
CA1289283 rs376174771	246	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs763485397 CA1289282	249	D>E		No	ClinGen ExAC gnomAD
CA1289281 rs373060680	250	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA343871339 rs1433367391	250	S>Y		No	ClinGen TOPMed
CA343871325 COSM69920 rs1441063287	251	Y>H	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs891380186 CA33386763	252	F>C		No	ClinGen TOPMed
rs770069989 CA1289280	252	F>V		No	ClinGen ExAC gnomAD
rs1328594302 CA343871275	253	N>Y		No	ClinGen gnomAD
CA1289279 rs759934706	254	P>S		No	ClinGen ExAC gnomAD
TCGA novel	256	M>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745849394 CA33386756	260	R>P		No	ClinGen gnomAD
rs745849394 CA343871103	260	R>Q		No	ClinGen gnomAD
CA1289277 rs371545842	260	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA343870988 rs1373200877	261	Q>H		No	ClinGen TOPMed
rs1396983278 CA343870986	262	L>I		No	ClinGen gnomAD
CA1289262 rs759860174	263	I>T		No	ClinGen ExAC gnomAD
rs1431520337 CA343870916	266	T>A		No	ClinGen TOPMed
CA1289261 rs777032620	268	A>P		No	ClinGen ExAC
CA1289259 rs369669193	269	A>G		No	ClinGen ESP ExAC gnomAD
CA1289260 rs369669193	269	A>V		No	ClinGen ESP ExAC gnomAD
CA1289258 rs772941736	271	A>S		No	ClinGen ExAC
CA1289257 rs771763449	272	E>G		No	ClinGen ExAC gnomAD
TCGA novel	272	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1571353523 CA343870771	273	E>G		No	ClinGen Ensembl
CA1289256 rs747654577	274	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1571353504 CA343870700	275	K>N		No	ClinGen Ensembl
TCGA novel	275	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA33386629 rs757326905	279	C>R		No	ClinGen Ensembl
rs1271896658 CA343870423	283	F>L		No	ClinGen gnomAD
CA1289254 rs768613869	285	A>T		No	ClinGen ExAC gnomAD
rs1326483262 CA343870404	285	A>V		No	ClinGen gnomAD
CA1289236 rs562672448	288	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1289235 rs368130438	289	M>T		No	ClinGen ESP ExAC gnomAD
rs778886537 CA33386045	289	M>V		No	ClinGen Ensembl
CA1289234 rs72741812	296	H>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1433379910 CA343869273	296	H>Y		No	ClinGen TOPMed
CA1289233 rs775237107	297	L>F		No	ClinGen ExAC gnomAD
CA343869243 rs1229242865	299	N>K		No	ClinGen TOPMed
CA343869246 rs1307689602	299	N>S		No	ClinGen TOPMed
CA343869236 rs1253730643	301	V>I		No	ClinGen TOPMed
rs778011357 CA1289230	304	T>I		No	ClinGen ExAC gnomAD
CA1289229 rs143021633	305	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs143629808 CA1289228	306	N>S		No	ClinGen ESP ExAC gnomAD
rs143629808 CA33386031	306	N>T		No	ClinGen ESP ExAC gnomAD
rs1437981524 CA343869188	308	L>S		No	ClinGen gnomAD
rs1032164560 CA33386027	313	V>L		No	ClinGen TOPMed
rs1262247904 CA343869144	314	T>I		No	ClinGen TOPMed
rs1001130624 CA33386024	315	L>P		No	ClinGen TOPMed
rs766988222 CA1289224	324	K>N		No	ClinGen ExAC TOPMed gnomAD
rs750791776 CA1289222	327	V>G		No	ClinGen ExAC TOPMed gnomAD
rs756585761 CA1289223	327	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1408914007 CA343869031	331	S>G		No	ClinGen TOPMed
rs761587178 CA1289220	331	S>R		No	ClinGen ExAC TOPMed gnomAD
CA1289219 rs773805422	333	E>D		No	ClinGen ExAC gnomAD
CA343868979 rs1288653831	337	S>R		No	ClinGen TOPMed
CA1289218 rs79124087	338	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA33386008 rs1045430274	340	I>T		No	ClinGen TOPMed
CA343868905 rs1281007649	343	E>G		No	ClinGen TOPMed
CA343868915 rs1326563972	343	E>K		No	ClinGen gnomAD
CA343868890 rs1557989247	344	G>E		No	ClinGen Ensembl
rs775568327 CA1289215	345	E>Q		No	ClinGen ExAC gnomAD
COSM159542 rs769691761 CA1289214	346	K>N	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA1289213 rs557667926	349	G>C		No	ClinGen 1000Genomes ExAC gnomAD
rs557667926 CA343868798	349	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs546085666 CA1289212	350	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770674466 CA1289211	350	N>S		No	ClinGen ExAC TOPMed gnomAD
rs770674466 CA343868767	350	N>T		No	ClinGen ExAC TOPMed gnomAD
rs1214873274 CA343868679	353	V>L		No	ClinGen gnomAD
rs1214873274 CA343868685	353	V>M		No	ClinGen gnomAD
CA1289209 rs778988404	354	T>N		No	ClinGen ExAC TOPMed gnomAD
rs768845187 CA1289208	355	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1282626459 CA343868413	360	V>A		No	ClinGen TOPMed gnomAD
rs370110033 CA1289207	363	H>N		No	ClinGen ESP ExAC gnomAD
CA343868302 rs1267064049	364	L>F		No	ClinGen TOPMed
CA1289206 rs780755204	365	R>S		No	ClinGen ExAC TOPMed gnomAD
CA343868222 rs1571351077	366	S>C		No	ClinGen Ensembl
CA343868092 rs1200197232	370	I>T		No	ClinGen TOPMed
CA343867775 rs1431367362	371	H>R		No	ClinGen gnomAD
CA33385888 rs914000813	371	H>Y		No	ClinGen Ensembl
rs1328046505 CA343867502	378	S>P		No	ClinGen gnomAD
rs1310791506 CA343867466	379	V>L		No	ClinGen gnomAD
CA1289182 rs751843183	384	S>A		No	ClinGen ExAC TOPMed gnomAD
rs1175096492 CA343867209	385	A>S		No	ClinGen gnomAD
rs758010145 CA1289180	387	R>S		No	ClinGen ExAC gnomAD
rs987822180 CA33385875	389	I>R		No	ClinGen TOPMed
rs923049524 CA33385878	389	I>V		No	ClinGen TOPMed
rs1167914468 CA343867072	391	N>Y		No	ClinGen gnomAD
CA1289179 rs752306525	392	L>F		No	ClinGen ExAC gnomAD
rs758989886 CA1289177	394	I>M		No	ClinGen ExAC gnomAD
rs753837611 CA1289176	395	V>L		No	ClinGen ExAC gnomAD
CA343866840 rs1258533743	401	D>G		No	ClinGen gnomAD
CA1289175 rs367918583	402	I>T		No	ClinGen ESP ExAC gnomAD
rs771856900 CA1289172	413	A>V		No	ClinGen ExAC TOPMed gnomAD
rs986440156 CA1289169	414	R>Q		No	ClinGen Ensembl
rs1470952546 CA343866508	415	R>C		No	ClinGen TOPMed
rs775794292 CA1289168	415	R>H		No	ClinGen ExAC gnomAD
TCGA novel	417	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	418	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343866462 rs1439566929	418	G>R		No	ClinGen TOPMed gnomAD
CA1289164 rs375199980	423	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1289161 rs758725031	427	Y>N		No	ClinGen ExAC gnomAD
CA1289159 rs778531861	432	A>S		No	ClinGen ExAC gnomAD
CA343866230 rs1479740292	434	I>T		No	ClinGen gnomAD
CA33385807 rs969185393	435	V>I		No	ClinGen TOPMed
CA1289158 rs754521537	438	A>T		No	ClinGen ExAC gnomAD
CA33385804 rs1024081713	439	V>L		No	ClinGen TOPMed gnomAD
TCGA novel	441	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs190177287 CA1289140	443	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1289139 rs779430928	444	A>T		No	ClinGen ExAC TOPMed gnomAD
rs746929885 CA1289138	445	R>*		No	ClinGen ExAC gnomAD
rs1482815387 CA343893141	445	R>Q		No	ClinGen TOPMed
rs774291927 CA1289137	446	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs148611463 CA33450893	450	I>M		No	ClinGen ESP
rs767483087 CA1289136	450	I>V		No	ClinGen ExAC gnomAD
rs725847 CA33450887	451	E>Q		No	ClinGen Ensembl
rs1557988447 CA343892826	456	V>M		No	ClinGen Ensembl
CA343892770 rs1421682122	458	L>V		No	ClinGen gnomAD
CA1289132 rs377360983	466	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs144963644 CA1289131	467	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA1289130 rs766384504	472	P>A		No	ClinGen ExAC TOPMed gnomAD
CA1289129 rs760796359	472	P>L		No	ClinGen ExAC TOPMed gnomAD
CA343892371 rs766384504	472	P>S		No	ClinGen ExAC TOPMed gnomAD
CA343892396 rs766384504	472	P>T		No	ClinGen ExAC TOPMed gnomAD
CA1289128 rs773631363	473	T>A		No	ClinGen ExAC TOPMed gnomAD
CA343892297 rs1485452995	474	S>L		No	ClinGen gnomAD
rs1218342053 CA343892290	475	A>T		No	ClinGen gnomAD
rs1345218520 CA343892267	476	D>G		No	ClinGen gnomAD
rs1279036186 CA343892243	477	E>*		No	ClinGen gnomAD
rs762258694 CA1289126	478	T>A		No	ClinGen ExAC TOPMed gnomAD
CA343892191 rs1557988401	479	A>T		No	ClinGen Ensembl
rs774729165 CA1289125	480	K>R		No	ClinGen ExAC gnomAD
TCGA novel	480	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1381020736 CA343892129	481	K>E		No	ClinGen gnomAD
CA343892114 rs1342985006	481	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	482	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1299122261 CA343891875	486	I>N		No	ClinGen gnomAD
rs769252308 CA1289121	489	Q>R		No	ClinGen ExAC gnomAD
CA343891343 rs1281328059	499	D>E		No	ClinGen TOPMed
rs1379430696 CA343891298	501	N>S		No	ClinGen gnomAD
rs1311570147 CA343891264	502	M>T		No	ClinGen TOPMed
rs1015039806 CA33450806	503	V>L		No	ClinGen TOPMed gnomAD
CA343891184 rs1168317261	504	E>D		No	ClinGen gnomAD
CA343891173 rs1427779485	505	E>K		No	ClinGen gnomAD
CA343889508 rs1201074788	508	Y>H		No	ClinGen TOPMed gnomAD
rs376356749 CA33444260	509	R>G		No	ClinGen ESP TOPMed gnomAD
rs1278084077 CA343889416	512	P>L		No	ClinGen gnomAD
CA343889352 rs1201099038	514	N>K		No	ClinGen gnomAD
rs1360311756 CA343889263	518	S>G		No	ClinGen TOPMed
rs566590049 CA1289081	522	K>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1571344407 CA343889086	525	I>V		No	ClinGen Ensembl
CA343887850 rs1390561547	532	S>A		No	ClinGen TOPMed
rs766099997 CA1289060	535	L>F		No	ClinGen ExAC gnomAD
TCGA novel	536	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343887742 rs1484096589	537	N>H		No	ClinGen Ensembl
CA33441440 rs772419633	537	N>S		No	ClinGen TOPMed
CA343887688 rs1347213890	539	G>*		No	ClinGen gnomAD
rs1015591613 CA33441397	546	F>L		No	ClinGen Ensembl
rs1438516870 CA343887465	548	S>F		No	ClinGen gnomAD
TCGA novel	548	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1013631737 CA33441395	551	H>R		No	ClinGen TOPMed gnomAD
CA343887306 rs1317299108	554	D>H		No	ClinGen gnomAD
CA33441393 rs199733622	556	I>L		No	ClinGen 1000Genomes TOPMed
CA343887232 rs199733622	556	I>V		No	ClinGen 1000Genomes TOPMed
rs771416721 CA1289058	557	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA33441370 rs896461743	558	T>I		No	ClinGen Ensembl
rs1362017260 CA343887118	559	L>P		No	ClinGen gnomAD
CA343887096 rs1433546583	560	I>T		No	ClinGen TOPMed
CA343887059 rs1320233017	562	T>S		No	ClinGen TOPMed
rs748129246 CA1289056	565	F>C		No	ClinGen ExAC gnomAD
rs1173682438 CA343886888	568	E>D		No	ClinGen gnomAD
CA1289053 rs768558944	570	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1193345797 CA343886791	572	Q>H		No	ClinGen gnomAD
CA1289051 rs372163711	576	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs757495654 CA1289050	577	I>V		No	ClinGen ExAC gnomAD
rs1208982042 CA343886651	579	A>P		No	ClinGen TOPMed gnomAD
CA343886641 rs1208982042	579	A>T		No	ClinGen TOPMed gnomAD
CA343886610 rs1257255833	580	S>Y		No	ClinGen TOPMed
CA1289048 rs374771924	582	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA343886496 rs1380684870	583	V>A		No	ClinGen gnomAD
CA1289047 rs142906342	584	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1289046 rs200485806	585	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA33440429 rs374273780	588	E>A		No	ClinGen ESP TOPMed gnomAD
rs1050147154 CA33440400	589	N>S		No	ClinGen Ensembl
rs1163164472 CA343885594	591	V>I		No	ClinGen TOPMed gnomAD
CA343885578 rs941645198	592	F>I		No	ClinGen TOPMed gnomAD
CA343885572 rs941645198	592	F>L		No	ClinGen TOPMed gnomAD
CA33440396 rs941645198	592	F>V		No	ClinGen TOPMed gnomAD
CA33440379 rs995007513	593	I>T		No	ClinGen gnomAD
CA1289027 rs148293273	593	I>V		No	ClinGen ESP ExAC gnomAD
CA343885413 rs1179197380	595	T>S		No	ClinGen gnomAD
CA343885401 rs1432423220	596	T>A		No	ClinGen TOPMed
rs1459000239 CA343885384	596	T>R		No	ClinGen TOPMed gnomAD
CA33440366 rs541908863	597	D>G		No	ClinGen 1000Genomes TOPMed gnomAD
CA343885364 rs541908863	597	D>V		No	ClinGen 1000Genomes TOPMed gnomAD
rs770328321 CA1289026	599	T>N		No	ClinGen ExAC
CA343885310 rs1322080089	600	T>A		No	ClinGen gnomAD
rs1221713704 CA343885274	602	D>V		No	ClinGen gnomAD
CA1289025 rs748146555	603	N>D		No	ClinGen ExAC gnomAD
rs1571341796 CA343885222	604	Y>D		No	ClinGen Ensembl
rs1309284266 CA343885179	606	A>V		No	ClinGen gnomAD
CA343885164 rs1253757017	607	Q>R		No	ClinGen TOPMed
CA343885155 rs1448195031	608	G>R		No	ClinGen gnomAD
CA1289002 rs749864131	611	K>R		No	ClinGen ExAC gnomAD
CA1289000 rs756585849	612	S>G		No	ClinGen ExAC gnomAD
CA343883611 rs1257261643	612	S>N		No	ClinGen TOPMed
CA1289001 rs756585849	612	S>R		No	ClinGen ExAC gnomAD
CA33437345 rs998983245	613	N>I		No	ClinGen Ensembl
rs781569516 CA1288998	613	N>K		No	ClinGen ExAC TOPMed gnomAD
CA343883466 rs1263512818	617	T>I		No	ClinGen gnomAD
CA1288997 rs756888660	618	N>T		No	ClinGen ExAC gnomAD
CA1288996 rs199729807	619	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA343883325 rs1571339977	622	K>R		No	ClinGen Ensembl
rs752698833 CA1288993	626	D>A		No	ClinGen ExAC TOPMed gnomAD
rs752698833 CA343883227	626	D>V		No	ClinGen ExAC TOPMed gnomAD
rs867387034 CA33437210	628	S>I		No	ClinGen Ensembl
rs765131830 CA1288992	629	T>S		No	ClinGen ExAC gnomAD
CA343883101 rs776315469	630	E>D		No	ClinGen ExAC TOPMed gnomAD
CA1288991 rs759378445	630	E>G		No	ClinGen ExAC gnomAD
rs1186933884 CA343883030	633	P>A		No	ClinGen TOPMed
rs796581583 CA33437197	636	Y>*		No	ClinGen Ensembl
TCGA novel	637	N>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343882877 rs1402009616	637	N>S		No	ClinGen gnomAD
CA343882802 rs1400172826	640	R>G		No	ClinGen gnomAD
CA1288987 rs774615406	643	I>V		No	ClinGen ExAC gnomAD
CA343882589 rs1360866088	646	M>I		No	ClinGen gnomAD
rs1367586946 CA343882255	653	K>R		No	ClinGen gnomAD
rs1247726125 CA343882113	656	C>F		No	ClinGen TOPMed gnomAD
rs1247726125 CA343882117	656	C>Y		No	ClinGen TOPMed gnomAD
rs370765259 CA1288972	657	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA343882067 rs370765259	657	Y>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	659	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343881967 rs1279500339	661	A>V		No	ClinGen TOPMed
CA33437007 rs866952288	662	G>D		No	ClinGen Ensembl
rs1457671073 CA343881878	664	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA343881861 rs1259143514	664	R>P		No	ClinGen gnomAD
rs1259143514 CA343881866	664	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA33436998 rs909764873	665	V>I		No	ClinGen Ensembl
rs760511079 CA1288970	667	R>*		No	ClinGen ExAC gnomAD
CA1288969 rs774750993	673	M>V		No	ClinGen ExAC gnomAD
CA33436979 rs1046962945	675	V>I		No	ClinGen gnomAD
COSM208895 rs764389177 CA1288968	676	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs929846222 CA33436975	677	T>A		No	ClinGen Ensembl
TCGA novel	681	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA343881135 rs763217069	686	S>C		No	ClinGen ExAC gnomAD
CA1288967 rs763217069	686	S>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1288965 rs769926700	687	I>M		No	ClinGen ExAC TOPMed gnomAD
CA1288966 rs775742776	687	I>V		No	ClinGen ExAC gnomAD
TCGA novel	689	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	691	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777183997 CA1288963	693	T>I		No	ClinGen ExAC gnomAD
CA1288962 rs764498865	696	Y>C		No	ClinGen ExAC
rs1341101347 CA343880735	697	T>A		No	ClinGen gnomAD
CA343880561 rs1450312120	701	S>A		No	ClinGen TOPMed gnomAD
CA343880564 rs1450312120	701	S>P		No	ClinGen TOPMed gnomAD
CA343880516 rs1267029879	703	S>G		No	ClinGen gnomAD
rs1557982865 CA343880444	704	H>Y		No	ClinGen Ensembl
CA343880295 rs1172622150	707	S>*		No	ClinGen TOPMed
CA1288955 rs771737496	711	D>E		No	ClinGen ExAC TOPMed gnomAD
rs777455821 CA1288956	711	D>N		No	ClinGen ExAC gnomAD
rs1417343597 CA343880174	712	T>A		No	ClinGen TOPMed
rs746828583 CA33436842	714	T>N		No	ClinGen TOPMed gnomAD
CA343880117 rs746828583	714	T>S		No	ClinGen TOPMed gnomAD
rs747762957 CA1288954	715	E>Q		No	ClinGen ExAC gnomAD
CA1288951 rs143307217	717	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1288952 rs778401376	717	V>I		No	ClinGen ExAC gnomAD
CA343880019 rs1329554835	719	M>V		No	ClinGen TOPMed
rs753782512 CA1288950	723	D>N		No	ClinGen ExAC TOPMed
CA343879877 rs1388181268	724	K>N		No	ClinGen gnomAD
CA1288949 rs780005499	724	K>R		No	ClinGen ExAC gnomAD
CA343879871 rs1358274450	725	A>T		No	ClinGen gnomAD
rs755911496 CA1288948	726	E>*		No	ClinGen ExAC gnomAD
rs755911496 CA343879857	726	E>K		No	ClinGen ExAC gnomAD
CA1288947 rs750264594	727	A>S		No	ClinGen ExAC gnomAD
rs1381621721 CA343879830	727	A>V		No	ClinGen gnomAD
rs368015762 CA1288946	728	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1288945 rs763270119	729	G>C		No	ClinGen ExAC gnomAD
CA343879804 rs752911882	729	G>D		No	ClinGen ExAC gnomAD
rs752911882 CA1288944	729	G>V		No	ClinGen ExAC gnomAD
rs1168565673 CA343879798	730	C>R		No	ClinGen gnomAD
rs1463274194 CA343879741	733	W>C		No	ClinGen TOPMed gnomAD
CA343879738 rs1571339612	734	W>E		No	ClinGen Ensembl

No associated diseases with Q7Z2T5

2 regional properties for Q7Z2T5

Type	Name	Position	InterPro Accession
domain	Importin-beta, N-terminal domain	22 - 102	IPR001494
domain	Exportin-2, central domain	195 - 441	IPR013713

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.
RNA binding	Binding to an RNA molecule or a portion thereof.
tRNA (guanine-N2-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.
tRNA binding	Binding to a transfer RNA.

2 GO annotations of biological process

Name	Definition
behavior	The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
tRNA N2-guanine methylation	The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NXH9	TRMT1	tRNA (guanine(26)-N(2))-dimethyltransferase	Homo sapiens (Human)	PR
Q3TX08	Trmt1	tRNA (guanine(26)-N(2))-dimethyltransferase	Mus musculus (Mouse)	PR
Q9LFU5	At5g15810	Probable tRNA (guanine(26)-N(2))-dimethyltransferase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SRU7	At3g02320	Probable tRNA (guanine(26)-N(2))-dimethyltransferase 2	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MENMAEEELL	PLEKEEVEVA	QVQVPTPARD	SAGVPAPAPD	SALDSAPTPA	SAPAPAPALA
70	80	90	100	110	120
QAPALSPSLA	SAPEEAKSKR	HISIQRQLAD	LENLAFVTDG	NFDSASSLNS	DNLDAGNRQA
130	140	150	160	170	180
CPLCPKEKFR	ACNSHKLRRH	LQNLHWKVSV	EFEGYRMCIC	HLPCRPVKPN	IIGEQITSKM
190	200	210	220	230	240
GAHYHCIICS	ATITRRTDML	GHVRRHMNKG	ETKSSYIAAS	TAKPPKEILK	EADTDVQVCP
250	260	270	280	290	300
NYSIPQKTDS	YFNPKMKLNR	QLIFCTLAAL	AEERKPLECL	DAFGATGIMG	LQWAKHLGNA
310	320	330	340	350	360
VKVTINDLNE	NSVTLIQENC	HLNKLKVVVD	SKEKEKSDDI	LEEGEKNLGN	IKVTKMDANV
370	380	390	400	410	420
LMHLRSFDFI	HLDPFGTSVN	YLDSAFRNIR	NLGIVSVTST	DISSLYAKAQ	HVARRHYGCN
430	440	450	460	470	480
IVRTEYYKEL	AARIVVAAVA	RAAARCNKGI	EVLFAVALEH	FVLVVVRVLR	GPTSADETAK
490	500	510	520	530	540
KIQYLIHCQW	CEERIFQKDG	NMVEENPYRQ	LPCNCHGSMP	GKTAIELGPL	WSSSLFNTGF
550	560	570	580	590	600
LKRMLFESLH	HGLDDIQTLI	KTLIFESECT	PQSQFSIHAS	SNVNKQEENG	VFIKTTDDTT
610	620	630	640	650	660
TDNYIAQGKR	KSNEMITNLG	KKQKTDVSTE	HPPFYYNIHR	HSIKGMNMPK	LKKFLCYLSQ
670	680	690	700	710	720
AGFRVSRTHF	DPMGVRTDAP	LMQFKSILLK	YSTPTYTGGQ	SESHVQSASE	DTVTERVEMS
730
VNDKAEASGC	RRW