AiPD: Autoinhibited Protein Database

Gene name	At5g15810 (F14F8_190)
Protein name	Probable tRNA (guanine(26)-N(2))-dimethyltransferase 1
Names	tRNA 2,2-dimethylguanosine-26 methyltransferase 1, tRNA(guanine-26,N(2)-N(2)) methyltransferase 1, tRNA(m(2,2)G26)dimethyltransferase 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G15810
EC number	2.1.1.216: Methyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

509-593 (Predicted disordered autoinhibitory region) PR

509-593 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9LFU5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_5_5158510_C_A	43	L>I	No	1000Genomes
tmp_5_5158591_G_A	70	E>K	No	1000Genomes
ENSVATH06973440	72	D>N	No	1000Genomes
tmp_5_5158616_A_T	78	K>M	No	1000Genomes
ENSVATH00624111	84	E>V	No	1000Genomes
tmp_5_5158640_G_A	86	G>D	No	1000Genomes
ENSVATH00624112	91	K>N	No	1000Genomes
tmp_5_5158684_C_G	101	Q>E	No	1000Genomes
ENSVATH06973442	101	Q>L	No	1000Genomes
tmp_5_5159092_G_A	163	R>K	No	1000Genomes
ENSVATH14043232	209	L>F	No	1000Genomes
ENSVATH14043233	218	D>G	No	1000Genomes
ENSVATH00624116	316	I>M	No	1000Genomes
ENSVATH10771907	349	D>E	No	1000Genomes
ENSVATH03060698	363	I>V	No	1000Genomes
tmp_5_5160213_A_T	384	M>L	No	1000Genomes
tmp_5_5160457_C_G	436	I>M	No	1000Genomes
tmp_5_5160470_C_T	441	R>C	No	1000Genomes
ENSVATH14043335	449	P>S	No	1000Genomes
tmp_5_5160672_T_A	478	S>T	No	1000Genomes
ENSVATH00624118	504	L>F	No	1000Genomes
tmp_5_5160927_G_C	530	G>R	No	1000Genomes
ENSVATH03060700	552	N>D	No	1000Genomes
ENSVATH03060701	552	N>S	No	1000Genomes
ENSVATH00624119	589	F>I	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)	183 - 480	IPR002314
domain	Anticodon-binding	505 - 595	IPR004154
domain	Aminoacyl-tRNA synthetase, class II	10 - 372	IPR006195
domain	Glycyl-tRNA synthetase-like core domain	12 - 360	IPR033731

		Description
EC Number	2.1.1.216	Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
tRNA (guanine-N2-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.
tRNA binding	Binding to a transfer RNA.

Name	Definition
tRNA N2-guanine methylation	The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q7Z2T5	TRMT1L	TRMT1-like protein	Homo sapiens (Human)	PR
Q9NXH9	TRMT1	tRNA (guanine(26)-N(2))-dimethyltransferase	Homo sapiens (Human)	PR
Q3TX08	Trmt1	tRNA (guanine(26)-N(2))-dimethyltransferase	Mus musculus (Mouse)	PR
Q9SRU7	At3g02320	Probable tRNA (guanine(26)-N(2))-dimethyltransferase 2	Arabidopsis thaliana (Mouse-ear cress)	PR